Results 11 to 20 of about 659,696 (286)

Cancer disease: integrative modelling approaches [PDF]

, 2006
Cancer is a complex disease in which a variety of phenomena interact over a wide range of spatial and temporal scales. In this article a theoretical framework will be introduced that is capable of linking together such processes to produce a detailed ...
Alarcon, T, Byrne, HM, IEEE, Maini, PK, Owen, MR   +4 more
core   +1 more source

Health and economic burden of respiratory syncytial virus (RSV) disease and the cost-effectiveness of potential interventions against RSV among children under 5 years in 72 Gavi-eligible countries

BMC Medicine, 2020
Background Respiratory syncytial virus (RSV) frequently causes acute lower respiratory infection in children under 5, representing a high burden in Gavi-eligible countries (mostly low-income and lower-middle-income).
Xiao Li, Lander Willem, Marina Antillon, Joke Bilcke, Mark Jit, Philippe Beutels   +5 more
doaj   +1 more source

A Quantitative Systems Pharmacology Model of Gaucher Disease Type 1 Provides Mechanistic Insight Into the Response to Substrate Reduction Therapy With Eliglustat

CPT: Pharmacometrics & Systems Pharmacology, 2020
Gaucher’s disease type 1 (GD1) leads to significant morbidity and mortality through clinical manifestations, such as splenomegaly, hematological complications, and bone disease.
Ruth Abrams, Chanchala D. Kaddi, Mengdi Tao, Randolph J. Leiser, Giulia Simoni, Federico Reali, John Tolsma, Paul Jasper, Zachary vanRijn, Jing Li, Bradley Niesner, Jeffrey S. Barrett, Luca Marchetti, M. Judith Peterschmitt, Karim Azer, Susana Neves‐Zaph   +15 more
doaj   +1 more source

The impact of local and national restrictions in response to COVID-19 on social contacts in England: a longitudinal natural experiment

BMC Medicine, 2021
Background England’s COVID-19 response transitioned from a national lockdown to localised interventions. In response to rising cases, these were supplemented by national restrictions on contacts (the Rule of Six), then 10 pm closing for bars and ...
Christopher I. Jarvis, Amy Gimma, Kevin van Zandvoort, Kerry L. M. Wong, CMMID COVID-19 working group, W. John Edmunds   +5 more
doaj   +1 more source

Disease Mapping via Negative Binomial Regression M-quantiles [PDF]

, 2013
We introduce a semi-parametric approach to ecological regression for disease mapping, based on modelling the regression M-quantiles of a Negative Binomial variable. The proposed method is robust to outliers in the model covariates, including those due to
Chambers, Ray, Dreassi, Emanuela, Salvati, Nicola   +2 more
core   +1 more source

A space-time conditional intensity model for infectious disease occurence [PDF]

, 2010
A novel point process model continuous in space-time is proposed for infectious disease data. Modelling is based on the conditional intensity function (CIF) and extends an additive-multiplicative CIF model previously proposed for discrete space epidemic ...
Assunçáo, Daley, Diggle, Diggle, Diggle, Elias, Hawkes, Held, Höhle, Höhle, Höhle, Höhle, Jensen, Jewell, Mohler, Neal, Nocedal, Ogata, Ogata, Ogata, Peng, Rathbun, Rosenstein, Scheel, Stroud, Trotter, Zangwill   +26 more
core   +3 more sources

Effects of regional differences and demography in modelling foot-and-mouth disease in cattle at the national scale [PDF]

, 2019
Foot-and-mouth disease (FMD) is a fast-spreading viral infection that can produce large and costly outbreaks in livestock populations. Transmission occurs at multiple spatial scales, as can the actions used to control outbreaks. The US cattle industry is
Beck-Johnson, Lindsay M., Hallman, Clayton, Lindström, Tom, Miller, Ryan S., Murrieta, Deedra J., Portacci, Katie, Sellman, Stefan, Tildesley, Michael J., Tsao, Kimberly, Webb, Colleen T.   +9 more
core   +1 more source

Response strategies for COVID-19 epidemics in African settings: a mathematical modelling study

BMC Medicine, 2020
Background The health impact of COVID-19 may differ in African settings as compared to countries in Europe or China due to demographic, epidemiological, environmental and socio-economic factors.
Kevin van Zandvoort, Christopher I. Jarvis, Carl A. B. Pearson, Nicholas G. Davies, CMMID COVID-19 working group, Ruwan Ratnayake, Timothy W. Russell, Adam J. Kucharski, Mark Jit, Stefan Flasche, Rosalind M. Eggo, Francesco Checchi   +11 more
doaj   +1 more source

Combined population dynamics and entropy modelling supports patient stratification in chronic myeloid leukemia [PDF]

, 2016
Modelling the parameters of multistep carcinogenesis is key for a better understanding of cancer progression, biomarker identification and the design of individualized therapies.
Brehme, Marc, Brümmendorf, Tim H,, Copland, Mhairi, Koschmieder, Steffen, Montazeri, Maryam, Oehler, Vivian G., Radich, Jerald P., Schuppert, Andreas   +7 more
core   +1 more source

Cost-effectiveness of routine adolescent vaccination with an M72/AS01E-like tuberculosis vaccine in South Africa and India

Nature Communications, 2022
The M72/AS01E tuberculosis vaccine has shown 50% efficacy in preventing pulmonary TB disease in infected 18–50 year olds. Here, the authors demonstrate that, in most scenarios modelled, vaccination of adolescents would also be cost effective in two high ...
Rebecca C. Harris, Matthew Quaife, Chathika Weerasuriya, Gabriela B. Gomez, Tom Sumner, Fiammetta Bozzani, Richard G. White   +6 more
doaj   +1 more source