Results 21 to 30 of about 1,384,630 (286)

DPVis: Visual Analytics with Hidden Markov Models for Disease Progression Pathways

, 2020
Clinical researchers use disease progression models to understand patient status and characterize progression patterns from longitudinal health records.
Anand, Vibha,, Frohnert, Brigitte I.,, Ghosh, Soumya,, Kwon, Bum Chul,, Lund University., Lund University., Lundgren, Markus,, Ng, Kenney,, Severson, Kristen A.,, Sun, Zhaonan,   +9 more
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Invariant NKT cells contribute to chronic lymphocytic leukemia surveillance and prognosis [PDF]

, 2017
Chronic lymphocytic leukemia (CLL) is characterized by the expansion of malignant CD5(+) B lymphocytes in blood, bone marrow and lymphoid organs. CD1d-restricted invariant Natural Killer T (iNKT) cells are innate-like T lymphocytes strongly implicated in
Azzimonti, Laura, Bellone, Matteo, Bertilaccio, Maria Teresa, Caligaris Cappio, Federico, Capri, Miriam, Casorati, Giulia, de Lalla, Claudia, Delfanti, Gloria, Dellabona, Paolo, DI NAPOLI, Arianna, Doglioni, Claudio, Franceschi, Claudio, Ghia, Paolo, Gorini, Francesca, Gulino, Alessandro, Ranghetti, Pamela, Scarfò, Lydia, Scielzo, Cristina   +17 more
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Landscape analysis for a neonatal disease progression model of bronchopulmonary dysplasia: Leveraging clinical trial experience and real-world data

Frontiers in Pharmacology, 2022
The 21st Century Cures Act requires FDA to expand its use of real-world evidence (RWE) to support approval of previously approved drugs for new disease indications and post-marketing study requirements.
Jeffrey S. Barrett, Megan Cala Pane, Timothy Knab, William Roddy, Jack Beusmans, Eric Jordie, Kanwaljit Singh, Jonathan Michael Davis, Klaus Romero, Michael Padula, Bernard Thebaud, Mark Turner   +11 more
doaj   +1 more source

Multi-stage Biomarker Models for Progression Estimation in Alzheimer’s Disease [PDF]

, 2015
The estimation of disease progression in Alzheimer’s disease (AD) based on a vector of quantitative biomarkers is of high interest to clinicians, patients, and biomedical researchers alike.
Alejandro F. Frangi, Alexander Schmidt-Richberg, Christian Ledig, Daniel Rueckert, Helena Molina-Abril, null null, Ricardo Guerrero   +6 more
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A high cerebrospinal fluid soluble TREM2 level is associated with slow clinical progression of Alzheimer's disease

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2020
Introduction The progression rate of Alzheimer's disease (AD) varies and might be affected by the triggering receptor expressed on myeloid cells (TREM2) activity.
Trine Holt Edwin, Kristi Henjum, Lars N.G. Nilsson, Leiv Otto Watne, Karin Persson, Rannveig Sakshaug Eldholm, Ingvild Saltvedt, Nathalie Bodd Halaas, Geir Selbæk, Knut Engedal, Bjørn Heine Strand, Anne‐Brita Knapskog   +11 more
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Risk Factors for Long-Term Coronary Artery Calcium Progression in the Multi-Ethnic Study of Atherosclerosis. [PDF]

, 2015
BackgroundCoronary artery calcium (CAC) detected by noncontrast cardiac computed tomography scanning is a measure of coronary atherosclerosis burden. Increasing CAC levels have been strongly associated with increased coronary events.
Blaha, Michael J, Budoff, Matthew, Gassett, Amanda J, Kaufman, Joel D, Kronmal, Richard, McClelland, Robyn L, Olives, Casey, Sheppard, Lianne   +7 more
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Rapidly Progressive Alzheimer Disease [PDF]

Archives of Neurology, 2011
Different rates of progression have been observed among patients with Alzheimer disease. Risk factors that accelerate deterioration have been identified and some are being discussed, such as genetics, comorbidity, and the early appearance of Alzheimer disease motor signs.
Christian, Schmidt, Martin, Wolff, Michael, Weitz, Thomas, Bartlau, Carsten, Korth, Inga, Zerr   +5 more
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Progression of glomerular diseases [PDF]

Journal of Internal Medicine, 1994
Abstract. The nature and slope of progression of glomerular diseases is the subject of considerable discussion. The use of renal biopsies has been accompanied by considerable improvement in the classification of glomerular disease. However, the clinical and histological tools available to assess prognosis in individual patients lack accuracy ...
E P, Peten, L J, Striker
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Classification of Pediatric Asthma: From Phenotype Discovery to Clinical Practice

Frontiers in Pediatrics, 2018
Advances in big data analytics have created an opportunity for a step change in unraveling mechanisms underlying the development of complex diseases such as asthma, providing valuable insights that drive better diagnostic decision-making in clinical ...
Ceyda Oksel, Sadia Haider, Sara Fontanella, Clement Frainay, Clement Frainay, Adnan Custovic   +5 more
doaj   +1 more source

Human phosphodiesterase 4D7 (PDE4D7) expression is increased in TMPRSS2-ERG positive primary prostate cancer and independently adds to a reduced risk of post-surgical disease progression [PDF]

, 2015
background: There is an acute need to uncover biomarkers that reflect the molecular pathologies, underpinning prostate cancer progression and poor patient outcome.
Baillie, G. S., Bottcher, R., Dulla, K., Henderson, D. J. P., Hoffmann, R., Houslay, M. D., Jenster, G., Lehman, M. L., Merkle, D., Tevz, G., van Leenders, G. J. L. H., van Strijp, D., Waanders, L. F.   +12 more
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