Results 231 to 240 of about 195,333 (281)

Routine inflammatory indices modify clonal hematopoiesis-related prognostic risk in patients undergoing percutaneous coronary intervention: a real-world cohort study. [PDF]

BMC Med
Shen X, Song Y, Zhao H, Xu J, Li J, Du M, Wang H, Chen S, Liu F, Yuan D, Liu R, Huang K, Li H, Cao J, Li T, Zeng G, Yan K, Li J, Liu M, Zhang K, Jiang P, Huang J, Yang Y, Gao R, Zhao X, Gu D, Lu X.   +26 more
europepmc   +1 more source

A Biomarker‐Driven Ovary–Endometrium Organ‐on‐a‐Chip Mimicking 3D Multicellular Complexity and Menstrual Cyclicity for Predicting Reproductive Toxicity

Advanced Science, EarlyView.
We present a dual‐organ, biomarker‐integrated ovaryendometrium organ‐on‐a‐chip that recapitulates 3D tissue complexity, menstrual cycle dynamics, and hormonal crosstalk. This platform enables real‐time, cell‐typespecific fluorescent readouts of reproductive toxicity using ANGPTL4 and SERPINB2 as early‐response reporters.
Soo‐Rim Kim, Eun‐kyung Min, Choon‐Mi Lee, Chan Hum Park, Byung‐Chul Oh, YunJae Jung, In‐Sun Hong   +6 more
wiley   +1 more source

Micro pharmacokinetics-pharmacodynamics monitoring of anti-Parkinson's disease drugs using a microphysiological BBB-brain organ-on-a-chip. [PDF]

Microsyst Nanoeng
Zhong Y, Huang M, Cao X, Lin RY, Zhang ZY, Zhu QQ, Lei Y, Liu AL.   +7 more
europepmc   +1 more source

LMO7 Suppresses Tumor‐Associated Macrophage Phagocytosis of Tumor Cells Through Degradation of LRP1

Advanced Science, EarlyView.
LMO7 in tumor‐associated macrophages suppresses phagocytosis of tumor cells and limits cytotoxic T lymphocytes infiltration, fostering tumor progression. Mechanistically, LMO7 mediates the ubiquitination and degradation of the phagocytic receptor LRP1, impairing its ability to engulf tumor cells and driving macrophages toward an antitumor phenotype ...
Mengkai Li, Tao Wang, Yuwen Zhong, Zhiming Wang, Wei Li, Zejian Wang, Xinyi Yang, Yu Qiao, Jianfeng Xiang, Wei Gu, Zishu Wang, Lei Sun, Feng Qian   +12 more
wiley   +1 more source

Rare Gain-of-Function Variants in IDH1 and IDH2 Confer Increased Risk of Immune-Mediated Rheumatic Diseases. [PDF]

ACR Open Rheumatol
Kaymakci MS, Hocaoğlu M, Warrington KJ, Sawalha AH.   +3 more
europepmc   +1 more source

ERK‐Mediated Phosphorylation of YAP Defines a Noncanonical FGF Signaling Mechanism in Stem Cells

Advanced Science, EarlyView.
With a powerful combination of in vivo, ex vivo, and in vitro models, the authors highlight a novel FGF‐ERK signaling regulation of YAP at the S128 site in neural crest‐derived stem cells. This study opens exciting new directions in stem cell biology and craniofacial biology, paving the way for potential innovations in the treatment of craniofacial ...
Xiaolei Zhao, Shannon Erhardt, Li Tang, Xiaotong Chen, Stephen M Farmer, Zixiu Cheng, Wen Chen, Ella Ziyuan Lu, Kihan Sung, Chang‐Ru Tsai, Mingjie Zheng, Sheng Zhang, Yang Liu, Jianxin Wang, Min Li, James F Martin, Jun Wang   +16 more
wiley   +1 more source

From microfluidics to nanodelivery: artificial intelligence reshapes neuropharmacology research strategies. [PDF]

Front Pharmacol
Chen C, Du X, Yang J, Zeng Y, Xie H, Wang D, Qi P, Zeng Y.   +7 more
europepmc   +1 more source

Liver-on-a-Chip: Searching for a Balance Between Biomimetics and Functionality. [PDF]

Biosensors (Basel)
Murashko A, Golubchikov D, Smirnova O, Oleynichenko K, Nesterova A, Vosough M, Svistunov A, Shpichka A, Timashev P.   +8 more
europepmc   +1 more source

Advances and applications of organ-on-a-chip technology. [PDF]

Cell Rep Methods
Kong JS, Kim J, Jang J, Cho DW.
europepmc   +1 more source

Microfluidic innovations in chronic kidney disease and renal fibrosis: from mechanistic insights to clinical applications. [PDF]

Front Med (Lausanne)
Liu A, Xiao K, Lin H.
europepmc   +1 more source