Results 21 to 30 of about 12,637,526 (357)

Leflunomide plus low-dose prednisone in patients with progressive IgA nephropathy: a multicenter, prospective, randomized, open-labeled, and controlled trial

Renal Failure, 2021
Background Immunoglobulin A nephropathy (IgAN) is the most common cause of glomerulonephritis worldwide, and the optimal approach to its treatment remains a significant challenge.
Zhaohui Ni, Zhen Zhang, Zanzhe Yu, Fuming Lu, Changlin Mei, Xiaoqiang Ding, Weijie Yuan, Wei Zhang, Gengru Jiang, Min Sun, Liqun He, Yueyi Deng, Huihua Pang, Jiaqi Qian   +13 more
doaj   +1 more source

Risk factors associated with disease progression in a cohort of patients infected with the 2019 novel coronavirus.

Annals of Palliative Medicine, 2020
BACKGROUND The emerging infection of the 2019 novel coronavirus (2019-nCoV) in late December, 2019 in Wuhan, China, has caused an extreme health concern, with many patients having progressed to acute respiratory disease or other complications in a short ...
Yu-Long Zhou, Zhicheng Zhang, Jie Tian, Shaoyun Xiong   +3 more
semanticscholar   +1 more source

Risk factors for disease progression in hospitalized patients with COVID-19: a retrospective cohort study

Infectious Diseases, 2020
Background: To investigate the risk factors related to aggravation and clinical outcomes in coronavirus disease 2019 (COVID-19) patients. Methods: We performed a retrospective study on the risk factors for disease progression of cases with COVID-19 ...
W. Hou, Wei Zhang, R. Jin, Lian-chun Liang, Bin Xu, Zhongjie Hu   +5 more
semanticscholar   +1 more source

Drosophila as a Model Organism in Host–Pathogen Interaction Studies

Frontiers in Cellular and Infection Microbiology, 2020
Owing to the genetic similarities and conserved pathways between a fruit fly and mammals, the use of the Drosophila model as a platform to unveil novel mechanisms of infection and disease progression has been justified and widely instigated.
Salma Younes, Asma Al-Sulaiti, Elham Abdulwahab Ahmed Nasser, Hoda Najjar, Layla Kamareddine   +4 more
doaj   +1 more source

Landscape analysis for a neonatal disease progression model of bronchopulmonary dysplasia: Leveraging clinical trial experience and real-world data

Frontiers in Pharmacology, 2022
The 21st Century Cures Act requires FDA to expand its use of real-world evidence (RWE) to support approval of previously approved drugs for new disease indications and post-marketing study requirements.
Jeffrey S. Barrett, Megan Cala Pane, Timothy Knab, William Roddy, Jack Beusmans, Eric Jordie, Kanwaljit Singh, Jonathan Michael Davis, Klaus Romero, Michael Padula, Bernard Thebaud, Mark Turner   +11 more
doaj   +1 more source

Data-Driven Sequence of Changes to Anatomical Brain Connectivity in Sporadic Alzheimer’s Disease

Frontiers in Neurology, 2017
Model-based investigations of transneuronal spreading mechanisms in neurodegenerative diseases relate the pattern of pathology severity to the brain’s connectivity matrix, which reveals information about how pathology propagates through the connectivity ...
Neil P. Oxtoby, Sara Garbarino, Nicholas C. Firth, Nicholas C. Firth, Jason D. Warren, Jonathan M. Schott, Daniel C. Alexander, For the Alzheimer’s Disease Neuroimaging Initiative   +7 more
doaj   +1 more source

Clinical characteristics and analysis of risk factors for disease progression of patients with SARS-CoV-2 Omicron variant infection: A retrospective study of 25207 cases in a Fangcang hospital

Frontiers in Cellular and Infection Microbiology, 2022
ObjectivesTo summarize the clinical characteristics of patients infected by SARS-CoV-2 omicron variant and explore the risk factors affecting the progression in a Fangcang hospital, Shanghai, China.MethodsA total of 25,207 patients were retrospectively ...
Pei Ying-hao, Gu Yuan-yuan, Zhang Hai-dong, Chen Qiu-hua, Gu Xue-ran, Zhou Hai-qi, Jiang Hua   +6 more
doaj   +1 more source

Circulating tumor cells, disease progression, and survival in metastatic breast cancer.

New England Journal of Medicine, 2004
BACKGROUND We tested the hypothesis that the level of circulating tumor cells can predict survival in metastatic breast cancer. METHODS In a prospective, multicenter study, we tested 177 patients with measurable metastatic breast cancer for levels of ...
M. Cristofanilli, G. Budd, M. Ellis, A. Stopeck, J. Matera, M. Miller, J. Reuben, G. Doyle, W. Allard, L. Terstappen, D. Hayes   +10 more
semanticscholar   +1 more source

Biomarkers of inflammation and repair in kidney disease progression.

Journal of Clinical Investigation, 2020
INTRODUCTION Acute kidney injury and chronic kidney disease (CKD) are common in hospitalized patients. To inform clinical decision-making, more accurate information regarding risk of long-term progression to kidney failure is required.
Jeremy Puthumana, H. Thiessen-Philbrook, Leyuan Xu, S. Coca, A. Garg, J. Himmelfarb, P. Bhatraju, T. Ikizler, E. Siew, L. Ware, Kathleen D. Liu, A. Go, J. Kaufman, P. Kimmel, V. Chinchilli, L. Cantley, C. Parikh   +16 more
semanticscholar   +1 more source

Rapid Breast Cancer Disease Progression Following Cyclin Dependent Kinase 4 and 6 Inhibitor Discontinuation. [PDF]

, 2017
Background: CDK 4 and 6 inhibitors (CDK4/6i), which arrest unregulated cancer cell proliferation, show clinical efficacy in breast cancer. Unexpectedly, a patient treated on a CDK4/6i-based trial, as first-line therapy in metastatic breast cancer ...
Abouharb, Sausan, Bashour, Sami I, Brown, Powel H, Doostan, Iman, Ibrahim, Nuhad K, Karuturi, Meghan, Keyomarsi, Khandan, Koenig, Kimberly B, Litton, Jennifer K, Moulder-Thompson, Stacy L, Tripathy, Debasish, Ueno, Naoto T, Valero, Vicente   +12 more
core   +2 more sources