Results 21 to 30 of about 32,111 (260)

Immunomodulatory role of metalloproteases in cancers: Current progress and future trends

Frontiers in Immunology, 2022
Metalloproteinases (MPs) is a large family of proteinases with metal ions in their active centers. According to the different domains metalloproteinases can be divided into a variety of subtypes mainly including Matrix Metalloproteinases (MMPs), A ...
Qi Wang, Kai Wang, Xiaojing Tan, Zhenxiang Li, Haiyong Wang   +4 more
doaj   +1 more source

Circulating TREM2 as a noninvasive diagnostic biomarker for NASH in patients with elevated liver stiffness

Hepatology, EarlyView., 2022
Abstract Background and Aims Reliable noninvasive biomarkers are an unmet clinical need for the diagnosis of NASH. This study investigates the diagnostic accuracy of the circulating triggering receptor expressed on myeloid cells 2 (plasma TREM2) as a biomarker for NASH in patients with NAFLD and elevated liver stiffness.
Vineesh Indira Chandran, Charlotte Wilhelmina Wernberg, Mette Munk Lauridsen, Maria Kløjgaard Skytthe, Sofie Marchsteiner Bendixen, Frederik Tibert Larsen, Camilla Dalby Hansen, Lea Ladegaard Grønkjær, Majken Storm Siersbæk, Tina Di Caterino, Sönke Detlefsen, Holger Jon Møller, Lars Grøntved, Kim Ravnskjaer, Søren Kragh Moestrup, Maja Sofie Thiele, Aleksander Krag, Jonas Heilskov Graversen   +17 more
wiley   +1 more source

Functional Mining of the Crotalus Spp. Venom Protease Repertoire Reveals Potential for Chronic Wound Therapeutics

Molecules, 2020
Chronic wounds are a major health problem that cause millions of dollars in expenses every year. Among all the treatments used, active wound treatments such as enzymatic treatments represent a cheaper and specific option with a fast growth category in ...
David Meléndez-Martínez, Luis Fernando Plenge-Tellechea, Ana Gatica-Colima, Martha Sandra Cruz-Pérez, José Manuel Aguilar-Yáñez, Cuauhtémoc Licona-Cassani   +5 more
doaj   +1 more source

MAPK inhibitors dynamically affect melanoma release of immune NKG2D-ligands, as soluble protein and extracellular vesicle-associated

Frontiers in Cell and Developmental Biology, 2023
Metastatic melanoma presents, in many cases, oncogenic mutations in BRAF, a MAPK involved in proliferation of tumour cells. BRAF inhibitors, used as therapy in patients with these mutations, often lead to tumour resistance and, thus, the use of MEK ...
Silvia López-Borrego, Carmen Campos-Silva, Amaia Sandúa, Tamara Camino, Lucía Téllez-Pérez, Estibaliz Alegre, Alexandra Beneitez, Ricardo Jara-Acevedo, Annette Paschen, María Pardo, Álvaro González, Mar Valés-Gómez   +11 more
doaj   +1 more source

Short communication: Natural molecules for the control of Paenibacillus larvae, causal agent of American foulbrood in honey bees (Apis mellifera L.)

Spanish Journal of Agricultural Research, 2019
Aim of study: To evaluate the potential bactericidal activity of natural molecules against Paenibacillus larvae. Moreover, we investigated if molecules that exhibit antimicrobial activity were able to inhibit the proteolytic activity of the bacterium ...
Pablo Giménez-Martínez, Noelia Cugnata, Rosa M. Alonso-Salces, Daniela Arredondo, Karina Antunez, Rosana De Castro, Sandra R. Fuselli   +6 more
doaj   +1 more source

Remodeling Factors, Transcription Factors and Angiogenetic Factors in Cholesteatoma in Ontogenetic Aspect [PDF]

Iranian Journal of Otorhinolaryngology, 2022
Introduction:The main goal of our study was to describe the transcription factor (NF-κβ), angiogenetic factor (VEGF), and remodeling markers (MMP-9 and TIMP-4) of the cholesteatoma tissue compared to control skin tissue. There are still uncertainties how
Kristaps Dambergs, Gunta Sumeraga, Māra Pilmane   +2 more
doaj   +1 more source

Induction of Matrix Metalloproteinases in Chondrocytes by Interleukin IL-1β as an Osteoarthritis Model

Journal of Mathematical and Fundamental Sciences, 2019
Osteoarthritis (OA) is a chronic disease of the joints and bones due to trauma or other joint-related diseases (secondary). Synovial inflammation commonly causes disturbance in joint homeostasis, which is associated with OA.
Ervi Afifah, Tjandrawati Mozef, Ferry Sandra, Seila Arumwardana, Dwi Davidson Rihibiha, Hayatun Nufus, Rizal Rizal, Annisa Amalia, Indra Bachtiar, Harry Murti, Wahyu Widowati   +10 more
doaj   +1 more source

Identification of Novel Metalloproteases [PDF]

, 2023
Approximately thirty percent of identified proteins do not have a known function. In order to determine the function of these proteins, programs like the Biochemistry Authentic Scientific Inquiry Lab (BASIL) are utilized.
Romero, Sophia, Davis, Anna, Lim, Andrew
core  

GSK-3 Inhibition Modulates Metalloproteases in a Model of Lung Inflammation and Fibrosis

Frontiers in Molecular Biosciences, 2021
Idiopathic pulmonary fibrosis (IPF) is mainly characterized by aberrant extracellular matrix deposition, consequent to epithelial lung injury and myofibroblast activation, and inflammatory response.
Francesco Cinetto, Jessica Ceccato, Ilaria Caputo, Daniela Cangiano, Barbara Montini, Francesca Lunardi, Maria Piazza, Carlo Agostini, Fiorella Calabrese, Gianpietro Semenzato, Marcello Rattazzi, Carmela Gurrieri, Riccardo Scarpa, Carla Felice, Fabrizio Vianello   +14 more
doaj   +1 more source

Synaptic Autoregulation by Metalloproteases and γ-Secretase [PDF]

, 2011
The proteolytic machinery comprising metalloproteases and γ-secretase, an intramembrane aspartyl protease involved in Alzheimer's disease, cleaves several substrates in addition to the extensively studied amyloid precursor protein.
Sophie Restituito, Khatri, L., Liu, X., Ipe Ninan, Weinberg, R. J., Latika Khatri, Mathews, P. M., Edward B. Ziff, Ziff, E. B., Ninan, I., Paul M. Mathews, Richard J. Weinberg, Xin Liu, Restituito, S.   +13 more
core   +2 more sources