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Predicting Severe Disease and Critical Illness on Initial Diagnosis of COVID-19: Simple Triage Tools

Frontiers in Medicine, 2022
RationaleThis study was conducted to develop, validate, and compare prediction models for severe disease and critical illness among symptomatic patients with confirmed COVID-19.MethodsFor development cohort, 433 symptomatic patients diagnosed with COVID ...
Lutfi Ali S. Kurban, Sharina AlDhaheri, Abdulbaset Elkkari, Ramzi Khashkhusha, Shaikha AlEissaee, Amna AlZaabi, Mohamed Ismail, Omran Bakoush   +7 more
doaj   +1 more source

Apathy in Alzheimer's disease: Contribution to a clinical view on progression of dementia

Dementia & Neuropsychologia
In addition to cognitive impairment, apathy is increasingly recognized as an important neuropsychiatric syndrome in Alzheimer's disease (AD). Aims: To identify the relationship between dementia severity and apathy levels, and to discuss the association ...
Florindo Stella, Larissa Pires de Andrade, Thays Martins Vital, Flávia Gomes de Melo Coelho, Carla Manuela Crispim Nascimento, Salma Stephany Soleman Hernández   +5 more
doaj   +1 more source

Measuring coral disease lesions: a comparison of methodologies

Frontiers in Marine Science
The presence of stressors, particularly disease, on corals necessitates assessments of their severity in order to compare threat levels and to plan for impacts. Diseases in particular are often measured via the rate at which a lesion moves across a coral
Karen L. Neely
doaj   +1 more source

Why neurodegenerative diseases are progressive: uncontrolled inflammation drives disease progression [PDF]

Trends in Immunology, 2008
Neurodegenerative diseases are a group of chronic, progressive disorders characterized by the gradual loss of neurons in discrete areas of the central nervous system (CNS). The mechanism(s) underlying their progressive nature remains unknown but a timely and well-controlled inflammatory reaction is essential for the integrity and proper function of the
Hui-Ming, Gao, Jau-Shyong, Hong
openaire   +2 more sources

Prevalence of Hepatitis B co-infection amongst HIV infected children attending a care and treatment centre in Owerri, South-eastern Nigeria

The Pan African Medical Journal, 2013
INTRODUCTION: Hepatitis B infection impacts negatively on disease progression in HIV infected children thereby increasing morbidity and mortality. In spite of the foregoing, data on Hepatitis B co-infection in children living with HIV in South Eastern ...
Emeka Nwolisa, Francis Mbanefo, Joseph Ezeogu, Paul Amadi   +3 more
doaj   +1 more source

The serologic decoy receptor 3 (DcR3) levels are associated with slower disease progression in HIV-1/AIDS patients

Journal of the Formosan Medical Association, 2015
The decoy receptor 3 (DcR3) is a member of the tumor necrosis factor receptor (TNFR) super-family. It counteracts the biological effects of Fas ligands and inhibits apoptosis.
Yu-Ting Lin, Chia-Hung Yen, Heng-Li Chen, Yi-Jen Liao, I-Feng Lin, Marcelo Chen, Yu-Ching Lan, Shao-Yuan Chuang, Shie-Liang Hsieh, Yi-Ming Arthur Chen   +9 more
doaj   +1 more source

Extent of lung fibrosis is of greater prognostic importance than HRCT pattern in patients with progressive pulmonary fibrosis: data from the ILD-PRO registry

Respiratory Research
Background The prognostic value of patterns and quantitative measures of lung fibrosis on high-resolution computed tomography (HRCT) in patients identified as having progressive pulmonary fibrosis (PPF) has not been established.
Aparna C. Swaminathan, Jeremy M. Weber, Jamie L. Todd, Scott M. Palmer, Megan L. Neely, Timothy P. Whelan, Grace Hyun J. Kim, Thomas B. Leonard, Jonathan Goldin   +8 more
doaj   +1 more source

JAK/STAT pathway: Extracellular signals, diseases, immunity, and therapeutic regimens

Frontiers in Bioengineering and Biotechnology, 2023
Janus kinase/signal transduction and transcription activation (JAK/STAT) pathways were originally thought to be intracellular signaling pathways that mediate cytokine signals in mammals.
Qian Hu, Qian Hu, Qian Hu, Qian Hu, Qihui Bian, Dingchao Rong, Leiyun Wang, Leiyun Wang, Leiyun Wang, Jianan Song, Hsuan-Shun Huang, Jun Zeng, Jie Mei, Jie Mei, Jie Mei, Peng-Yuan Wang   +15 more
doaj   +1 more source

Cerebrospinal fluid inflammatory biomarkers for disease progression in Alzheimer’s disease and multiple sclerosis: a systematic review

Frontiers in Immunology, 2023
Inflammatory processes are involved in the pathophysiology of both Alzheimer’s disease (AD) and multiple sclerosis (MS) but their exact contribution to disease progression remains to be deciphered.
Joke Temmerman, Joke Temmerman, Joke Temmerman, Sebastiaan Engelborghs, Sebastiaan Engelborghs, Sebastiaan Engelborghs, Maria Bjerke, Maria Bjerke, Maria Bjerke, Maria Bjerke, Miguel D’haeseleer, Miguel D’haeseleer, Miguel D’haeseleer   +12 more
doaj   +1 more source

Leflunomide plus low-dose prednisone in patients with progressive IgA nephropathy: a multicenter, prospective, randomized, open-labeled, and controlled trial

Renal Failure, 2021
Background Immunoglobulin A nephropathy (IgAN) is the most common cause of glomerulonephritis worldwide, and the optimal approach to its treatment remains a significant challenge.
Zhaohui Ni, Zhen Zhang, Zanzhe Yu, Fuming Lu, Changlin Mei, Xiaoqiang Ding, Weijie Yuan, Wei Zhang, Gengru Jiang, Min Sun, Liqun He, Yueyi Deng, Huihua Pang, Jiaqi Qian   +13 more
doaj   +1 more source