Results 181 to 190 of about 62,920 (233)
Combined Mutations of LTBP3 and COL5A1A in Geleophysic Dysplasia. [PDF]
Case Rep MedAlsharei A +9 more
europepmc +1 more source
Thrombotic thrombocytopenic purpura in pregnancy: Lessons from a case series of three patients. [PDF]
J Int Med ResElkourashy SA +4 more
europepmc +1 more source
Molecular Cloning of Disintegrin-like Transcript BA-5A from a Bitis arietans Venom Gland cDNA Library: A Putative Intermediate in the Evolution of the Long-Chain Disintegrin Bitistatin [PDF]
Journal of Molecular Evolution, 2006 We report the cloning and sequence analysis of BA-5A from a venom gland cDNA library of the puff adder, Bitis arietans, that encodes a novel ECD-disintegrin-like domain. BA-5A is a unique PII disintegrin.
Juan Calvete +2 more
exaly +2 more sources
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Current Drug Target -Cardiovascular & Hematological Disorders, 2004
The existence of disintegrins, non-enzymatic, small molecular weight proteins from viper venom, has been known for 2 decades, and their impact on cellular research has been substantial and far-reaching. Disintegrins have been the molecular scaffold used in the design of therapeutics for the prevention of thrombosis and cancer.
Mary Ann, McLane +4 more
openaire +2 more sources
The existence of disintegrins, non-enzymatic, small molecular weight proteins from viper venom, has been known for 2 decades, and their impact on cellular research has been substantial and far-reaching. Disintegrins have been the molecular scaffold used in the design of therapeutics for the prevention of thrombosis and cancer.
Mary Ann, McLane +4 more
openaire +2 more sources
Disintegrins in health and disease
Frontiers in Bioscience, 2008Few of the proteins isolated and characterized from snake venom have proven to be more chemically diverse, exquisitely specific or promiscuously active than the family known as disintegrins. These small proteins have shown structural homology with hundreds of cell surface molecules from plants and animals other than snakes, and their precise mimicry of
Mary Ann, McLane +2 more
openaire +2 more sources
Hypertension, 2022
Aortic aneurysm is a complex pathology that can be lethal if not detected in time. Although several molecular mechanisms and pathways have been identified to be involved in aortic aneurysm development and growth, the current lack of an effective pharmacological treatment highlights the need for a more thorough understanding of the factors that regulate
Tolga Kilic +3 more
openaire +2 more sources
Aortic aneurysm is a complex pathology that can be lethal if not detected in time. Although several molecular mechanisms and pathways have been identified to be involved in aortic aneurysm development and growth, the current lack of an effective pharmacological treatment highlights the need for a more thorough understanding of the factors that regulate
Tolga Kilic +3 more
openaire +2 more sources
Anti-Angiogenesis and Disintegrins
2010Angiogenesis is a critical process in tumor and disease progression. A number of features are central to both tumor growth and development, and the recruitment and invasion of a growing vascular network supplying the tumor with nutrients and a mechanism of escape to allow meastatic growth. One class of molecules important to both tumor growth and blood
Stephen Swenson +5 more
openaire +1 more source
2010
Disintegrins represent a class of low molecular weight, Arg-Gly-Asp(RGD)/Lys-Gly-Asp(KGD)-containing, cysteine-rich polypeptides derived from venoms of various viper snakes. They bind to various integrins (e.g. αIIbβ3, αvβ3, α5β1 and others) expressed on cell membrane surface, with various degrees of affinity and specificity.
openaire +1 more source
Disintegrins represent a class of low molecular weight, Arg-Gly-Asp(RGD)/Lys-Gly-Asp(KGD)-containing, cysteine-rich polypeptides derived from venoms of various viper snakes. They bind to various integrins (e.g. αIIbβ3, αvβ3, α5β1 and others) expressed on cell membrane surface, with various degrees of affinity and specificity.
openaire +1 more source
Reduction of the Disintegrin and Metalloprotease ADAM12 in Preeclampsia
Obstetrics & Gynecology, 2005The secreted form of ADAM12 is a metalloprotease that may be involved in placental and fetal growth. We examined whether the concentration of ADAM12 in first-trimester maternal serum could be used as a marker for preeclampsia.We developed a semiautomated, time-resolved, immunofluorometric assay for the quantification of ADAM12 in serum.
Laigaard, Jennie +12 more
openaire +3 more sources