Results 61 to 70 of about 268,573 (327)

Digestive system diseases: the actual problem of clinical medicine

open access: yesGastroenterologìa, 2019
Background. Worldwide, the number of people suffe­ring from gastrointestinal and hepatobiliary diseases is increasing annually, and, therefore, they need specialized gastroenterological assistance.
Yu.M. Stepanov   +2 more
doaj   +1 more source

[Preclinical experience in stem cell therapy for digestive tract diseases].

open access: yesThe Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi, 2011
Adult stem cells are multipotent and self-renewing cells that contain several functions; i) migration and homing potential: stem cells can migrate to injured and inflamed tissues.
Myung-Shin Jeon, Soon-Sun Hong
semanticscholar   +1 more source

Escape from TGF‐β‐induced senescence promotes aggressive hallmarks in epithelial hepatocellular carcinoma cells

open access: yesMolecular Oncology, EarlyView.
Chronic TGF‐β exposure drives epithelial HCC cells from a senescent state to a TGF‐β resistant mesenchymal phenotype. This transition is characterized by the loss of Smad3‐mediated signaling, escape from senescence, enhanced invasiveness and metastatic potential, and upregulation of key resistance modulators such as MARK1 and GRM8, ultimately promoting
Minenur Kalyoncu   +11 more
wiley   +1 more source

Diseases of the Digestive System and Air Pollution

open access: yesThe International Annals of Medicine, 2018
Aim: The aim of this work is to study the diseases of the human digestive system in Cyprus and their relationship to smoking and air pollution. Methods: The statistical methods were used to derive the results of this work are Student t-test in order to check the statistical significance of digestive diseases in relation to gender, One-Way ANOVA test ...
Irene Rethemiotaki, Andrew Rethemiotakis
openaire   +2 more sources

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

open access: yesMolecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau   +11 more
wiley   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

open access: yesMolecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti   +10 more
wiley   +1 more source

Role of yoga in the management of digestive system disorders

open access: yesEnvironment Conservation Journal, 2017
A healthy digestive system is the key to total health. Digestive system diseases contribute a big proportion of all pathologies. Yoga is being recognised worldwide as the solution to these problems.
Manorma Singh
doaj   +1 more source

Targeting the AKT/mTOR pathway attenuates the metastatic potential of colorectal carcinoma circulating tumor cells in a murine xenotransplantation model

open access: yesMolecular Oncology, EarlyView.
Dual targeting of AKT and mTOR using MK2206 and RAD001 reduces tumor burden in an intracardiac colon cancer circulating tumor cell xenotransplantation model. Analysis of AKT isoform‐specific knockdowns in CTC‐MCC‐41 reveals differentially regulated proteins and phospho‐proteins by liquid chromatography coupled mass spectrometry. Circulating tumor cells
Daniel J. Smit   +19 more
wiley   +1 more source

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

open access: yesMolecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson   +11 more
wiley   +1 more source

Liuweizhiji Gegen-Sangshen beverage protects against alcoholic liver disease in mice through the gut microbiota mediated SCFAs/GPR43/GLP-1 pathway

open access: yesFrontiers in Nutrition
IntroductionAlcoholic liver disease (ALD) is a pathological state of the liver caused by longterm alcohol consumption. Recent studies have shown that the modulation of the gut microbiota and its metabolic products, specifically the short-chain fatty ...
Mingyun Tang   +28 more
doaj   +1 more source

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