The Axis of Progression of Disease [PDF]
Cancer Informatics, 2014 Starting with genetic or environmental perturbations, disease progression can involve a linear sequence of changes within individual cells. More often, however, a labyrinth of branching consequences emanates from the initial events. How can one repair an entity so fine and so complex that its organization and functions are only partially known?
Tartakoff, Alan M, Wu, Di
openaire +5 more sources
Progression of glomerular diseases [PDF]
Journal of Internal Medicine, 1994 Abstract. The nature and slope of progression of glomerular diseases is the subject of considerable discussion. The use of renal biopsies has been accompanied by considerable improvement in the classification of glomerular disease. However, the clinical and histological tools available to assess prognosis in individual patients lack accuracy ...
E. P. Peten, L. J. Striker
openaire +3 more sources
Combined population dynamics and entropy modelling supports patient stratification in chronic myeloid leukemia [PDF]
, 2016 Modelling the parameters of multistep carcinogenesis is key for a better understanding of cancer progression, biomarker identification and the design of individualized therapies.
Brehme, Marc +7 more
core +1 more source
Biomarkers of Disease Progression [PDF]
, 2012 After being informed about a diagnosis of multiple sclerosis (MS), patients are often concerned about the risk of disease progression and future prognosis. Many are naturally concerned over the future course, severity of the disease, and likely disability.
Axel Petzold, Axel Petzold
openaire +5 more sources
Rapid Breast Cancer Disease Progression Following Cyclin Dependent Kinase 4 and 6 Inhibitor Discontinuation. [PDF]
, 2017 Background: CDK 4 and 6 inhibitors (CDK4/6i), which arrest unregulated cancer cell proliferation, show clinical efficacy in breast cancer. Unexpectedly, a patient treated on a CDK4/6i-based trial, as first-line therapy in metastatic breast cancer ...
Abouharb, Sausan +12 more
core +2 more sources
Lighter serum copper isotopic composition in patients with early non-alcoholic fatty liver disease [PDF]
, 2020 Objective The occurrence of non-alcoholic fatty liver disease (NAFLD) is globally increasing. To challenge the current incidence of NAFLD, non-invasive markers that could identify patients at risk or monitor disease progression are an important need ...
Costas Rodriguez, Marta +6 more
core +1 more source
Invariant NKT cells contribute to chronic lymphocytic leukemia surveillance and prognosis [PDF]
, 2017 Chronic lymphocytic leukemia (CLL) is characterized by the expansion of malignant CD5(+) B lymphocytes in blood, bone marrow and lymphoid organs. CD1d-restricted invariant Natural Killer T (iNKT) cells are innate-like T lymphocytes strongly implicated in
Azzimonti, Laura +17 more
core +1 more source
DPVis: Visual Analytics with Hidden Markov Models for Disease Progression Pathways
, 2020 Clinical researchers use disease progression models to understand patient status and characterize progression patterns from longitudinal health records.
Anand, Vibha +7 more
core +1 more source
Intraocular Pressure Fluctuation: Is It Important? [PDF]
, 2018 Elevated intraocular pressure (IOP) is a major risk factor for the development and progression of glaucoma. Previous prospective, randomized, long-term studies have demonstrated the strength of IOP reduction in slowing the progression of disease.
Caprioli, Joseph, Kim, Ji Hyun
core +2 more sources
The role of changes in extracellular matrix of cartilage in the presence of inflammation on the pathology of osteoarthritis. [PDF]
, 2013 Osteoarthritis (OA) is a degenerative disease that affects various tissues surrounding joints such as articular cartilage, subchondral bone, synovial membrane, and ligaments.
Maldonado, Maricela, Nam, Jin
core +3 more sources