Results 211 to 220 of about 3,031,744 (313)

A species-specific tale of quantitative disease resistance (QDR) in tomato. [PDF]

Plant Cell
Ng PQ.
europepmc   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

A Transmembrane Protein WAI-B2 Confers Multiple Disease Resistance in Wheat by Activating Autoimmunity. [PDF]

Adv Sci (Weinh)
Li W, Chen Y, Dong L, Guo G, Zhang H, Shen T, Wang G, Dong L, Lu P, Li M, Qiu D, Zhu K, Li B, Hou Y, Cui X, Huang B, Yang F, Fu H, Li D, Li Z, Hu J, Qu Y, Lou H, Chen S, Li Z, Kang L, Yang W, Yuan C, Li H, Zhao Y, Liu Z, Jia H, Wu Q.   +32 more
europepmc   +1 more source

Tracking Motor Progression and Device‐Aided Therapy Eligibility in Parkinson's Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterise the progression of motor symptoms and identify eligibility for device‐aided therapies in Parkinson's disease, using both the 5‐2‐1 criteria and a refined clinical definition, while examining differences across genetic subgroups.
David Ledingham, Sahana Sathyanarayana, Charlotte B. Stewart, Robyn Iredale, Victoria Foster, Debra Galley, Mark Baker, Nicola Pavese   +7 more
wiley   +1 more source

The maize mitogen-activated protein kinase kinase kinase gene ZmMAPKKK45 is associated with multiple disease resistance. [PDF]

New Phytol
Zhong T, Olukolu B, Bian Y, Xue S, Wisser RJ, Ojiambo PS, Holland JB, Yang Q, Balint-Kurti P.   +8 more
europepmc   +1 more source

Predicting Epileptogenic Tubers in Patients With Tuberous Sclerosis Complex Using a Fusion Model Integrating Lesion Network Mapping and Machine Learning

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Accurate localization of epileptogenic tubers (ETs) in patients with tuberous sclerosis complex (TSC) is essential but challenging, as these tubers lack distinct pathological or genetic markers to differentiate them from other cortical tubers.
Tinghong Liu, Qi Wang, Suhui Kuang, Dezhi Cao, Ping Ding, Shaohui Zhang, Haihua Wei, Zhirong Wei, Jinshan Xu, Xinyu Huang, Bing Liu, Shuli Liang   +11 more
wiley   +1 more source

Targeting effector proteins of plant pathogens as a strategy for durable plant disease resistance. [PDF]

Front Microbiol
Senthilraja G, Sandhya M, Priyadharshini E, Anand T, Kavitha M, Tharmalingam N.   +5 more
europepmc   +1 more source

Super‐Refractory Status Epilepticus (SRSE) in a Patient With Compound Heterozygous OPA1 Variants: Case Report and Literature Review

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Super‐Refractory Status Epilepticus (SRSE) is a rare, life‐threatening neurological emergency with unclear etiology in many cases. Mitochondrial dysfunction, often due to disease‐causing genetic variants, is increasingly recognized as a cause, with each gene producing distinct pathophysiological mechanisms.
Pouria Mohammadi, Lara Basovic, Christopher Michael McGraw   +2 more
wiley   +1 more source

Integrative GWAS and RNA-seq identify MYL9 as a key regulator of pullorum disease resistance in chickens. [PDF]

Poult Sci
Wu J, Fan Z, Chao X, Liang W, Li R, Chen S, Fang C, Luo Q.   +7 more
europepmc   +1 more source