Results 251 to 260 of about 12,599,414 (356)

Association of Autonomic Dysfunction With Disease Progression and Survival in Parkinson Disease

JAMA Neurology, 2017
E. de Pablo-Fernández, C. Tur, T. Révész, A. Lees, J. Holton, T. Warner   +5 more
semanticscholar   +1 more source

Endoglin mediates the tumor‐ and metastasis‐promoting traits of stromal myofibroblasts in human breast carcinomas

Molecular Oncology, EarlyView.
Carcinoma‐associated fibroblasts (CAFs) in tumors influence cancer progression. We identified endoglin (ENG) as a key factor in TGF‐β signaling in myofibroblastic CAFs (myCAFs), linked to poor breast cancer outcomes. Inhibiting ENG on myCAFs suppressed the TGF‐β‐Smad2/3 pathway, reducing primary tumor growth and metastasis.
Shoki Okubo, Yoshihiro Mezawa, Zixu Wang, Ahmet Acar, Yasuhiko Ito, Atsushi Takano, Yohei Miyagi, Tomoyuki Yokose, Toshinari Yamashita, Yataro Daigo, Takuya Shirakihara, Akira Orimo   +11 more
wiley   +1 more source

Wrist accelerometry and machine learning sensitively capture disease progression in prodromal Parkinson's disease. [PDF]

NPJ Parkinsons Dis
Gupta AS, Patel S.
europepmc   +1 more source

Integrative miRNOMe profiling reveals the miR‐195‐5p–CHEK1 axis and its impact on luminal breast cancer outcomes

Molecular Oncology, EarlyView.
In luminal (ER+) breast carcinoma (BC), miRNA profiling identified miR‐195‐5p as a key regulator of proliferation that targets CHEK1, CDC25A, and CCNE1. High CHEK1 expression correlates with worse relapse‐free survival after chemotherapy, especially in patients with luminal A subtype.
Veronika Boušková, Marie Ehrlichová, Alžběta Spálenková, Ivona Krus, Simona Šůsová, Viktor Hlaváč, Vlasta Němcová, Renata Koževnikovová, Markéta Trnková, David Vrána, Jiří Gatěk, Kateřina Kopečková, Marcela Mrhalová, Soňa Měšťáková, Pavel Souček   +14 more
wiley   +1 more source

The Confluence of HIV-1 and HIV-2: Implications for Disease Progression and Insights for Therapy. [PDF]

Int J Microbiol
Magomere E, Olwal CO, Tetteh BE, Appeaning M, Ndung'u T, Kyei GB, Quashie PK.   +6 more
europepmc   +1 more source

Serum concentration of intercellular adhesion molecule–1 in patients with hepatocellular carcinoma is a marker of the disease progression and prognosis [PDF]

, 1995
Yukihiro Shimizu, Masami Minemura, Takashi Tsukishiro, Yoshirou Kashii, Megumi Miyamoto, Hiroshi Nishimori, Kiyohiro Higuchi, Akiharu Watanabe   +7 more
openalex   +1 more source

Association of high‐dose radioactive iodine therapy with PPM1D‐mutated clonal hematopoiesis in older individuals

Molecular Oncology, EarlyView.
In thyroid cancer patients, high‐dose (≥7.4 GBq) radioactive iodine therapy (RAIT) was associated with a higher prevalence of clonal hematopoiesis (variant allele frequency >2%) in individuals aged ≥50 years (OR = 2.44). In silico analyses showed that truncating PPM1D mutations conferred a selective advantage under these conditions.
Jaeryuk Kim, Sungwoo Bae, Jaeyong Choi, Sun‐Wha Im, Bukyoung Cha, Gyeongseo Jung, Sun Wook Cho, Eul‐Ju Seo, Young Ah Lee, Jin Chul Paeng, Young Joo Park, Jong‐Il Kim   +11 more
wiley   +1 more source

Developing serum proteomics based prediction models of disease progression in ADPKD. [PDF]

Nat Commun
Aydogan Balaban HÖ, Arjune S, Grundmann F, Lackmann JW, Rauen T, Antczak P, Müller RU.   +6 more
europepmc   +1 more source

Encephalopathy and progression of human immunodeficiency virus disease in a cohort of children with perinatally acquired human immunodeficiency virus infection

, 1998
Ellen R. Cooper, Celine Hanson, Clemente Díaz, Hermann Mendez, Rasha Abboud, Rachel Nugent, Jane Pitt, Kenneth Rich, Evelyn M. Rodriguez, Vincent L. Smeriglio   +9 more
openalex   +1 more source

Tubulo-interstitial damage in glomerular diseases: its role in the progression of the renal damage [PDF]

, 1998
Giuseppe D’Amico
openalex   +1 more source