Results 41 to 50 of about 1,196,955 (314)

Accelerated disease progression and robust innate host response in aged SIVmac239-infected Chinese rhesus macaques is associated with enhanced immunosenescence

Scientific Reports, 2017
The elderly population infected with HIV-1 is often characterized by the rapid AIDS progression and poor treatment outcome, possibly because of immunosenescence resulting from both HIV infection and aging.
Hong-Yi Zheng, Ming-Xu Zhang, Min Chen, Jin Jiang, Jia-Hao Song, Xiao-Dong Lian, Ren-Rong Tian, Xiao-Liang Zhang, Lin-Tao Zhang, Wei Pang, Gao-Hong Zhang, Yong-Tang Zheng   +11 more
doaj   +1 more source

Identification of a psychiatric risk gene NISCH at 3p21.1 GWAS locus mediating dendritic spine morphogenesis and cognitive function

BMC Medicine, 2023
Background Schizophrenia and bipolar disorder (BD) are believed to share clinical symptoms, genetic risk, etiological factors, and pathogenic mechanisms.
Zhi-Hui Yang, Xin Cai, Zhong-Li Ding, Wei Li, Chu-Yi Zhang, Jin-Hua Huo, Yue Zhang, Lu Wang, Lin-Ming Zhang, Shi-Wu Li, Ming Li, Chen Zhang, Hong Chang, Xiao Xiao   +13 more
doaj   +1 more source

Centipede Venoms and Their Components: Resources for Potential Therapeutic Applications

Toxins, 2015
Venomous animals have evolved with sophisticated bio-chemical strategies to arrest prey and defend themselves from natural predators. In recent years, peptide toxins from venomous animals have drawn considerable attention from researchers due to their ...
Md Abdul Hakim, Shilong Yang, Ren Lai
doaj   +1 more source

Animal models in neurodegenerative diseases [PDF]

, 2007
Ideally, animal models of neurodegenerative diseases should reproduce the clinical manifestation of the disease and a selective neuronal loss. In this review we will take as an example Parkinson's disease because its pathophysiology is well known and the neuronal loss well characterized.
openaire   +3 more sources

Animal models for bone tissue engineering and modelling disease [PDF]

, 2018
Tissue engineering and its clinical application, regenerative medicine, are instructing multiple approaches to aid in replacing bone loss after defects caused by trauma or cancer.
McGovern, JA, Griffin, M, Dietmar Werner Hutmacher, Hutmacher, Dietmar, McGovern, Jacqui, Hutmacher, Dietmar Werner, Griffin, Michelle, Hutmacher, DW, Jacqui Anne McGovern, Michelle Griffin, McGovern, Jacqui Anne   +10 more
core   +1 more source

Application of neurotoxin and pesticide induced animal models of Parkinson’s disease in the evaluation of new drug delivery systems [PDF]

, 2021
Parkinson’s disease (PD) is the second most prevalent neuro-degenerative disease after Alzheimer´s disease. It is characterized by motor symptoms such as akinesia, bradykinesia, tremor, rigidity, and postural abnormalities, due to the loss of nigral ...
Barcia Hernández, Emilia María, Casanova Yaquelin, Negro Álvarez, María Sofía Elisa   +2 more
core   +1 more source

The Advent of the Golden Era of Animal Alternatives [PDF]

, 2014
The first years of the beginning 21st century have seen an unparalleled progress in biomedical sciences. Several dogmata that haunted scientific debate for decades were easily abandoned, and there is a fundamental shift away from eminence-based toward ...
Butzke,D., Kugler,J., Seiler,A., Sittner,D., Oelgeschlager,M., Liebsch,M., Luch,A., Grune,B.   +7 more
core   +1 more source

Animal and cell models for Lesch-Nyhan syndrome [PDF]

, 2020
Lesch–Nyhan Disease (LND) is a rare X-linked recessive metabolic and neurological syndrome due to the deficiency of hypoxanthine-guanine phosphoribosyltransferase (HPRT).
Santucci A., Bernardini G., Micheli V., Jacomelli G.   +3 more
core   +1 more source

Sequential infection with H1N1 and SARS-CoV-2 aggravated COVID-19 pathogenesis in a mammalian model, and co-vaccination as an effective method of prevention of COVID-19 and influenza

Signal Transduction and Targeted Therapy, 2021
Influenza A virus may circulate simultaneously with the SARS-CoV-2 virus, leading to more serious respiratory diseases during this winter. However, the influence of these viruses on disease outcome when both influenza A and SARS-CoV-2 are present in the ...
Linlin Bao, Wei Deng, Feifei Qi, Qi Lv, Zhiqi Song, Jiangning Liu, Hong Gao, Qiang Wei, Pin Yu, Yanfeng Xu, Yajin Qu, Fengdi Li, Jing Xue, Shuran Gong, Mingya Liu, Guanpeng Wang, Shunyi Wang, Binbin Zhao, Bin Cong, Chuan Qin   +19 more
doaj   +1 more source

Bidirectional genetic overlap between bipolar disorder and intelligence

BMC Medicine, 2022
Background Bipolar disorder (BD) is a highly heritable psychiatric illness exhibiting substantial correlation with intelligence. Methods To investigate the shared genetic signatures between BD and intelligence, we utilized the summary statistics from ...
Meng-Yuan Shang, Yong Wu, Chu-Yi Zhang, Hao-Xiang Qi, Qing Zhang, Jin-Hua Huo, Lu Wang, Chuang Wang, Ming Li   +8 more
doaj   +1 more source