Macrophage Changes and High‐Throughput Sequencing in Aging Mouse Intervertebral Disks
JOR SPINE, Volume 8, Issue 2, June 2025.We aimed to evaluate caudal IVD specimens from adult and older mice to study M0, M1, and M2 macrophage polarization and their aging‐related secretory phenotypes. Additionally, we aimed to assess macrophage polarization in aged disks, along with the differential expression of genes related to aging, and the hub genes involved in aging.
Wei Wang +7 more
wiley +1 more source
Antibody from mice immunized with DNA encoding the carboxyl-disintegrin and cysteine-rich domain (JD9) of the haemorrhagic metalloprotease, Jararhagin, inhibits the main lethal component of viper venom [PDF]
, 2000 Robert A. Harrison +7 more
openalex +1 more source
JOR SPINE, Volume 8, Issue 2, June 2025.ABSTRACT Background Intervertebral disc (IVD) degeneration (IDD) is the main contributor to chronic low back pain (LBP), the leading cause of disability worldwide, with a significant impact on the quality of life and health of common people. The etiology of IDD is still unclear, but it has been largely demonstrated the crucial role of inflammation and ...
Laura Guarnaccia +20 more
wiley +1 more source
Purification, cloning and sequence analyses for pro‐metalloprotease‐disintegrin variants from Deinagkistrodon acutus venom and subclassification of the small venom metalloproteases [PDF]
, 2000 Inn‐Ho Tsai +4 more
openalex +1 more source
The Role of Adipokines in Spinal Disease: A Narrative Review
JOR SPINE, Volume 8, Issue 2, June 2025.Adipokines, bioactive molecules secreted by adipose tissue, play a key role in both physiological regulation and disease pathogenesis. While their involvement in various organ systems is well documented, their role in spinal pathology remains underexplored.
Jake M. McDonnell +3 more
wiley +1 more source
Liver International Communications, Volume 6, Issue 2, June 2025.ABSTRACT Loss of effective arterial blood volume, secondary hyperaldosteronism, adrenergic activation and nonosmotic hypersecretion of vasopressin induce sodium and water retention in cirrhotic patients with ascites. The mechanisms of sodium retention that precede ascites formation remain elusive.
Giovanni Sansoè +2 more
wiley +1 more source
Human Placental Trophoblasts Secrete a Disintegrin Metalloproteinase Very Similar to the Insulin-Like Growth Factor Binding Protein-3 Protease in Human Pregnancy Serum1 [PDF]
, 2000 Juan C. Irwin +6 more
openalex +1 more source
MedComm, Volume 6, Issue 6, June 2025.ABSTRACT Metastasis is the main cause of cancer‐related deaths and the biggest challenge in improving cancer prognosis. Platelet–tumor cell aggregates are a prerequisite for hematogenous metastasis. However, the internal relation and molecular mechanism of platelets and their receptor glycoprotein (GP) Ibα in platelet–tumor cell interaction and ...
Kangxi Zhou +16 more
wiley +1 more source
The Specific Expression of Three Novel Splice Variant Forms of Human Metalloprotease‐like Disintegrin‐like Cysteine‐rich Protein 2 Gene in Brain Tissues and Glioma [PDF]
, 2000 Taishi Harada +7 more
openalex +1 more source