Results 1 to 10 of about 127,375 (121)

P-I snake venom metalloproteinase is able to activate the complement system by direct cleavage of central components of the cascade. [PDF]

PLoS Neglected Tropical Diseases, 2013
BACKGROUND: Snake Venom Metalloproteinases (SVMPs) are amongst the key enzymes that contribute to the high toxicity of snake venom. We have recently shown that snake venoms from the Bothrops genus activate the Complement system (C) by promoting direct ...
Giselle Pidde-Queiroz, Fábio Carlos Magnoli, Fernanda C V Portaro, Solange M T Serrano, Aline Soriano Lopes, Adriana Franco Paes Leme, Carmen W van den Berg, Denise V Tambourgi   +7 more
doaj   +4 more sources

Inhibition of a Snake Venom Metalloproteinase by the Flavonoid Myricetin

Molecules, 2018
Most of the snakebite envenomations in Central and South America are caused by species belonging to Bothrops genus. Their venom is composed mainly by zinc-dependent metalloproteinases, responsible of the hemorrhage characteristic of these envenomations ...
Jaime Andres Pereañez, Lina Preciado, Rey-Suárez P   +2 more
exaly   +3 more sources

Qualitative Analysis of Proteins in Two Snake Venoms, Gloydius Blomhoffii and Agkistrodon Acutus

Journal of Pharmacopuncture, 2022
Objectives: Snake venom is a complex mixture of various pharmacologically active substances, such as small proteins, peptides, and organic and mineral components.
Su-Jeong Ha, Yeo-Ok Choi, Eun-Bin Kwag, Soo-Dam Kim, Hwa-seung Yoo, In-Cheol Kang, So-Jung Park   +6 more
doaj   +1 more source

Antiprotozoal Effect of Snake Venoms and Their Fractions: A Systematic Review

Pathogens, 2021
Background: Protozoal infection is a lingering public health issue of great concern, despite efforts to produce drugs and vaccines against it. Recent breakthrough research has discovered alternative antiprotozoal agents encompassing the use of snake ...
Zainab U. Abdullahi, Salihu S. Musa, Daihai He, Umar M. Bello   +3 more
doaj   +1 more source

Venom-gland transcriptomics of the Malayan pit viper (Calloselasma rhodostoma) for identification, classification, and characterization of venom proteins

Heliyon, 2023
The Malayan pit viper (Calloselasma rhodostoma) is a hemotoxic snake widely found in Southeast Asia and is responsible for the majority of poisoning cases in this region, including Thailand. However, a comprehensive knowledge of the venom protein profile
Poom Adisakwattana, Lawan Chanhome, Narongsak Chaiyabutr, Orawan Phuphisut, Onrapak Reamtong, Charin Thawornkuno   +5 more
doaj   +1 more source

Structure-Function Relationship of the Disintegrin Family: Sequence Signature and Integrin Interaction

Frontiers in Molecular Biosciences, 2021
Disintegrins are small cysteine-rich proteins found in a variety of snake venom. These proteins selectively modulate integrin function, heterodimeric receptors involved in cell-cell and cell-matrix interaction that are widely studied as therapeutic ...
Ariana A. Vasconcelos, Ariana A. Vasconcelos, Jorge C. Estrada, Victor David, Luciana S. Wermelinger, Fabio C. L. Almeida, Fabio C. L. Almeida, Russolina B. Zingali   +7 more
doaj   +1 more source

Venom Variation of Neonate and Adult Chinese Cobras in Captivity Concerning Their Foraging Strategies

Toxins, 2022
The venom and transcriptome profile of the captive Chinese cobra (Naja atra) is not characterized  until now. Here, LC-MS/MS and illumine technology were used to unveil the venom and trascriptome of neonates and adults N. atra specimens.
Xuekui Nie, Qianzi Chen, Chen Wang, Wangxiang Huang, Ren Lai, Qiumin Lu, Qiyi He, Xiaodong Yu   +7 more
doaj   +1 more source

De Novo Venom Gland Transcriptome Assembly and Characterization for Calloselasma rhodostoma (Kuhl, 1824), the Malayan Pit Viper from Malaysia: Unravelling Toxin Gene Diversity in a Medically Important Basal Crotaline

Toxins, 2023
In Southeast Asia, the Malayan Pit Viper (Calloselasma rhodostoma) is a venomous snake species of medical importance and bioprospecting potential. To unveil the diversity of its toxin genes, this study de novo assembled and analyzed the venom gland ...
Choo Hock Tan, Kae Yi Tan, Tzu Shan Ng, Nget Hong Tan, Ho Phin Chong   +4 more
doaj   +1 more source

A transcriptomic view of the proteome variability of newborn and adult Bothrops jararaca snake venoms. [PDF]

PLoS Neglected Tropical Diseases, 2012
BACKGROUND: Snake bite is a neglected public health problem in communities in rural areas of several countries. Bothrops jararaca causes many snake bites in Brazil and previous studies have demonstrated that the pharmacological activities displayed by ...
André Zelanis, Débora Andrade-Silva, Marisa M Rocha, Maria F Furtado, Solange M T Serrano, Inácio L M Junqueira-de-Azevedo, Paulo Lee Ho   +6 more
doaj   +1 more source

Biochemistry and toxicology of proteins and peptides purified from the venom of Vipera berus berus

Toxicon: X, 2022
The isolation and characterization of individual snake venom components is important for a deeper understanding of the pathophysiology of envenomation and for improving the therapeutic procedures of patients. It also opens possibilities for the discovery
Jüri Siigur, PhD, Ene Siigur, PhD
doaj   +1 more source