Results 1 to 10 of about 32,111 (260)
Matrix Metalloproteases in Pancreatic Ductal Adenocarcinoma: Key Drivers of Disease Progression? [PDF]
Biology, 2020 Pancreatic cancer is a dismal disorder that is histologically characterized by a dense fibrotic stroma around the tumor cells. As the extracellular matrix comprises the bulk of the stroma, matrix degrading proteases may play an important role in ...
C A Spek +2 more
exaly +4 more sources
Tissue Inhibitor of Metalloproteases 3 (TIMP-3): In Vivo Analysis Underpins Its Role as a Master Regulator of Ectodomain Shedding [PDF]
Membranes, 2022 The proteolytical cleavage of transmembrane proteins with subsequent release of their extracellular domain, so-called ectodomain shedding, is a post-translational modification that plays an essential role in several biological processes, such as cell ...
Donatella Pia Spanò +1 more
exaly +4 more sources
Complex Evaluation of Tissue Factors in Pediatric Cholesteatoma
Children, 2021 The aim of this study was to describe the appearance and distribution of tissue remodeling markers (MMP-2, MMP-9, TIMP-2, TIMP-4), Sonic hedgehog gene protein (Shh), pro- and anti-inflammatory cytokines (IL–1, IL–10), transcription factor (NF-κβ ...
Kristaps Dambergs +2 more
doaj +1 more source
Inorganics, 2021 Development of catalysts for the selective hydrolysis of proteins is challenging, yet important for many applications in biotechnology and proteomics.
Nada D. Savić +3 more
doaj +1 more source
Toxins, 2023 Bitis arietans is a medically important snake found in Sub-Saharan Africa. The envenomation is characterized by local and systemic effects, and the lack of antivenoms aggravates the treatment.
Kemily Stephanie de Godoi +4 more
doaj +1 more source
Morphopathogenesis of Adult Acquired Cholesteatoma
Medicina, 2023 Background and Objectives. The aim of this study was to compare the distribution of proliferation markers (Ki-67, NF-κβ), tissue-remodeling factors (MMP-2, MMP-9, TIMP-2, TIMP-4), vascular endothelial growth factor (VEGF), interleukins (IL-1 and IL-10 ...
Kristaps Dambergs +2 more
doaj +1 more source
Hyalectanase Activities by the ADAMTS Metalloproteases [PDF]
International Journal of Molecular Sciences, 2021 The hyalectan family is composed of the proteoglycans aggrecan, versican, brevican and neurocan. Hyalectans, also known as lecticans, are components of the extracellular matrix of different tissues and play essential roles in key biological processes including skeletal development, and they are related to the correct maintenance of the vascular and ...
Fontanil López, Tania +5 more
openaire +3 more sources
Viruses, 2023 Proprotein convertases activate various envelope glycoproteins and participate in cellular entry of many viruses. We recently showed that the convertase furin is critical for the infectivity of SARS-CoV-2, which requires cleavage of its spike protein (S)
Rachid Essalmani +8 more
doaj +1 more source
Metalloproteases and tendinopathy [PDF]
Muscle Ligaments and Tendons Journal, 2013 Matrix metalloproteinases (MMP) are involved in the development of tendinopathy. These potent enzymes completely degrade all components of the connective tissue, modify the extracellular matrix (ECM), and mediate the development of painful tendinopathy.
Del Buono A +3 more
openaire +6 more sources
Biomolecules, 2023 The aim of the present work was to evaluate if the use of grape pomace (GP) in the feeding of dairy ewes can improve the content of phenolic compounds (PCs) in the milk and affect the anti-inflammatory and antioxidative status of the milk.
Francesca Bennato +6 more
doaj +1 more source