Results 1 to 10 of about 70 (67)
Metalloproteases and tendinopathy [PDF]
Muscle Ligaments and Tendons Journal, 2013 Matrix metalloproteinases (MMP) are involved in the development of tendinopathy. These potent enzymes completely degrade all components of the connective tissue, modify the extracellular matrix (ECM), and mediate the development of painful tendinopathy.
Del Buono A +3 more
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Hyalectanase Activities by the ADAMTS Metalloproteases [PDF]
International Journal of Molecular Sciences, 2021 The hyalectan family is composed of the proteoglycans aggrecan, versican, brevican and neurocan. Hyalectans, also known as lecticans, are components of the extracellular matrix of different tissues and play essential roles in key biological processes including skeletal development, and they are related to the correct maintenance of the vascular and ...
Fontanil López, Tania +5 more
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Current Protocols in Protein Science, 2001 AbstractMetalloproteases (metallopeptidases) are composed of a diverse group of endopeptidases and exopeptidases. Because metalloproteases play key roles in many normal biological processes, their aberrant activities have been implicated in diseases such as arthritis, cancer, cardiovascular diseases, nephritis, disorders in the central nervous system ...
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Families of zinc metalloproteases [PDF]
FEBS Letters, 1994 A scheme based on the zinc binding site [1992, FEBS Lett. 312, 110–114] has been extended to classify zinc metalloproteases into distinct families. The gluzincins, defined by the HEXXH motif and a glutamic acid as the third zinc ligand, include the thermolysin, endopeptidase‐24.11, aminopeptidase, angiotensin converting enzyme, endopeptidase‐24.15, and
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Metalloproteases of the Inner Mitochondrial Membrane [PDF]
Biochemistry, 2017 The inner mitochondrial membrane (IM) is among the most protein-rich cellular compartments. The metastable IM subproteome where the concentration of proteins is approaching oversaturation creates a challenging protein folding environment with a high probability of protein malfunction or aggregation.
Roman M. Levytskyy +2 more
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Matrix metalloproteases and PAR1 activation [PDF]
Blood, 2013 AbstractCardiovascular diseases, including atherothrombosis, are the leading cause of morbidity and mortality in the United States, Europe, and the developed world. Matrix metalloproteases (MMPs) have recently emerged as important mediators of platelet and endothelial function, and atherothrombotic disease.
Karyn M, Austin +2 more
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The molecular architecture of the metalloprotease FtsH [PDF]
Proceedings of the National Academy of Sciences, 2006 The ATP-dependent integral membrane protease FtsH is universally conserved in bacteria. Orthologs exist in chloroplasts and mitochondria, where in humans the loss of a close FtsH-homolog causes a form of spastic paraplegia. FtsH plays a crucial role in quality control by degrading unneeded or damaged membrane proteins, but it also targets ...
Bieniossek C +5 more
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Metalloproteases and Adipogenesis: A Weighty Subject [PDF]
The American Journal of Pathology, 2002 Obesity has become a prevalent health hazard in industrialized countries and is closely associated with a number of pathological disorders such as cancer, cardiovascular disease, hypertension, and non-insulin-dependent diabetes. 1 Even with such serious health implications there is still a great deal to learn before we can fully understand the ...
Jennifer, Lilla +2 more
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Computational design of metalloproteases
Abstract Although significant progress has been made in creating de novo metalloenzymes that hydrolyze activated esters 1,2 , the energetically demanding cleavage of amide bonds has remained a major challenge for enzyme design: amide bonds are ...
Anqi Chen +17 more
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Historical perspective of matrix metalloproteases
Frontiers in Bioscience, 2015 Matrix metalloproteinases (MMPs) were identified as early as 1962. Since this seminal finding, this family of zinc-dependent endopeptidases has been studied extensively. This collective work has resulted in delineation of MMP gene and protein structures, the mechanisms of control of MMPs, the action of MMPs on both extracellular matrices and other ...
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