Results 11 to 20 of about 666,620 (307)

Health and economic burden of respiratory syncytial virus (RSV) disease and the cost-effectiveness of potential interventions against RSV among children under 5 years in 72 Gavi-eligible countries

open access: yesBMC Medicine, 2020
Background Respiratory syncytial virus (RSV) frequently causes acute lower respiratory infection in children under 5, representing a high burden in Gavi-eligible countries (mostly low-income and lower-middle-income).
Xiao Li   +5 more
doaj   +1 more source

Cancer disease: integrative modelling approaches [PDF]

open access: yes, 2006
Cancer is a complex disease in which a variety of phenomena interact over a wide range of spatial and temporal scales. In this article a theoretical framework will be introduced that is capable of linking together such processes to produce a detailed ...
Alarcon, T   +4 more
core   +1 more source

A Quantitative Systems Pharmacology Model of Gaucher Disease Type 1 Provides Mechanistic Insight Into the Response to Substrate Reduction Therapy With Eliglustat

open access: yesCPT: Pharmacometrics & Systems Pharmacology, 2020
Gaucher’s disease type 1 (GD1) leads to significant morbidity and mortality through clinical manifestations, such as splenomegaly, hematological complications, and bone disease.
Ruth Abrams   +15 more
doaj   +1 more source

The impact of local and national restrictions in response to COVID-19 on social contacts in England: a longitudinal natural experiment

open access: yesBMC Medicine, 2021
Background England’s COVID-19 response transitioned from a national lockdown to localised interventions. In response to rising cases, these were supplemented by national restrictions on contacts (the Rule of Six), then 10 pm closing for bars and ...
Christopher I. Jarvis   +5 more
doaj   +1 more source

Effects of regional differences and demography in modelling foot-and-mouth disease in cattle at the national scale [PDF]

open access: yes, 2019
Foot-and-mouth disease (FMD) is a fast-spreading viral infection that can produce large and costly outbreaks in livestock populations. Transmission occurs at multiple spatial scales, as can the actions used to control outbreaks. The US cattle industry is
Beck-Johnson, Lindsay M.   +9 more
core   +1 more source

Modelling Future Coronary Heart Disease Mortality to 2030 in the British Isles. [PDF]

open access: yes, 2015
OBJECTIVE: Despite rapid declines over the last two decades, coronary heart disease (CHD) mortality rates in the British Isles are still amongst the highest in Europe.
A Martin   +37 more
core   +8 more sources

Disease Mapping via Negative Binomial Regression M-quantiles [PDF]

open access: yes, 2013
We introduce a semi-parametric approach to ecological regression for disease mapping, based on modelling the regression M-quantiles of a Negative Binomial variable. The proposed method is robust to outliers in the model covariates, including those due to
Chambers, Ray   +2 more
core   +1 more source

Response strategies for COVID-19 epidemics in African settings: a mathematical modelling study

open access: yesBMC Medicine, 2020
Background The health impact of COVID-19 may differ in African settings as compared to countries in Europe or China due to demographic, epidemiological, environmental and socio-economic factors.
Kevin van Zandvoort   +11 more
doaj   +1 more source

Multiscale modeling in disease

open access: yesCurrent Opinion in Systems Biology, 2021
Multiscale computational modeling aims to connect the complex networks of effects at different length and/or time scales. For example, these networks often include intracellular molecular signaling, crosstalk, and other interactions between neighboring cell populations, and higher levels of emergent phenomena across different regions of tissues and ...
openaire   +2 more sources

Animal Models of Human Disease

open access: yesInternational Journal of Molecular Sciences, 2023
The use of animal models of human disease is critical for furthering our understanding of disease mechanisms, for the discovery of novel targets for treatment, and for translational research. This Special Topic entitled “Animal Models of Human Disease” aimed to collect state-of-the-art primary research studies and review articles from international ...
Lange, Sigrun, Inal, Jameel
openaire   +3 more sources

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