Results 21 to 30 of about 12,789,497 (387)

Utility of laboratory and immune biomarkers in predicting disease progression and mortality among patients with moderate to severe COVID-19 disease at a Philippine tertiary hospital

Frontiers in Immunology, 2023
PurposeThis study was performed to determine the clinical biomarkers and cytokines that may be associated with disease progression and in-hospital mortality in a cohort of hospitalized patients with RT-PCR confirmed moderate to severe COVID-19 infection ...
Felix Eduardo R. Punzalan, Felix Eduardo R. Punzalan, Jaime Alfonso M. Aherrera, Jaime Alfonso M. Aherrera, Sheriah Laine M. de Paz-Silava, Alric V. Mondragon, Alric V. Mondragon, Anna Flor G. Malundo, Anna Flor G. Malundo, Joanne Jennifer E. Tan, Joanne Jennifer E. Tan, Ourlad Alzeus G. Tantengco, Ourlad Alzeus G. Tantengco, Elgin Paul B. Quebral, Mary Nadine Alessandra R. Uy, Mary Nadine Alessandra R. Uy, Ryan C. V. Lintao, Jared Gabriel L. Dela Rosa, Maria Elizabeth P. Mercado, Krisha Camille Avenilla, Jonnel B. Poblete, Albert B. Albay, Albert B. Albay, Aileen S. David-Wang, Aileen S. David-Wang, Marissa M. Alejandria, Marissa M. Alejandria, Marissa M. Alejandria   +27 more
doaj   +1 more source

Cortical hyperexcitability evolves with disease progression in ALS

Annals of Clinical and Translational Neurology, 2020
Cortical hyperexcitability has been established as an early feature of amyotrophic lateral sclerosis (ALS). The evolution of cortical hyperexcitability with ALS progression remains to be fully elucidated.
P. Menon, M. Higashihara, M. V. D. van den Bos, N. Geevasinga, M. Kiernan, S. Vucic   +5 more
semanticscholar   +1 more source

Rapid Breast Cancer Disease Progression Following Cyclin Dependent Kinase 4 and 6 Inhibitor Discontinuation. [PDF]

, 2017
Background: CDK 4 and 6 inhibitors (CDK4/6i), which arrest unregulated cancer cell proliferation, show clinical efficacy in breast cancer. Unexpectedly, a patient treated on a CDK4/6i-based trial, as first-line therapy in metastatic breast cancer ...
Abouharb, Sausan, Bashour, Sami I, Brown, Powel H, Doostan, Iman, Ibrahim, Nuhad K, Karuturi, Meghan, Keyomarsi, Khandan, Koenig, Kimberly B, Litton, Jennifer K, Moulder-Thompson, Stacy L, Tripathy, Debasish, Ueno, Naoto T, Valero, Vicente   +12 more
core   +2 more sources

Invariant NKT cells contribute to chronic lymphocytic leukemia surveillance and prognosis [PDF]

, 2017
Chronic lymphocytic leukemia (CLL) is characterized by the expansion of malignant CD5(+) B lymphocytes in blood, bone marrow and lymphoid organs. CD1d-restricted invariant Natural Killer T (iNKT) cells are innate-like T lymphocytes strongly implicated in
Azzimonti, Laura, Bellone, Matteo, Bertilaccio, Maria Teresa, Caligaris Cappio, Federico, Capri, Miriam, Casorati, Giulia, de Lalla, Claudia, Delfanti, Gloria, Dellabona, Paolo, DI NAPOLI, Arianna, Doglioni, Claudio, Franceschi, Claudio, Ghia, Paolo, Gorini, Francesca, Gulino, Alessandro, Ranghetti, Pamela, Scarfò, Lydia, Scielzo, Cristina   +17 more
core   +1 more source

Evolution of lung pathology in lymphangioleiomyomatosis: associations with disease course and treatment response

The Journal of Pathology: Clinical Research, 2020
Lymphangioleiomyomatosis (LAM) is a rare multisystem disease with a variable clinical course. The lungs are infiltrated by nodules of LAM cells, stromal cells and inflammatory cells, causing lung cysts and respiratory failure. We used immunohistochemical
Suzanne Miller, Iain D Stewart, Debbie Clements, Irshad Soomro, Roya Babaei‐Jadidi, Simon R Johnson   +5 more
doaj   +1 more source

Intraocular Pressure Fluctuation: Is It Important? [PDF]

, 2018
Elevated intraocular pressure (IOP) is a major risk factor for the development and progression of glaucoma. Previous prospective, randomized, long-term studies have demonstrated the strength of IOP reduction in slowing the progression of disease.
Caprioli, Joseph, Kim, Ji Hyun
core   +2 more sources

Reconstructing cell cycle and disease progression using deep learning

Nature Communications, 2017
We show that deep convolutional neural networks combined with nonlinear dimension reduction enable reconstructing biological processes based on raw image data.
P. Eulenberg, Niklas D. Koehler, Thomas Blasi, A. Filby, Anne E Carpenter, Paul Rees, Paul Rees, Fabian J Theis, F. A. Wolf   +8 more
semanticscholar   +1 more source

Uremic Toxins in the Progression of Chronic Kidney Disease and Cardiovascular Disease: Mechanisms and Therapeutic Targets

Toxins, 2021
Chronic kidney disease (CKD) is a progressive loss of renal function. The gradual decline in kidney function leads to an accumulation of toxins normally cleared by the kidneys, resulting in uremia. Uremic toxins are classified into three categories: free
Y. J. Lim, Nicole A. Sidor, Nicholas C Tonial, Adrian Che, B. Urquhart   +4 more
semanticscholar   +1 more source

DPVis: Visual Analytics with Hidden Markov Models for Disease Progression Pathways

, 2020
Clinical researchers use disease progression models to understand patient status and characterize progression patterns from longitudinal health records.
Anand, Vibha, Frohnert, Brigitte I, Ghosh, Soumya, Kwon, Bum Chul, Lundgren, Markus, Ng, Kenney, Severson, Kristen A, Sun, Zhaonan   +7 more
core   +1 more source

IFNα and IFNγ Impede Marek’s Disease Progression [PDF]

, 2019
Marek’s disease virus (MDV) is an alphaherpesvirus that causes Marek’s disease, a malignant lymphoproliferative disease of domestic chickens. While MDV vaccines protect animals from clinical disease, they do not provide sterilizing immunity and allow ...
Bertzbach, Luca D., Fehler, Frank, Harlin, Olof, Härtle, Sonja, Kaspers, Bernd, Kaufer, Benedikt B., Vychodil, Tereza   +6 more
core   +1 more source