Results 31 to 40 of about 1,230,509 (271)
Modeling infectious disease dynamics [PDF]
Science, 2020 The spread of the coronavirus SARS-CoV-2 has predictable ...
openaire +2 more sources
Applications of miRNAs in cardiac development, disease progression and regeneration
Stem Cell Research & Therapy, 2019 Development of the complex human heart is tightly regulated at multiple levels, maintaining multipotency and proliferative state in the embryonic cardiovascular progenitors and thereafter suppressing progenitor characteristics to allow for terminal ...
Jeremy Kah Sheng Pang +2 more
doaj +1 more source
Inference of RNA decay rate from transcriptional profiling highlights the regulatory programs of Alzheimer's disease. [PDF]
, 2017 The abundance of mRNA is mainly determined by the rates of RNA transcription and decay. Here, we present a method for unbiased estimation of differential mRNA decay rate from RNA-sequencing data by modeling the kinetics of mRNA metabolism.
Alkallas, Rached +3 more
core +3 more sources
Statistical Disease Progression Modeling in Alzheimer Disease [PDF]
Frontiers in Big Data, 2020 Background: The characterizing symptom of Alzheimer disease (AD) is cognitive deterioration. While much recent work has focused on defining AD as a biological construct, most patients are still diagnosed, staged, and treated based on their cognitive symptoms.
Lars Lau Raket, Lars Lau Raket
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Sickle Cell Disease Is an Inherent Risk for Asthma in a Sibling Comparison Study
Pediatric Blood &Cancer, EarlyView.ABSTRACT Introduction Sickle cell disease (SCD) and asthma share a complex relationship. Although estimates vary, asthma prevalence in children with SCD is believed to be comparable to or higher than the general population. Determining whether SCD confers an increased risk for asthma remains challenging due to overlapping symptoms and the ...
Suhei C. Zuleta De Bernardis +9 more
wiley +1 more source
A pair formation model with recovery: Application to mpox
Epidemics, 2023 The current global outbreaks of mpox is a unique infectious disease in the way it seems to be transmitting: it has been observed to be highly concentrated in communities of men who have sex with men (MSM) through pair formation, and also provides long ...
Matthew I. Betti +2 more
doaj +1 more source
Looking Back: Disease Modeling [PDF]
Cell Stem Cell, 2017 Over the past decade, the growth of stem cell-based models of human disorders has contributed to novel drug discovery and precision medicine possibilities. For our tenth anniversary, we asked authors who cited a selection of our most popular papers in this area about how these studies influenced them.
openaire +2 more sources
Psychosocial Outcomes in Patients With Endocrine Tumor Syndromes: A Systematic Review
Pediatric Blood &Cancer, EarlyView.ABSTRACT Introduction The combination of disease manifestations, the familial burden, and varying penetrance of endocrine tumor syndromes (ETSs) is unique. This review aimed to portray and summarize available data on psychosocial outcomes in patients with ETSs and explore gaps and opportunities for future research and care.
Daniël Zwerus +6 more
wiley +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background The Improving Population Outcomes for Renal Tumours of childhood (IMPORT) is a prospective clinical observational study capturing detailed demographic and outcome data on children and young people diagnosed with renal tumours in the United Kingdom and the Republic of Ireland.
Naomi Ssenyonga +56 more
wiley +1 more source
BMC Infectious Diseases, 2017 Background Individual-based models (IBMs) are useful to simulate events subject to stochasticity and/or heterogeneity, and have become well established to model the potential (re)emergence of pathogens (e.g., pandemic influenza, bioterrorism). Individual
Lander Willem +4 more
doaj +1 more source