Results 51 to 60 of about 3,016,766 (291)

The serologic decoy receptor 3 (DcR3) levels are associated with slower disease progression in HIV-1/AIDS patients

Journal of the Formosan Medical Association, 2015
The decoy receptor 3 (DcR3) is a member of the tumor necrosis factor receptor (TNFR) super-family. It counteracts the biological effects of Fas ligands and inhibits apoptosis.
Yu-Ting Lin, Chia-Hung Yen, Heng-Li Chen, Yi-Jen Liao, I-Feng Lin, Marcelo Chen, Yu-Ching Lan, Shao-Yuan Chuang, Shie-Liang Hsieh, Yi-Ming Arthur Chen   +9 more
doaj   +1 more source

Speech and language therapy versus placebo or no intervention for speech problems in Parkinson's disease [PDF]

, 2012
Parkinson's disease patients commonly suffer from speech and vocal problems including dysarthric speech, reduced loudness and loss of articulation. These symptoms increase in frequency and intensity with progression of the disease).
Brady, Marian C, Clarke, Carl E, Deane, Katherine, Herd, Clare P, Sackley, Catherine M, Smith, Christina H, Tomlinson, Claire L   +6 more
core   +1 more source

Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells

FEBS Letters, EarlyView.
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura, Lixiang Wang, Nao Hasuzawa, Ayako Nagayama, Sawako Moriyama, Kenji Ashida, Yoshinori Moriyama, Masatoshi Nomura, Ken Yamamoto   +8 more
wiley   +1 more source

RAD50 missense variants differentially affect the DNA damage response and mitotic progression

FEBS Letters, EarlyView.
RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker, Swantje Kebel, Lea Völkening, Anna Vatselia, Louisa Weinhold, Girmay Asgedom, Axel Schambach, Detlev Schindler, Thilo Dörk, Kristine Bousset   +9 more
wiley   +1 more source

JAK/STAT pathway: Extracellular signals, diseases, immunity, and therapeutic regimens

Frontiers in Bioengineering and Biotechnology, 2023
Janus kinase/signal transduction and transcription activation (JAK/STAT) pathways were originally thought to be intracellular signaling pathways that mediate cytokine signals in mammals.
Qian Hu, Qian Hu, Qian Hu, Qian Hu, Qihui Bian, Dingchao Rong, Leiyun Wang, Leiyun Wang, Leiyun Wang, Jianan Song, Hsuan-Shun Huang, Jun Zeng, Jie Mei, Jie Mei, Jie Mei, Peng-Yuan Wang   +15 more
doaj   +1 more source

Risk Prediction of a Multiple Sclerosis Diagnosis

, 2013
Multiple sclerosis (MS) is a chronic autoimmune disease that affects the central nervous system. The progression and severity of MS varies by individual, but it is generally a disabling disease.
Ghosh, Joydeep, Ho, Joyce C., Unnikrishnan, KP   +2 more
core   +1 more source

The current state of biomarker research for Friedreich's ataxia: a report from the 2018 FARA biomarker meeting [PDF]

, 2019
The 2018 FARA Biomarker Meeting highlighted the current state of development of biomarkers for Friedreich's ataxia. A mass spectroscopy assay to sensitively measure mature frataxin (reduction of which is the root cause of disease) is being developed ...
Blair, Ian A., Farmer, Jennifer, Hersch, Steven, Larkindale, Jane, Lynch, David R., Napierala, Jill, Napierala, Marek, Payne, R. Mark, Subramony, Sub H.   +8 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Extent of lung fibrosis is of greater prognostic importance than HRCT pattern in patients with progressive pulmonary fibrosis: data from the ILD-PRO registry

Respiratory Research
Background The prognostic value of patterns and quantitative measures of lung fibrosis on high-resolution computed tomography (HRCT) in patients identified as having progressive pulmonary fibrosis (PPF) has not been established.
Aparna C. Swaminathan, Jeremy M. Weber, Jamie L. Todd, Scott M. Palmer, Megan L. Neely, Timothy P. Whelan, Grace Hyun J. Kim, Thomas B. Leonard, Jonathan Goldin   +8 more
doaj   +1 more source

Cerebrospinal fluid inflammatory biomarkers for disease progression in Alzheimer’s disease and multiple sclerosis: a systematic review

Frontiers in Immunology, 2023
Inflammatory processes are involved in the pathophysiology of both Alzheimer’s disease (AD) and multiple sclerosis (MS) but their exact contribution to disease progression remains to be deciphered.
Joke Temmerman, Joke Temmerman, Joke Temmerman, Sebastiaan Engelborghs, Sebastiaan Engelborghs, Sebastiaan Engelborghs, Maria Bjerke, Maria Bjerke, Maria Bjerke, Maria Bjerke, Miguel D’haeseleer, Miguel D’haeseleer, Miguel D’haeseleer   +12 more
doaj   +1 more source