Results 251 to 260 of about 92,114,249 (286)

Modeling Heart Diseases on a Chip: Advantages and Future Opportunities

Circulation Research, 2023
Heart disease is a significant burden on global health care systems and is a leading cause of death each year. To improve our understanding of heart disease, high quality disease models are needed. These will facilitate the discovery and development of new treatments for heart disease.
Omar Mourad, Ryan Yee, Mengyuan Li, Sara S. Nunes   +3 more
openaire   +2 more sources

Degenerative disease‐on‐a‐chip: Developing microfluidic models for rapid availability of newer therapies

Biotechnology Journal, 2021
AbstractBackgroundUnderstanding the pathophysiology of degenerative diseases pertaining to nervous system, ocular region, bone/cartilage, and muscle are still being comprehended, thus delaying the availability of targeted therapies.Purpose and ScopeNewer micro‐physiological systems (organ‐on‐chip technology) involves development of more sophisticated ...
Devashree Jahagirdar, Prachi Bangde, Ratnesh Jain, Prajakta Dandekar   +3 more
openaire   +2 more sources

Shear and endothelial induced late-stage calcific aortic valve disease-on-a-chip develops calcium phosphate mineralizations

Lab on a Chip, 2022
We fabricated PDMS microfluidics with an internal collagen hydrogel to develop a bench-top model of calcific aortic valve disease.
Melissa Mendoza, Mei-Hsiu Chen, Peter Huang, Gretchen J. Mahler   +3 more
openaire   +2 more sources

A Sexually Transmitted Disease (STD) DNA chip for the diagnosis of genitourinary infections

Biosensors and Bioelectronics, 2011
The results of an investigation aimed at the development of a DNA chip for the detection of genitourinary infections are described. Through analysis of over 35,000 clinical cases, 14 pathogens which are most abundantly found among Koreans were selected and candidate sequences for capture probes were accordingly chosen by considering their sequences and
Chung, WY Chung, Won-young, Jung, YL Jung, Ye-Lim, Park, KS Park, Ki-Soo, Jung, CH Jung, Cheul-Hee, Shin, SC Shin, Sung-Chul, Hwang, SJ Hwang, Sang-Joon, Cho, DY Cho, Dae-Yeon, Cha, SH Cha, Sun-Ho, Lim, SK Lim, Si-Kyu, Park, HG Park, Hyun-Gyu   +9 more
openaire   +2 more sources

Solving Acne Inversa (Hidradenitis Suppurativa) in Crohn Disease with Buried Chip Skin Grafts

Journal of Cutaneous Medicine and Surgery, 2009
Background: Acne inversa is a progressive chronic inflammatory disease associated with abscess and fistula formation and subsequent scarring. In recent years, an increasing number of reports have been published about acne inversa and concomitantly occurring Crohn disease.
Oliver, Bleiziffer, Adrian, Dragu, Ulrich, Kneser, Raymund E, Horch   +3 more
openaire   +2 more sources

Custom‐Built CDNA Arrays for the Study of Neuronal Differentiation and Disease: The Smart Chip

ChemInform, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Lilian W. Chiang, Dave Ficenec, Jill M. Grenier   +2 more
openaire   +1 more source

Organ-, body- and disease-on-a-chip systems

Lab on a Chip, 2017
Thought leader Michael Shuler introduces the Lab on a Chip organ, body and disease on a chip thematic collection.
openaire   +2 more sources

Advances in organ-, body-, and disease-on-a-chip systems

Lab on a Chip, 2019
Thought leader Michael Shuler provides an update on the Lab on a Chip organ-, body- and disease- on-a-chip thematic collection.
openaire   +2 more sources

A Comprehensive Lifestyle Intervention to Prevent Type 2 Diabetes and Cardiovascular Diseases: the German CHIP Trial

Prevention Science, 2016
The prevalence of type 2 diabetes is continuously increasing. This chronic metabolic disorder is difficult to treat and imposes a considerable economic burden on the healthcare system. In view of the fact that type 2 diabetes is primarily caused by behavioral factors, effective preventive strategies are urgently needed.
Wennehorst, K, Diehl, H, Mildenstein, K, Saliger, B, Tigges, C, Keil, T, Englert, Heike   +6 more
openaire   +3 more sources

Analysis of Differentially Activated Signaling Pathways in Myeloproliferative Disease Using Kinomics Chip Profiling

Blood, 2008
Abstract In a multitude of cases, oncogenic mutations are gain of function mutations that confer a constitutively activated gene product. Currently, evidence from a large body of experimental studies suggests that oncogenic transformation induced by activating kinase mutations is not sufficiently explained by constitutive kinase ...
Daniel B Lipka, Marie-Christine Blum, Florian H Heidel, Thomas Kindler, Thomas Fischer   +4 more
openaire   +1 more source