Results 21 to 30 of about 16,121,002 (311)

Animal Models of Parkinson's Disease [PDF]

Parkinson's Disease, 2011
Parkinson's disease (PD) is considered a multifactorial disorder, which is neuropathologically characterized by age-dependent neurodegeneration of dopaminergic neurons in the midbrain. Different neurotoxins including synthetic compounds, heavy metals, and dopamine itself have been proposed to be environmental risk factors of PD.
Yuzuru Imai, Katerina Venderova, David S. Park, Huaibin Cai, Enrico Schmidt   +4 more
openaire   +3 more sources

Animal Models of Cardiovascular Diseases [PDF]

BioMed Research International, 2011
Cardiovascular diseases are the first leading cause of death and morbidity in developed countries. The use of animal models have contributed to increase our knowledge, providing new approaches focused to improve the diagnostic and the treatment of these pathologies.
Zaragoza, Carlos, Gomez-Guerrero, Carmen, Martin-Ventura, Jose Luis, Blanco-Colio, Luis, Lavín Plaza, Begoña, Mallavia, Beñat, Tarin, Carlos, Mas, Sebastian, Ortiz, Alberto, Egido, Jesus   +9 more
openaire   +3 more sources

Animal Models for Neural Diseases [PDF]

Toxicologic Pathology, 2010
“Animal Models of Neural Disease” was the focus of General Session 5 at a 2010 scientific symposium that was sponsored jointly by the Society of Toxicologic Pathology (STP) and the International Federation of Societies of Toxicologic Pathologists (IFSTP).
Gary W, Jay, Ronald B, Demattos, Edward J, Weinstein, Martin A, Philbert, Ingrid D, Pardo, Tom P, Brown   +5 more
openaire   +2 more sources

Animal models to study the neurological manifestations of the post-COVID-19 condition [PDF]

, 2023
More than 40% of individuals infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have experienced persistent or relapsing multi-systemic symptoms months after the onset of coronavirus disease 2019 (COVID-19).
Serra Gironella, Joan, Mateu, Lourdes, Segalés, Joaquim, Brander, Christian, Usai, Carla   +4 more
core   +1 more source

Consistency of spatial dynamics of HIV-1 and HCV among HIV-1/HCV coinfected drug users in China

BMC Infectious Diseases, 2021
Background As the transmission routes of human immunodeficiency virus type 1 (HIV-1) and hepatitis C virus (HCV) are similar, previous studies based on separate research on HIV-1 and HCV assumed a similar transmission pattern.
Yu Wang, Xin Chen, Mei Ye, Wei Pang, Chiyu Zhang, Si-Dong Xiong, Yong-Tang Zheng   +6 more
doaj   +1 more source

Gain and loss events in the evolution of the apolipoprotein family in vertebrata

BMC Evolutionary Biology, 2019
Background Various apolipoproteins widely distributed among vertebrata play key roles in lipid metabolism and have a direct correlation with human diseases as diagnostic markers.
Jia-Qian Liu, Wen-Xing Li, Jun-Juan Zheng, Qing-Nan Tian, Jing-Fei Huang, Shao-Xing Dai   +5 more
doaj   +1 more source

WDR73 Depletion Destabilizes PIP4K2C Activity and Impairs Focal Adhesion Formation in Galloway–Mowat Syndrome

Biology, 2022
(1) Background: Galloway–Mowat syndrome (GAMOS) is a rare genetic disease, classically characterized by a combination of various neurological symptoms and nephrotic syndrome. WDR73 is the pathogenic gene responsible for GAMOS1.
Hongyan Li, Fang Liu, Hanzhe Kuang, Hua Teng, Siyi Chen, Sijing Zeng, Qimin Zhou, Zhaokai Li, Desheng Liang, Zhuo Li, Lingqian Wu   +10 more
doaj   +1 more source

Do animal health models meet the needs of organic and conventional dairy farmers in Spain and the UK on disease prevention? [PDF]

, 2021
Modelling plays an important role in assessing disease risks and the efficacy of preventative actions. However, the extent to which existing models meet the needs of different groups of dairy farmers around disease prevention is unclear.
Wonfor, Ruth; id_orcid, Blanco Penedo, Isabel, Blanco-Penedo, Isabel, Kipling, Richard P., Wonfor, Ruth, Wonfor, Ruth,, Sveriges lantbruksuniversitet., Kipling, Richard P.,, Blanco Penedo, Isabel,, Ruth Wonfor, Richard P. Kipling, Isabel Blanco-Penedo   +11 more
core   +1 more source

Monkeys mutant for PKD1 recapitulate human autosomal dominant polycystic kidney disease

Nature Communications, 2019
Most cases of autosomal dominant polycystic kidney disease (ADPKD) are due to mutations in PKD1. Here, Tsukiyama et al. generate monkeys with mutations in PKD1 and show that animals recapitulate key pathological features of the human disease, suggesting ...
Tomoyuki Tsukiyama, Kenichi Kobayashi, Masataka Nakaya, Chizuru Iwatani, Yasunari Seita, Hideaki Tsuchiya, Jun Matsushita, Kahoru Kitajima, Ikuo Kawamoto, Takahiro Nakagawa, Koji Fukuda, Teppei Iwakiri, Hiroyuki Izumi, Iori Itagaki, Shinji Kume, Hiroshi Maegawa, Ryuichi Nishinakamura, Saori Nishio, Shinichiro Nakamura, Akihiro Kawauchi, Masatsugu Ema   +20 more
doaj   +1 more source

Accelerated disease progression and robust innate host response in aged SIVmac239-infected Chinese rhesus macaques is associated with enhanced immunosenescence

Scientific Reports, 2017
The elderly population infected with HIV-1 is often characterized by the rapid AIDS progression and poor treatment outcome, possibly because of immunosenescence resulting from both HIV infection and aging.
Hong-Yi Zheng, Ming-Xu Zhang, Min Chen, Jin Jiang, Jia-Hao Song, Xiao-Dong Lian, Ren-Rong Tian, Xiao-Liang Zhang, Lin-Tao Zhang, Wei Pang, Gao-Hong Zhang, Yong-Tang Zheng   +11 more
doaj   +1 more source