Results 31 to 40 of about 1,196,955 (314)

Animal models of soft-tissue sarcoma. [PDF]

, 2010
Soft-tissue sarcomas (STSs) are rare mesenchymal tumors that arise from muscle, fat and connective tissue. Currently, over 75 subtypes of STS are recognized.
Kirsch, David G, Rebecca D. Dodd, Dodd, Rebecca D, Jeffery K. Mito, Mito, Jeffery K, David G. Kirsch   +5 more
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WDR73 Depletion Destabilizes PIP4K2C Activity and Impairs Focal Adhesion Formation in Galloway–Mowat Syndrome

Biology, 2022
(1) Background: Galloway–Mowat syndrome (GAMOS) is a rare genetic disease, classically characterized by a combination of various neurological symptoms and nephrotic syndrome. WDR73 is the pathogenic gene responsible for GAMOS1.
Hongyan Li, Fang Liu, Hanzhe Kuang, Hua Teng, Siyi Chen, Sijing Zeng, Qimin Zhou, Zhaokai Li, Desheng Liang, Zhuo Li, Lingqian Wu   +10 more
doaj   +1 more source

A novel biomechanical analysis of gait changes in the MPTP mouse model of Parkinson’s disease [PDF]

, 2015
Parkinson's disease (PD) is an age-associated neurodegenerative disorder hallmarked by a loss of mesencephalic dopaminergic neurons. Accurate recapitulation of the PD movement phenotype in animal models of the disease is critical for understanding ...
Geldenhuys, Werner, Pienaar, Ilse, Young, Jesse, Dean E. Dluzen, Werner J. Geldenhuys, Tamara L. Guseman, Ilse S. Pienaar, Jesse W. Young, Dluzen, Dean, Guseman, Tamara   +9 more
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Monkeys mutant for PKD1 recapitulate human autosomal dominant polycystic kidney disease

Nature Communications, 2019
Most cases of autosomal dominant polycystic kidney disease (ADPKD) are due to mutations in PKD1. Here, Tsukiyama et al. generate monkeys with mutations in PKD1 and show that animals recapitulate key pathological features of the human disease, suggesting ...
Tomoyuki Tsukiyama, Kenichi Kobayashi, Masataka Nakaya, Chizuru Iwatani, Yasunari Seita, Hideaki Tsuchiya, Jun Matsushita, Kahoru Kitajima, Ikuo Kawamoto, Takahiro Nakagawa, Koji Fukuda, Teppei Iwakiri, Hiroyuki Izumi, Iori Itagaki, Shinji Kume, Hiroshi Maegawa, Ryuichi Nishinakamura, Saori Nishio, Shinichiro Nakamura, Akihiro Kawauchi, Masatsugu Ema   +20 more
doaj   +1 more source

Animal Models for Crimean-Congo Hemorrhagic Fever Human Disease [PDF]

, 2019
Crimean-Congo hemorrhagic fever virus (CCHFV) is an important tick-borne human pathogen endemic throughout Asia, Africa and Europe. CCHFV is also an emerging virus, with recent outbreaks in Western Europe.
Darci R. Smith, Joseph W. Golden, Aura R. Garrison   +2 more
core   +1 more source

Disease models in cerebral cavernous malformations [PDF]

, 2020
Cerebral cavernous malformation (CCM) is a rare disease of genetic origin characterized by dilated and leaky capillaries occurring mainly in the central nervous system.
Trabalzini L., Glading A. J., Finetti F.
core   +1 more source

The impact of movements and animal density on continental scale cattle disease outbreaks in the United States [PDF]

, 2014
Globalization has increased the potential for the introduction and spread of novel pathogens over large spatial scales necessitating continental-scale disease models to guide emergency preparedness.
Michael J. Tildesley (123224), Miller, Ryan S., Miller, Ryan S.,, Werkman, Marleen,, Buhnerkempe, Michael G.,, Katie Portacci (106341), Grear, Daniel A., Wennergren, Uno,, Lindström, Tom,, Webb, Colleen T.,, Katie Portacci, Keeling, Matt J., Werkman, Marleen, Buhnerkempe, Michael, Colleen T Webb, Lindström, Tom, Jason E. Lombard (543387), Lombard, Jason E., Tom Lindström, Michael J Tildesley, Grear, Daniel A.,, Keeling, Matt J.,, Wennergren, Uno, Colleen T. Webb (106335), Matt J. Keeling (251596), Ryan S. Miller (106337), Tom Lindström (106326), Webb, Colleen T., Marleen Werkman (543388), Portacci, Katie, Lombard, Jason E.,, Keeling, Matthew James, Jason E Lombard, Michael G. Buhnerkempe (212445), Tildesley, Michael J., Daniel A Grear, Daniel A. Grear (106330), Buhnerkempe, Michael G., Marleen Werkman, Portacci, Katie,, Uno Wennergren (106344), Ryan S Miller, Matt J Keeling, Uno Wennergren, Michael G Buhnerkempe, Tildesley, Michael J.,   +45 more
core   +1 more source

Isolation of Joint-infiltrating Cells

Bio-Protocol, 2016
Infiltration of leukocytes into joints is one of the main features of autoimmune inflammatory arthritis. Here, we describe the protocol for isolation of joint-infiltrating cells in mice.
Aoi Akitsu, Yoichiro Iwakura
doaj   +1 more source

Cohesin promotes HSV-1 lytic transcription by facilitating the binding of RNA Pol II on viral genes

Virology Journal, 2021
Background Herpes Simplex Virus type I (HSV-1) is a large double-stranded DNA virus that enters productive infection in epithelial cells and reorganizes the host nucleus.
Xin Li, Yafen Yu, Fengchao Lang, Guijun Chen, Erlin Wang, Lihong Li, Zhuoran Li, Liping Yang, Xia Cao, Nigel W. Fraser, Jumin Zhou   +10 more
doaj   +1 more source

Animal Models for Henipavirus Research [PDF]

, 2023
Hendra virus (HeV) and Nipah virus (NiV) are zoonotic paramyxoviruses in the genus Henipavirus (HNV) that emerged nearly thirty years ago. Outbreaks of HeV and NiV have led to severe respiratory disease and encephalitis in humans and animals ...
Courtney Woolsey, Declan D. Pigeaud, Thomas W. Geisbert   +2 more
core   +1 more source