Results 41 to 50 of about 496,181 (282)

Molecular biomarkers and toxic consequences of impact by organic pollution in aquatic organisms [PDF]

, 1994
Organic contaminants are readily bioaccumulated by aquatic organisms. Exposure to and toxic effects of contaminants can be measured in terms of the biochemical responses of the organisms (i.e. molecular biomarkers).
Förlin, L., George, S.G., Livingston, D.R.   +2 more
core  

Long-term survival for a cohort of adults with cerebral palsy [PDF]

, 2006
The aim of this study was to investigate long-term survival and examine causes of death in adult patients with cerebral palsy (CP). A 1940–1950 birth cohort based on paediatric case referral allows for long-term survival follow-up.
Blair, Cox, Evans, Evans, Hutton, Hutton, Hutton, Jane L Hutton, Karla Hemming, Maudsley, Peter O D Pharoah, Strauss, Strauss, Strauss, Strauss, Surveillance of Cerebral Palsy in Europe., Woods, Woods, Woods   +18 more
core   +1 more source

Interplay between circadian and other transcription factors—Implications for cycling transcriptome reprogramming

FEBS Letters, EarlyView.
This perspective highlights emerging insights into how the circadian transcription factor CLOCK:BMAL1 regulates chromatin architecture, cooperates with other transcription factors, and coordinates enhancer dynamics. We propose an updated framework for how circadian transcription factors operate within dynamic and multifactorial chromatin landscapes ...
Xinyu Y. Nie, Jerome S. Menet
wiley   +1 more source

Dachengqi decoction for the treatment of acute pancreatitis: a comprehensive analysis based on metabolites, pharmacokinetics, and metabolites efficacy mechanisms

Frontiers in Pharmacology
Dachengqi decoction (DCQD) is a traditional Chinese medicine formula consisting of three botanical drugs and one mineral drug. It has anti-inflammatory, gastrointestinal motility, and microcirculation improvement effects.
Wen Guo, Wen Guo, Xiaobin Zhang, Xiaobin Zhang, Xin Zhou, Xin Zhou, Wangpeng Lan, Wangpeng Lan, Jianqin Liu, Yali Liu, Yali Liu, Li Li, Li Li, Zhi Li, Zhi Li, Zhi Li   +15 more
doaj   +1 more source

Large-scale survey to estimate the prevalence of disorders for 192 Kennel Club registered breeds [PDF]

, 2017
Background Pedigree or purebred dogs are often stated to have high prevalence of disorders which are commonly assumed to be a consequence of inbreeding and selection for exaggerated features.
Evans, K M, Lewis, T W, Llewellyn-Zaidi, A M, O'Neill, D G, Wiles, B M   +4 more
core   +2 more sources

Multidimensional OMICs reveal ARID1A orchestrated control of DNA damage, splicing, and cell cycle in normal‐like and malignant urothelial cells

Molecular Oncology, EarlyView.
Loss of the frequently mutated chromatin remodeler ARID1A, a subunit of the SWI/SNF cBAF complex, results in less open chromatin, alternative splicing, and the failure to stop cells from progressing through the cell cycle after DNA damage in bladder (cancer) cells. Created in BioRender. Epigenetic regulators, such as the SWI/SNF complex, with important
Rebecca M. Schlösser, Florian Krumbach, Eyleen Corrales, Geoffroy Andrieux, Christian Preisinger, Franziska Liss, Alexandra Golzmann, Melanie Boerries, Kerstin Becker, Ruth Knüchel, Stefan Garczyk, Bernhard Lüscher   +11 more
wiley   +1 more source

The Relationship between Serum Zinc Level and Liver Elastrography Using Fibroscan in Non-Alcoholic Fatty Liver Patients

Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2018
BACKGROUND AND OBJECTIVE: Zinc is one of the essential elements for many vital functions of the body, including regulation of gene expression, anti-inflammatory and antioxidant activity, protein and nucleic acids metabolism.
E Hajiani, A Parsi, K Erfanian Taghvaie, M Morvaridi   +3 more
doaj  

Infectious diseases as a factor of formation pathology of digestive organs in children

Детские инфекции (Москва), 2019
It has been shown that various infectious diseases can be a factor in the formation and development of pathology of the digestive system organs in children.The literature describes, mainly, the clinical aspect of changes in the organs of the digestive ...
L. S. Kalagina
doaj   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Digestive system diseases: the actual problem of clinical medicine

Gastroenterologìa, 2019
Background. Worldwide, the number of people suffe­ring from gastrointestinal and hepatobiliary diseases is increasing annually, and, therefore, they need specialized gastroenterological assistance.
Yu.M. Stepanov, I.Yu. Skirda, O.P. Petishko   +2 more
doaj   +1 more source