Results 271 to 280 of about 193,025 (292)

Organ-, body- and disease-on-a-chip systems

Lab on a Chip, 2017
Thought leader Michael Shuler introduces the Lab on a Chip organ, body and disease on a chip thematic collection.
M. Shuler
openaire   +3 more sources

Advances in organ-, body-, and disease-on-a-chip systems

Lab on a Chip, 2019
Thought leader Michael Shuler provides an update on the Lab on a Chip organ-, body- and disease- on-a-chip thematic collection.
M. Shuler
openaire   +3 more sources

Modeling Heart Diseases on a Chip: Advantages and Future Opportunities

Circulation Research, 2023
Heart disease is a significant burden on global health care systems and is a leading cause of death each year. To improve our understanding of heart disease, high quality disease models are needed. These will facilitate the discovery and development of new treatments for heart disease.
Omar Mourad, Ryan Yee, Mengyuan Li, Sara S. Nunes   +3 more
openaire   +3 more sources

Abstract Mo089: Fontan-Associated Liver Disease On A Chip

Circulation Research
Introduction: The Fontan procedure is performed in children with single ventricle physiology, and has led to excellent short-term palliation and survival rates but at the cost of long-term complications. Fontan-associated liver disease (FALD) results from hemodynamic changes following the Fontan procedure, leading to ...
Sarah Rezapourdamanab, Yamini Singh, Sophia Norton, Boeun Hwang, Linqi Jin, Mehdi Salar Amoli, Shweta Karnik, Reza Avazmohammadi, Sunder Neelakantan, Lakshmi Dasi, Rene Romero, Holly Bauser Heaton, Vahid Serpooshan   +12 more
openaire   +2 more sources

Degenerative disease‐on‐a‐chip: Developing microfluidic models for rapid availability of newer therapies

Biotechnology Journal, 2021
AbstractBackgroundUnderstanding the pathophysiology of degenerative diseases pertaining to nervous system, ocular region, bone/cartilage, and muscle are still being comprehended, thus delaying the availability of targeted therapies.Purpose and ScopeNewer micro‐physiological systems (organ‐on‐chip technology) involves development of more sophisticated ...
Devashree Jahagirdar, Prachi Bangde, Ratnesh Jain, Prajakta Dandekar   +3 more
openaire   +2 more sources

Opportunities and considerations for studying liver disease with microphysiological systems on a chip.

Lab on a Chip, 2023
Advances in microsystem engineering have enabled the development of highly controlled models of the liver that better recapitulate the unique in vivo biological conditions. In just a few short years, substantial progress has been made in creating complex
Adiya Otumala, Dominick J. Hellen, C. A. Luna, P. Delgado, A. Dissanayaka, Chidozie Ugwumadu, O. Oshinowo, Md. Mydul Islam, Luyao Shen, S. Karpen, D. Myers   +10 more
semanticscholar   +1 more source

Blood-brain barrier (BBB)-on-a-chip: a promising breakthrough in brain disease research.

Lab on a Chip, 2022
The blood-brain barrier (BBB) represents a key challenge in developing brain-penetrating therapeutic molecules. BBB dysfunction is also associated with the onset and progression of various brain diseases.
Bo Peng, Shiping Hao, Ziqiu Tong, Hua Bai, Sijun Pan, Kahleong Lim, Lin Li, N. Voelcker, Wei Huang   +8 more
semanticscholar   +1 more source

A hiPSC-derived lineage-specific vascular smooth muscle cell-on-a-chip identifies aortic heterogeneity across segments.

Lab on a Chip, 2023
Aortic aneurysm (AA), a potentially lethal condition with the characteristic of aortic dilatation, can only be treated by surgical or endovascular procedures.
Gang Liu, Jun Li, Yang Ming, Bitao Xiang, Yibing Chen, Nan Chen, Mieradilijiang Abudupataer, Shichao Zhu, X. Zhou, Xiaoning Sun, Yongxin Sun, H. Lai, Sisi Feng, Chunsheng Wang, K. Zhu   +14 more
semanticscholar   +1 more source

The contribution of initial concussive forces and resulting acrolein surge to β-amyloid accumulation and functional alterations in neuronal networks using a TBI-on-a-chip model.

Lab on a Chip, 2023
Trauma-induced Alzheimer's disease (AD) is rapidly emerging as a major consequence of traumatic brain injuries (TBI), with devastating social and economic impacts.
Edmond A. Rogers, Timothy B. Beauclair, Jhon Martinez, Shatha J Mufti, David Kim, Siyuan Sun, Rachel L Stingel, A. Dieterly, Nikita Krishnan, Jennifer S Crodian, Riyi Shi   +10 more
semanticscholar   +1 more source

Modeling mechanisms underlying differential inflammatory responses to COVID-19 in type 2 diabetes using a patient-derived microphysiological organ-on-a-chip system.

Lab on a Chip, 2023
Background: COVID-19 pandemic has caused more than 6 million deaths worldwide. Co-morbid conditions such as Type 2 Diabetes (T2D) have increased mortality in COVID-19.
V. Negi, Dillon Gavlock, Mark T. Miedel, Jeong Kyung Lee, T. Shun, A. Gough, L. Vernetti, Andrew M. Stern, D. L. Taylor, Vijay K Yechoor   +9 more
semanticscholar   +1 more source