Results 31 to 40 of about 16,121,002 (311)

Cohesin promotes HSV-1 lytic transcription by facilitating the binding of RNA Pol II on viral genes

Virology Journal, 2021
Background Herpes Simplex Virus type I (HSV-1) is a large double-stranded DNA virus that enters productive infection in epithelial cells and reorganizes the host nucleus.
Xin Li, Yafen Yu, Fengchao Lang, Guijun Chen, Erlin Wang, Lihong Li, Zhuoran Li, Liping Yang, Xia Cao, Nigel W. Fraser, Jumin Zhou   +10 more
doaj   +1 more source

Isolation of Joint-infiltrating Cells

Bio-Protocol, 2016
Infiltration of leukocytes into joints is one of the main features of autoimmune inflammatory arthritis. Here, we describe the protocol for isolation of joint-infiltrating cells in mice.
Aoi Akitsu, Yoichiro Iwakura
doaj   +1 more source

Identification of a psychiatric risk gene NISCH at 3p21.1 GWAS locus mediating dendritic spine morphogenesis and cognitive function

BMC Medicine, 2023
Background Schizophrenia and bipolar disorder (BD) are believed to share clinical symptoms, genetic risk, etiological factors, and pathogenic mechanisms.
Zhi-Hui Yang, Xin Cai, Zhong-Li Ding, Wei Li, Chu-Yi Zhang, Jin-Hua Huo, Yue Zhang, Lu Wang, Lin-Ming Zhang, Shi-Wu Li, Ming Li, Chen Zhang, Hong Chang, Xiao Xiao   +13 more
doaj   +1 more source

Animal models in neurodegenerative diseases [PDF]

, 2007
Ideally, animal models of neurodegenerative diseases should reproduce the clinical manifestation of the disease and a selective neuronal loss. In this review we will take as an example Parkinson's disease because its pathophysiology is well known and the neuronal loss well characterized.
openaire   +3 more sources

Editorial : experimental models of asthma [PDF]

, 2008
Since 2002, a workshop entitled “Asthma in animal models” has been held once a year in Hannover, Germany. It is organized by the Fraunhofer Institute of Toxicology and Experimental Medicine in collaboration with the collaborative research centre ...
Thomas Tschernig, David A Groneberg, Tschernig, Thomas, Braun, Armin, Groneberg, Jan David Alexander, Armin Braun, Groneberg, D.A., Braun, A., Tschernig, T.   +8 more
core   +1 more source

Centipede Venoms and Their Components: Resources for Potential Therapeutic Applications

Toxins, 2015
Venomous animals have evolved with sophisticated bio-chemical strategies to arrest prey and defend themselves from natural predators. In recent years, peptide toxins from venomous animals have drawn considerable attention from researchers due to their ...
Md Abdul Hakim, Shilong Yang, Ren Lai
doaj   +1 more source

Animal Models for Periodontal Disease [PDF]

BioMed Research International, 2011
Animal models and cell cultures have contributed new knowledge in biological sciences, including periodontology. Although cultured cells can be used to study physiological processes that occur during the pathogenesis of periodontitis, the complex host response fundamentally responsible for this disease cannot be reproduced
Oz, Helieh S., Puleo, David A.
openaire   +2 more sources

Sequential infection with H1N1 and SARS-CoV-2 aggravated COVID-19 pathogenesis in a mammalian model, and co-vaccination as an effective method of prevention of COVID-19 and influenza

Signal Transduction and Targeted Therapy, 2021
Influenza A virus may circulate simultaneously with the SARS-CoV-2 virus, leading to more serious respiratory diseases during this winter. However, the influence of these viruses on disease outcome when both influenza A and SARS-CoV-2 are present in the ...
Linlin Bao, Wei Deng, Feifei Qi, Qi Lv, Zhiqi Song, Jiangning Liu, Hong Gao, Qiang Wei, Pin Yu, Yanfeng Xu, Yajin Qu, Fengdi Li, Jing Xue, Shuran Gong, Mingya Liu, Guanpeng Wang, Shunyi Wang, Binbin Zhao, Bin Cong, Chuan Qin   +19 more
doaj   +1 more source

Animal models of autoimmune diseases [PDF]

Rheumatology International, 1997
Failure of distinction between self and non-self is regarded a critical event in the pathogenesis of several human diseases such as systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, myasthenia gravis, uveoretinitis or diabetes mellitus.
Burkhardt, H., Kalden, J. R.
openaire   +2 more sources

Animal Models of Human Disease 2.0 [PDF]

The use of animal models is crucial for advancing translational research by identifying effective treatment targets and strategies for clinical application in human disease [...
Inal, Jameel, Jameel M. Inal, Lange, Sigrun, Inal, Jameel M., Sigrun Lange   +4 more
core   +1 more source