Results 251 to 260 of about 1,384,630 (286)

Gut microbiome synthesizes important core metabolites to prevent cognitive decline and mitigate onset and progression of Alzheimer's disease

Nouf S. Al-Abbas, Nehad A. Shaer
openalex   +1 more source

HSP70 governs permeability and mechanotransduction in primary human endothelial cells

FEBS Open Bio, EarlyView.
HSP70 chemical inhibition reduces endothelial cell proliferation and increases permeability, the latter supported by normal interendothelial junctional protein distribution. HSP70 also plays a role in shear stress response, a hemodynamic force naturally present in blood vessels and correlated with vessel protection.
Andrea Pinto‐Martinez, Everton G. Melo, Isadora C. B. Pavan, Percíllia V. S. Oliveira, Luiza B. C. T. Coimbra, Thaís L. S. Araujo   +5 more
wiley   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

Thrombolytic proteins profiling: High‐throughput activity, selectivity, and resistance assays

FEBS Open Bio, EarlyView.
We present optimized biochemical protocols for evaluating thrombolytic proteins, enabling rapid and robust screening of enzymatic activity, inhibition resistance, and fibrin affinity, stimulation, and selectivity. The outcome translates to key clinical indicators such as biological half‐life and bleeding risk. These assays streamline the development of
Martin Toul, Alan Strunga, Jiri Damborsky, Zbynek Prokop   +3 more
wiley   +1 more source

Saliva IL6 Upregulation As a Potential Indicator of Tobacco-Smoke Associated OSCC and Disease Progression and the Association of Saliva RELA(p65) Upregulation With OSCC Local Invasion in Non-Smokers

Dimitra P. Vageli, Panagiotis G. Doukas, Banjamin Judson   +2 more
openalex   +1 more source

Altered dynamics of T cell subsets in peripheral blood impacts disease progression in newly diagnosed multiple myeloma

Mohini Vig, Lalit Kumar, Shweta Dubey, Ritu Gupta   +3 more
openalex   +1 more source

Disease progression from mild cognitive impairment to dementia for patients with Alzheimer's disease or Lewy body pathology

Guogen Shan, Yahui Zhang
openalex   +1 more source

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Periodontal Disease Progression

Journal of Periodontology, 2000
Background: The objective of this investigation is to use noninvasive, state‐of‐the‐art, diagnostic techniques to measure periodontal disease progression and model periodontal disease activity over time. In this investigation, digital subtraction radiography and an electronic controlled force periodontal probe capable of attachment level measurement ...
M S, Reddy, N C, Geurs, R L, Jeffcoat, H, Proskin, M K, Jeffcoat   +4 more
openaire   +2 more sources

Progressive Conduction Diseases

Cardiac Electrophysiology Clinics, 2010
Progressive cardiac conduction disease (PCCD), a source of considerable morbidity, comprises a heterogeneous group of conditions resulting from genetic predisposition, environmental modifiers, and other physiologic determinants, including aging. The genetic factors include numerous mutations and variants within the cardiac sodium channel gene, SCN5A ...
Claire A, Martin, Christopher L-H, Huang, Andrew A, Grace   +2 more
openaire   +2 more sources

Progress in Alzheimer’s disease

Journal of Neurology, 2011
After more than one century from Alois Alzheimer and Gaetano Perusini's first report, progress has been made in understanding the pathogenic steps of Alzheimer's disease (AD), as well as in its early diagnosis. This review discusses recent findings leading to the formulation of novel criteria for diagnosis of the disease even in a preclinical phase, by
D. Galimberti, E. Scarpini
openaire   +3 more sources