Results 41 to 50 of about 1,236,451 (244)
Pediatric Blood &Cancer, EarlyView.ABSTRACT Although most malignant germ cell tumors (GCTs) are highly curable with cisplatin‐based therapy, options for patients with multiply relapsed/refractory disease remain limited. For this population, we report the first pediatric use of gemcitabine, docetaxel, melphalan, and carboplatin (GemDMC) as part of sequential cycles of high‐dose ...
Maria Frost +10 more
wiley +1 more source
Cell & Bioscience, 2021 Background SARS-CoV-2 causes COVID-19 which has a widely diverse disease profile. The mechanisms underlying its pathogenicity remain unclear. We set out to identify the SARS-CoV-2 pathogenic proteins that through host interactions cause the cellular ...
Jin-Gu Lee +5 more
doaj +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Osteonecrosis (ON) is a debilitating complication of acute lymphoblastic leukemia (ALL) therapy. While numerous studies have explored its incidence and associated risk factors, investigations using large‐scale cohorts remain important to characterize ON across heterogeneous populations.
Noémie de Villiers +5 more
wiley +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background Transfusion‐related iron overload (TRIO) is a late effect of therapy impacting survivors of childhood cancer and hematopoietic stem cell transplantation (HSCT) who receive frequent packed red blood cell (pRBC) transfusions. Surprisingly, there are no accepted guidelines to assist providers in identifying and treating at‐risk ...
Luke Gingell +3 more
wiley +1 more source
International Journal of Infectious Diseases, 2020 Background: Absolute numbers of COVID-19 cases and deaths reported to date in the sub-Saharan Africa (SSA) region have been significantly lower than those across the Americas, Asia and Europe.
Laura Skrip +13 more
doaj +1 more source
The role of caretakers in disease dynamics
, 2012 One of the key challenges in modeling the dynamics of contagion phenomena is to understand how the structure of social interactions shapes the time course of a disease. Complex network theory has provided significant advances in this context.
A.L. Barabási +29 more
core +1 more source
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background L‐asparaginase is a critical component in treatment protocols for pediatric acute lymphoblastic leukemia. Acute pancreatitis reactions can necessitate delays and, in some cases, discontinuation of L‐asparaginase, which compromises outcomes.
Edward J. Raack +39 more
wiley +1 more source
Progressive senescence programs induce intrinsic vulnerability to aging-related female breast cancer
Nature CommunicationsCancer incidence escalates exponentially with advancing age; however, the underlying mechanism remains unclear. In this study, we build a chronological molecular clock at single-cell transcription level with a mammary stem cell-enriched population to ...
Huiru Bai +8 more
doaj +1 more source
MYCN Amplification in RB1‐Inactivated Retinoblastoma: Association With High‐Risk Features
Pediatric Blood &Cancer, EarlyView.ABSTRACT Background MYCN amplification occurs in a subset of retinoblastoma cases, both with and without RB1 inactivation. It has been suggested that retinoblastomas with MYCN amplification represent a distinct entity with more aggressive clinical behavior.
Kyriaki Papaioannou +9 more
wiley +1 more source
Strong associations between microbe phenotypes and their network architecture
, 2009 Understanding the dependence and interplay between architecture and function in biological networks has great relevance to disease progression, biological fabrication and biological systems in general.
G. Schlosser +2 more
core +1 more source