Results 221 to 230 of about 1,230,509 (271)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Geometrically-engineered human motor assembloids-on-a-chip for neuromuscular interaction readout and hypoxia-driven disease modeling. [PDF]

Nat Commun
Zhang W, Yu L, Pan J, Deng J, Tong X, Zhao B, Liu W, Sun L, Zhang M, Han X, Liu T, Lu Y, Li J, Liu Y.   +13 more
europepmc   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source

Disease Modeling and External Model Evaluation Through Clinical Data Sharing Platform for HR+/HER2- Breast Cancer. [PDF]

CPT Pharmacometrics Syst Pharmacol
Yoshida K, Bruno R, Chanu P.
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Promoting mitochondrial dynamics by inhibiting the PINK1–PRKN pathway to relieve diabetic nephropathy

Disease Models & Mechanisms
Jun-yi Zhu, Joyce van de Leemput, Zhe Han   +2 more
doaj   +1 more source

Maturation of human cardiac organoids enables complex disease modeling and drug discovery. [PDF]

Nat Cardiovasc Res
Pocock MW, Reid JD, Robinson HR, Charitakis N, Krycer JR, Foster SR, Fitzsimmons RL, Lor M, Devilée LAC, Batho CAP, Tuano N, Howden SE, Vlahos K, Watt KI, Piers AT, Bibby K, McNamara JW, Sutton R, Iaprintsev V, Mathew J, Voges HK, Fortuna PRJ, Bass-Stringer S, Vivien C, Rae J, Parton RG, Firulli AB, Lisowski L, Huckstep H, Humphrey SJ, Lal S, Konstantinov IE, Weintraub RG, Elliott DA, Ramialison M, Porrello ER, Mills RJ, Hudson JE.   +37 more
europepmc   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Measuring artery diameter in rabbit angiograms for neurovascular disease modeling applications and device testing. [PDF]

Interv Neuroradiol
Khan Y, Franklin J, Cortese J, Bayraktar EA, Oliver AA, Ding YH, Lortscher S, Brinjikji W, Kadirvel R, Kallmes DF.   +9 more
europepmc   +1 more source

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source