Results 31 to 40 of about 32,111 (260)
Zinc binding and chelating compounds as inhibitors of bacterial metalloproteases and human matrix metalloproteases [PDF]
, 2023 Bacterial multi-drug resistance is a major health problem worldwide. Inhibition of bacterial virulence is suggested to be a promising strategy in the development of new antibacterial drugs.
Rahman, Fatema Amatur
core
Chilo iridescent virus encodes two functional metalloproteases [PDF]
, 2019 The genome of Chilo iridescent virus (CIV) has two open reading frames (ORFs) with matrix metalloprotease (MMP) domains. The protein encoded by ORF 136R contains 178 amino acids with over 40% amino acid sequence identity to hypothetical metalloproteases ...
Nalcacioglu, Remziye +3 more
core +3 more sources
Endocrines, 2023 Prostate cancer represents the most common type of cancer among males and the second leading cause of cancer death in men in Western society. In most cases (~70%), PC has a slow and symptom-free growth, whereas it is more aggressive in the remaining ...
Carmela Sorrentino +7 more
doaj +1 more source
Toxins, 2019 Human accidents with spiders of the genus Loxosceles are an important health problem affecting thousands of people worldwide. Patients evolve to severe local injuries and, in many cases, to systemic disturbances as acute renal failure, in which cases ...
Paula A. L. Calabria +6 more
doaj +1 more source
Targeting ADAM10 in Cancer and Autoimmunity
Frontiers in Immunology, 2020 Generating inhibitors for ADisintegrin And Metalloproteinase 10 (ADAM10), a zinc-dependent protease, was heavily invested in by the pharmaceutical industry starting over 20 years ago. There has been much enthusiasm in basic research for these inhibitors,
Timothy M. Smith +2 more
doaj +1 more source
Journal of Venomous Animals and Toxins including Tropical Diseases, 2007 Two fibrinogenolytic enzymes, Bothrops alternatus metalloprotease isoform (BaltMP)-I and II, were purified from Bothrops alternatus venom using Diethylaminoethyl (DEAE) Sephacel, Sephadex G-75 and Heparin-Agarose column chromatography.
J. O. Costa +6 more
doaj +1 more source
Two poles of the anti-inflammatory action of azithromycin
Лечащий Врач, 2023 A breakthrough in the treatment of infectious diseases occurred with the advent of the era of antibiotics. Epidemiological studies on intracellular pathogens such as mycoplasmas, chlamydia, campylobacter and legionella in the 20th century served as an ...
E. N. Lazareva +2 more
doaj +1 more source
eLife, 2016 Metzincin metalloproteases have major roles in intercellular communication by modulating the function of membrane proteins. One of the proteases is the a-disintegrin-and-metalloprotease 10 (ADAM10) which acts as alpha-secretase of the Alzheimer's disease
Peer-Hendrik Kuhn +14 more
doaj +1 more source
Biomolecules, 2020 Atopic dermatitis (AD) is a protease-modulated chronic disorder with heterogenous clinical manifestations which may lead to an imprecise diagnosis. To date, there are no diagnostic protease tests for AD.
Fernando Valenzuela +6 more
doaj +1 more source
Biomedicines, 2020 Fetal undernutrition programs hypertension and cardiovascular diseases, and resistance artery remodeling may be a contributing factor. We aimed to assess if fetal undernutrition induces resistance artery remodeling and the relationship with hypertension.
Perla Y. Gutiérrez-Arzapalo +7 more
doaj +1 more source