Results 31 to 40 of about 666,620 (307)
Cellular models of Batten disease
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, 2020 The Neuronal Ceroid Lipofuscinoses (NCL), otherwise known as Batten disease, are a group of neurodegenerative diseases caused by mutations in 13 known genes. All except one NCL is autosomal recessive in inheritance, with similar aetiology and characterised by the accumulation of autofluorescent storage material in the lysosomes of cells.
Minnis, CJ +3 more
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Mathematical modelling of the pathogenesis of multiple myeloma-induced bone disease [PDF]
, 2014 Multiple myeloma (MM) is the second most common haematological malignancy and results in destructive bone lesions. The interaction between MM cells and the bone microenvironment plays an important role in the development of the tumour cells and MM ...
Blum B +6 more
core +1 more source
BMC Infectious Diseases, 2017 Background The international spread of wild poliomyelitis outbreaks continues to threaten eradication of poliomyelitis and in 2014 a public health emergency of international concern was declared.
Kathleen M. O’Reilly +5 more
doaj +1 more source
Molecular Autism, 2020 The complex pathophysiology of autism spectrum disorder encompasses interactions between genetic and environmental factors. On the one hand, hundreds of genes, converging at the functional level on selective biological domains such as epigenetic ...
Cristina Cheroni +2 more
doaj +1 more source
Vaccines, 2021 New tuberculosis vaccines have made substantial progress in the development pipeline. Previous modelling suggests that adolescent/adult mass vaccination may cost-effectively contribute towards achieving global tuberculosis control goals.
Chathika Krishan Weerasuriya +5 more
doaj +1 more source
Graph Theory and Networks in Biology [PDF]
, 2006 In this paper, we present a survey of the use of graph theoretical techniques in Biology. In particular, we discuss recent work on identifying and modelling the structure of bio-molecular networks, as well as the application of centrality measures to ...
Mason, Oliver, Verwoerd, Mark
core +3 more sources
Parathyroid Diseases and Animal Models [PDF]
Frontiers in Endocrinology, 2012 CIRCULATING CALCIUM AND PHOSPHATE ARE TIGHTLY REGULATED BY THREE HORMONES: the active form of vitamin D (1,25-dihydroxyvitamin D), fibroblast growth factor (FGF)-23, and parathyroid hormone (PTH). PTH acts to stimulate a rapid increment in serum calcium and has a crucial role in calcium homeostasis. Major target organs of PTH are kidney and bone.
Imanishi, Yasuo +2 more
openaire +3 more sources
Epidemics, 2023 Infectious disease models are widely used by epidemiologists to improve the understanding of transmission dynamics and disease natural history, and to predict the possible effects of interventions.
Danny Scarponi +11 more
doaj +1 more source
A service oriented approach for guidelines-based clinical decision support using BPMN [PDF]
, 2014 Evidence-based medical practice requires that clinical guidelines need to be documented in such a way that they represent a clinical workflow in its most accessible form.
Aziz, Ayesha +2 more
core +1 more source
Data needs for integrated economic-epidemiological models of pandemic mitigation policies
Epidemics, 2022 The COVID-19 pandemic and the mitigation policies implemented in response to it have resulted in economic losses worldwide. Attempts to understand the relationship between economics and epidemiology has led to a new generation of integrated mathematical ...
David J. Haw +6 more
doaj +1 more source