Results 11 to 20 of about 1,930,568 (317)
Research Models for Studying Vascular Calcification [PDF]
, 2020 Calcification of the vessel wall contributes to high cardiovascular morbidity and mortality. Vascular calcification (VC) is a systemic disease with multifaceted contributing and inhibiting factors in an actively regulated process.
Babic, Milen +4 more
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Animal models of neurodegenerative diseases [PDF]
Nature Neuroscience, 2018 Animal models of adult-onset neurodegenerative diseases have enhanced the understanding of the molecular pathogenesis of Alzheimer's disease, Parkinson's disease, frontotemporal dementia, and amyotrophic lateral sclerosis. Nevertheless, our understanding of these disorders and the development of mechanistically designed therapeutics can still benefit ...
Ted M. Dawson +2 more
openaire +2 more sources
Viruses, 2022 Pulmonary microbial invasion frequently occurs during AIDS progression in HIV patients. Inflammatory cytokines and other immunoregulatory factors play important roles in this process.
Ying Lu +6 more
doaj +1 more source
Animal models of Wilson disease [PDF]
Journal of Neurochemistry, 2018 AbstractWilson disease (WD) is an autosomal recessive disorder of copper metabolism manifesting with hepatic, neurological and psychiatric symptoms. The limitations of the currently available therapy for WD (particularly in the management of neuropsychiatric disease), together with our limited understanding of key aspects of this illness (e.g ...
Emily Reed +2 more
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Similarities and differences in placental development between humans and cynomolgus monkeys
Reproductive Medicine and Biology, 2023 Background The placenta is an extraembryonic organ, which is essential to maintain a normal pregnancy. However, placental development in humans is poorly understood because of technical and ethical reasons. Methods We analyzed the anatomical localization
Shoma Matsumoto +3 more
doaj +1 more source
Animal Models of Huntington's Disease [PDF]
ILAR Journal, 2007 Huntington's disease (HD) is a neurological disorder caused by a genetic mutation in the IT15 gene. Progressive cell death in the striatum and cortex, and accompanying declines in cognitive, motor, and psychiatric functions, are characteristic of the disease.
Shilpa, Ramaswamy +2 more
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Functional genomics elucidates regulatory mechanisms of Parkinson’s disease-associated variants
BMC Medicine, 2022 Background Genome-wide association studies (GWASs) have identified multiple risk loci for Parkinson’s disease (PD). However, identifying the functional (or potential causal) variants in the reported risk loci and elucidating their roles in PD ...
Rui Chen +8 more
doaj +1 more source
Animal Models of Parkinson's Disease [PDF]
Parkinson's Disease, 2011 Parkinson's disease (PD) is considered a multifactorial disorder, which is neuropathologically characterized by age-dependent neurodegeneration of dopaminergic neurons in the midbrain. Different neurotoxins including synthetic compounds, heavy metals, and dopamine itself have been proposed to be environmental risk factors of PD.
Yuzuru Imai +4 more
openaire +3 more sources
Animal Models of Cardiovascular Diseases [PDF]
BioMed Research International, 2011 Cardiovascular diseases are the first leading cause of death and morbidity in developed countries. The use of animal models have contributed to increase our knowledge, providing new approaches focused to improve the diagnostic and the treatment of these pathologies.
Zaragoza, Carlos +9 more
openaire +3 more sources
Circadian Disruption and Metabolic Disease: Findings from Animal Models [PDF]
, 2010 Social opportunities and work demands have caused humans to become increasingly active during the late evening hours, leading to a shift from the predominantly diurnal lifestyle of our ancestors to a more nocturnal one.
Arble, Deanna M. +3 more
core +2 more sources