Results 41 to 50 of about 24,294 (246)

The Androgen Regulation of Matrix Metalloproteases in Prostate Cancer and Its Related Tumor Microenvironment

Endocrines, 2023
Prostate cancer represents the most common type of cancer among males and the second leading cause of cancer death in men in Western society. In most cases (~70%), PC has a slow and symptom-free growth, whereas it is more aggressive in the remaining ...
Carmela Sorrentino, Rosa D’Angiolo, Giulia Gentile, Pia Giovannelli, Bruno Perillo, Antimo Migliaccio, Gabriella Castoria, Marzia Di Donato   +7 more
doaj   +1 more source

Purification and functional characterization of two fibrinogenolytic enzymes from Bothrops alternatus venom

Journal of Venomous Animals and Toxins including Tropical Diseases, 2007
Two fibrinogenolytic enzymes, Bothrops alternatus metalloprotease isoform (BaltMP)-I and II, were purified from Bothrops alternatus venom using Diethylaminoethyl (DEAE) Sephacel, Sephadex G-75 and Heparin-Agarose column chromatography.
J. O. Costa, C. B. Petric, A. Hamaguchi, M. I. Homsi-Brandeburgo, C. Z. Oliveira, A. M. Soares, F. Oliveira   +6 more
doaj   +1 more source

Invasion of the central nervous system by Cryptococcus neoformans requires a secreted fungal metalloprotease. [PDF]

, 2014
UnlabelledCryptococcus spp. cause life-threatening fungal infection of the central nervous system (CNS), predominantly in patients with a compromised immune system.
Bautos, Jennifer M, Gelli, Angie, Jamklang, Mantana, Na Pombejra, Sarisa, Tham, Rick, Thompson, George R, Uhrig, John P, Vu, Kiem   +7 more
core   +2 more sources

Systematic substrate identification indicates a central role for the metalloprotease ADAM10 in axon targeting and synapse function

eLife, 2016
Metzincin metalloproteases have major roles in intercellular communication by modulating the function of membrane proteins. One of the proteases is the a-disintegrin-and-metalloprotease 10 (ADAM10) which acts as alpha-secretase of the Alzheimer's disease
Peer-Hendrik Kuhn, Alessio Vittorio Colombo, Benjamin Schusser, Daniela Dreymueller, Sebastian Wetzel, Ute Schepers, Julia Herber, Andreas Ludwig, Elisabeth Kremmer, Dirk Montag, Ulrike Müller, Michaela Schweizer, Paul Saftig, Stefan Bräse, Stefan F Lichtenthaler   +14 more
doaj   +1 more source

Two poles of the anti-inflammatory action of azithromycin

Лечащий Врач, 2023
A breakthrough in the treatment of infectious diseases occurred with the advent of the era of antibiotics. Epidemiological studies on intracellular pathogens such as mycoplasmas, chlamydia, campylobacter and legionella in the 20th century served as an ...
E. N. Lazareva, Zh. B. Ponezheva, Yu. V. Kuznetsova   +2 more
doaj   +1 more source

SerpinB3 promotes pro-fibrogenic responses in activated hepatic stellate cells [PDF]

, 2017
SerpinB3 is a hypoxia- and hypoxia-inducible factor-2\u3b1-dependent cystein protease inhibitor that is up-regulated in hepatocellular carcinoma and in parenchymal cells during chronic liver diseases (CLD). SerpinB3 up-regulation in CLD patients has been
Albano, Emanuele, Biasiolo, Alessandra, Bocca, Claudia, Busletta, Chiara, Cannito, Stefania, David, Ezio, Miglietta, Antonella, Morello, Elisabetta, Novo, Erica, Parola, Maurizio, Paternostro, Claudia, Plebani, Mario, Pontisso, Patrizia, Quarta, Santina, Sutti, Salvatore, Turato, Cristian, Villano, Gianmarco   +16 more
core   +3 more sources

Gingival Crevicular Fluid Zinc- and Aspartyl-Binding Protease Profile of Individuals with Moderate/Severe Atopic Dermatitis

Biomolecules, 2020
Atopic dermatitis (AD) is a protease-modulated chronic disorder with heterogenous clinical manifestations which may lead to an imprecise diagnosis. To date, there are no diagnostic protease tests for AD.
Fernando Valenzuela, Javier Fernández, Marcela Aroca, Constanza Jiménez, Daniela Albers, Marcela Hernández, Alejandra Fernández   +6 more
doaj   +1 more source

The n-acetyl phenylalanine glucosamine derivative attenuates the inflammatory/catabolic environment in a chondrocyte-synoviocyte co-culture system [PDF]

, 2019
Osteoarthritis (OA), the most prevalent degenerative joint disease, still lacks a true disease-modifying therapy. The involvement of the NF-κB pathway and its upstream activating kinases in OA pathogenesis has been recognized for many years.
Borzi, R. M., Fini, M., Minguzzi, M., Pagani, S., Santi, S., Scotto D'Abusco, A., Sicuro, L., Veronesi, F.   +7 more
core   +1 more source

Fetal Undernutrition Induces Resistance Artery Remodeling and Stiffness in Male and Female Rats Independent of Hypertension

Biomedicines, 2020
Fetal undernutrition programs hypertension and cardiovascular diseases, and resistance artery remodeling may be a contributing factor. We aimed to assess if fetal undernutrition induces resistance artery remodeling and the relationship with hypertension.
Perla Y. Gutiérrez-Arzapalo, Pilar Rodríguez-Rodríguez, David Ramiro-Cortijo, Marta Gil-Ortega, Beatriz Somoza, Ángel Luis López de Pablo, Maria del Carmen González, Silvia M. Arribas   +7 more
doaj   +1 more source

Oxidative and Fibrinolytic Mechanisms: Two Important Processes to Consider in Platelet Storage

Turkish Journal of Hematology, 2023
Objective: Platelet-rich plasma (PRP) is used in multiple coagulation disorders. Its therapeutic effectiveness relies on technical procedures related to PRP procurement and preservation because free radicals induce platelet activation and aging.
Jesus Javier Garcia-Bañuelos, Marina Galicia-Moreno, Hugo Christian Monroy-Ramírez, Jose Navarro-Partıda, Blanca Estela Bastidas Ramirez, Arturo Santos, Juan Armendariz-Borunda   +6 more
doaj   +1 more source