Results 241 to 250 of about 204,111 (283)

Blood-brain barrier (BBB)-on-a-chip: a promising breakthrough in brain disease research.

Lab on a Chip, 2022
The blood-brain barrier (BBB) represents a key challenge in developing brain-penetrating therapeutic molecules. BBB dysfunction is also associated with the onset and progression of various brain diseases.
Bo Peng, Shiping Hao, Ziqiu Tong, Hua Bai, Sijun Pan, Kahleong Lim, Lin Li, N. Voelcker, Wei Huang   +8 more
semanticscholar   +1 more source

Degenerative disease‐on‐a‐chip: Developing microfluidic models for rapid availability of newer therapies

Biotechnology Journal, 2021
AbstractBackgroundUnderstanding the pathophysiology of degenerative diseases pertaining to nervous system, ocular region, bone/cartilage, and muscle are still being comprehended, thus delaying the availability of targeted therapies.Purpose and ScopeNewer micro‐physiological systems (organ‐on‐chip technology) involves development of more sophisticated ...
Devashree Jahagirdar, Prachi Bangde, Ratnesh Jain, Prajakta Dandekar   +3 more
openaire   +2 more sources

A Sexually Transmitted Disease (STD) DNA chip for the diagnosis of genitourinary infections

Biosensors and Bioelectronics, 2011
The results of an investigation aimed at the development of a DNA chip for the detection of genitourinary infections are described. Through analysis of over 35,000 clinical cases, 14 pathogens which are most abundantly found among Koreans were selected and candidate sequences for capture probes were accordingly chosen by considering their sequences and
Chung, WY Chung, Won-young, Jung, YL Jung, Ye-Lim, Park, KS Park, Ki-Soo, Jung, CH Jung, Cheul-Hee, Shin, SC Shin, Sung-Chul, Hwang, SJ Hwang, Sang-Joon, Cho, DY Cho, Dae-Yeon, Cha, SH Cha, Sun-Ho, Lim, SK Lim, Si-Kyu, Park, HG Park, Hyun-Gyu   +9 more
openaire   +2 more sources

Solving Acne Inversa (Hidradenitis Suppurativa) in Crohn Disease with Buried Chip Skin Grafts

Journal of Cutaneous Medicine and Surgery, 2009
Background: Acne inversa is a progressive chronic inflammatory disease associated with abscess and fistula formation and subsequent scarring. In recent years, an increasing number of reports have been published about acne inversa and concomitantly occurring Crohn disease.
Oliver, Bleiziffer, Adrian, Dragu, Ulrich, Kneser, Raymund E, Horch   +3 more
openaire   +2 more sources

Custom‐Built CDNA Arrays for the Study of Neuronal Differentiation and Disease: The Smart Chip

ChemInform, 2003
AbstractFor Abstract see ChemInform Abstract in Full Text.
Lilian W. Chiang, Dave Ficenec, Jill M. Grenier   +2 more
openaire   +1 more source

A Comprehensive Lifestyle Intervention to Prevent Type 2 Diabetes and Cardiovascular Diseases: the German CHIP Trial

Prevention Science, 2016
The prevalence of type 2 diabetes is continuously increasing. This chronic metabolic disorder is difficult to treat and imposes a considerable economic burden on the healthcare system. In view of the fact that type 2 diabetes is primarily caused by behavioral factors, effective preventive strategies are urgently needed.
Wennehorst, K, Diehl, H, Mildenstein, K, Saliger, B, Tigges, C, Keil, T, Englert, Heike   +6 more
openaire   +3 more sources

Organ-on-a-Chip Models—New Possibilities in Experimental Science and Disease Modeling

Biomolecules
‘Organ-on-a-chip’ technology is a promising and rapidly evolving model in biological research. This innovative microfluidic cell culture device was created using a microchip with continuously perfused chambers, populated by living cells arranged to ...
Bartłomiej Wysoczański, Marcin Świątek, A. Wójcik-Gładysz   +2 more
semanticscholar   +1 more source

Human cardiac fibrosis-on-a-chip model recapitulates disease hallmarks and can serve as a platform for drug testing.

Biomaterials, 2019
While interstitial fibrosis plays a significant role in heart failure, our understanding of disease progression in humans is limited. To address this limitation, we have engineered a cardiac-fibrosis-on-a-chip model consisting of a microfabricated device
Olya Mastikhina, B.-U. Moon, Kenneth Williams, R. Hatkar, Dakota Gustafson, Omar Mourad, Xuetao Sun, Margaret Koo, A. Y. Lam, Yu Sun, Jason E. Fish, Edmond W K Young, Sara S. Nunes   +12 more
semanticscholar   +1 more source

Analysis of Differentially Activated Signaling Pathways in Myeloproliferative Disease Using Kinomics Chip Profiling

Blood, 2008
Abstract In a multitude of cases, oncogenic mutations are gain of function mutations that confer a constitutively activated gene product. Currently, evidence from a large body of experimental studies suggests that oncogenic transformation induced by activating kinase mutations is not sufficiently explained by constitutive kinase ...
Daniel B Lipka, Marie-Christine Blum, Florian H Heidel, Thomas Kindler, Thomas Fischer   +4 more
openaire   +1 more source

Cancer-on-a-chip for precision cancer medicine

Lab on a Chip
Many cancer therapies fail in clinical trials despite showing potent efficacy in preclinical studies. One of the key reasons is the adopted preclinical models cannot recapitulate the complex tumor microenvironment (TME) and reflect the heterogeneity and ...
Lunan Liu, Huishu Wang, Ruiqi Chen, Yujing Song, William I. Wei, David Baek, Mahan Gillin, K. Kurabayashi, Weiqiang Chen   +8 more
semanticscholar   +1 more source