Results 1 to 10 of about 2,597,964 (377)

DPVis: Visual Analytics with Hidden Markov Models for Disease Progression Pathways [PDF]

open access: yes, 2019
Clinical researchers use disease progression models to understand patient status and characterize progression patterns from longitudinal health records. One approach for disease progression modeling is to describe patient status using a small number of states that represent distinctive distributions over a set of observed measures. Hidden Markov models
Anand, Vibha   +7 more
arxiv   +3 more sources

Leveraging Disease Progression Learning for Medical Image Recognition [PDF]

open access: yesIEEE International Conference on Bioinformatics and Biomedicine (BIBM) 2018, 2018
Unlike natural images, medical images often have intrinsic characteristics that can be leveraged for neural network learning. For example, images that belong to different stages of a disease may continuously follow a certain progression pattern. In this paper, we propose a novel method that leverages disease progression learning for medical image ...
Fevens, Thomas, Lao, Qicheng, Wang, Boyu
arxiv   +3 more sources

A dynamic network approach for the study of human phenotypes [PDF]

open access: yes, 2009
The use of networks to integrate different genetic, proteomic, and metabolic datasets has been proposed as a viable path toward elucidating the origins of specific diseases. Here we introduce a new phenotypic database summarizing correlations obtained from the disease history of more than 30 million patients in a Phenotypic Disease Network (PDN).
A Barrat   +35 more
arxiv   +7 more sources

Alteration in ocular blood flow and its effect on the progression of glaucoma [PDF]

open access: yesGuoji Yanke Zazhi, 2017
Glaucoma is a multifactorial neurodegenerative disease that can result in permanent vision loss by damaging optic nerves due to higher pressure in the eye.
Sher Zaman Safi   +6 more
doaj   +1 more source

The Axis of Progression of Disease [PDF]

open access: yesCancer Informatics, 2014
Starting with genetic or environmental perturbations, disease progression can involve a linear sequence of changes within individual cells. More often, however, a labyrinth of branching consequences emanates from the initial events. How can one repair an entity so fine and so complex that its organization and functions are only partially known?
Tartakoff, Alan M, Wu, Di
openaire   +5 more sources

Expression of p63 as predictive and prognostic factor in advanced non-small-cell lung cancer [PDF]

open access: yesVojnosanitetski Pregled, 2018
Background/Aim. Serbia belongs to the group of countries with a high lung cancer incidence and mortality rate. p63 gene plays an important role in development of lung cancer and immunohistochemical expression of p63 is considered to be a reliable marker ...
Cvetković Gordana   +8 more
doaj   +1 more source

A Phase II Study to Evaluate the Safety and Efficacy of Prasinezumab in Early Parkinson's Disease (PASADENA): Rationale, Design, and Baseline Data

open access: yesFrontiers in Neurology, 2021
Background: Currently available treatments for Parkinson's disease (PD) do not slow clinical progression nor target alpha-synuclein, a key protein associated with the disease.Objective: The study objective was to evaluate the efficacy and safety of ...
Gennaro Pagano   +342 more
doaj   +1 more source

Histamine index and clinical expression of rheumatoid arthritis activity [PDF]

open access: yesVojnosanitetski Pregled, 2010
Background/Aim. Many arguments prove the pathophysiologic role of histamine in the process of remodeling and joint destruction in rheumatoid arthritis.
Tomić-Lučić Aleksandra P.   +4 more
doaj   +1 more source

Clinical and genetic characteristics of Korean autosomal dominant polycystic kidney disease patients [PDF]

open access: yesThe Korean Journal of Internal Medicine, 2021
Autosomal dominant polycystic kidney disease (ADPKD) is the most common hereditary kidney disease. It is characterized by cyst growth in the kidneys, resulting in kidney enlargement and end-stage kidney disease. The polycystic kidney disease 1 (PKD1) and
Yun Kyu Oh   +4 more
doaj   +1 more source

Metabolism and signaling crosstalk in glioblastoma progression and therapy resistance

open access: yesMolecular Oncology, EarlyView., 2023
Glioblastoma is one of the most lethal human cancers with no effective treatment nowadays. Here, we review the increasing amount of evidence supporting the connection between cell signaling deregulation and metabolic reprogramming as a key event in glioblastoma resistance to cancer therapy.
Laura Zarzuela   +2 more
wiley   +1 more source

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