Results 11 to 20 of about 24,294 (246)

Complex Evaluation of Tissue Factors in Pediatric Cholesteatoma

Children, 2021
The aim of this study was to describe the appearance and distribution of tissue remodeling markers (MMP-2, MMP-9, TIMP-2, TIMP-4), Sonic hedgehog gene protein (Shh), pro- and anti-inflammatory cytokines (IL–1, IL–10), transcription factor (NF-κβ ...
Kristaps Dambergs, Gunta Sumeraga, Māra Pilmane   +2 more
doaj   +1 more source

Broadening the Scope of Polyoxometalates as Artificial Proteases in Surfactant Solutions: Hydrolysis of Ovalbumin by Zr(IV)-Substituted Keggin Complex

Inorganics, 2021
Development of catalysts for the selective hydrolysis of proteins is challenging, yet important for many applications in biotechnology and proteomics.
Nada D. Savić, David E. Salazar Marcano, Thomas Quanten, Tatjana N. Parac-Vogt   +3 more
doaj   +1 more source

Anti-Metalloproteases: Production and Characterization of Polyclonal IgG Anti-F2 Fraction Antibodies Purified from the Venom of the Snake Bitis arietans

Toxins, 2023
Bitis arietans is a medically important snake found in Sub-Saharan Africa. The envenomation is characterized by local and systemic effects, and the lack of antivenoms aggravates the treatment.
Kemily Stephanie de Godoi, Felipe Raimondi Guidolin, Fernanda Calheta Vieira Portaro, Patrick Jack Spencer, Wilmar Dias da Silva   +4 more
doaj   +1 more source

Identification of a novel zinc metalloprotease through a global analysis of clostridium difficile extracellular proteins [PDF]

, 2013
Clostridium difficile is a major cause of infectious diarrhea worldwide. Although the cell surface proteins are recognized to be important in clostridial pathogenesis, biological functions of only a few are known.
A Barketi-Klai, A Bateman, A Boetzkes, A Dhalluin, A Molla, A Tasteyre, A Tasteyre, A Tasteyre, A Wright, A Wright, AJ Waligora, B Singh, BR Hoffmann, C Janoir, C Schwan, CB Reynolds, CC Häse, CM Surawicz, D Lyras, D Zhang, Davide Serruto, DC Nelson, DE Voth, DJ Rigden, E Calabi, E Calabi, EJ Kuipers, F Tonello, FH Niesen, Francesca Cantini, G Bensi, GA Dalkas, GM Slynn, H Maeda, I Poilane, Jeffrey T. Rubino, JM Kirby, JR O'Connor, JW Teo, K Mukherjee, K Yokoyama, KR Klimpel, L de la Riva, L Tulli, LG Pacheco, M Cerquetti, M Desvaux, M Miura, M Monot, M Rupnik, M Sebaihia, M Warny, MA Breidenbach, Manuele Martinelli, Maria Scarselli, Massimiliano Biagini, Meera Unnikrishnan, Mikael Skurnik, MJ Rodríguez-Ortega, N Sengupta, Nathalie Norais, NM Hooper, NS Duesbery, O Schneewind, Rosanna Leuzzi, RP Fagan, S Péchiné, S Péchiné, S Ravipaty, SA Kuehne, T Karasawa, T Karjalainen, TC Dingle, Valeria Cafardi   +73 more
core   +12 more sources

Morphopathogenesis of Adult Acquired Cholesteatoma

Medicina, 2023
Background and Objectives. The aim of this study was to compare the distribution of proliferation markers (Ki-67, NF-κβ), tissue-remodeling factors (MMP-2, MMP-9, TIMP-2, TIMP-4), vascular endothelial growth factor (VEGF), interleukins (IL-1 and IL-10 ...
Kristaps Dambergs, Gunta Sumeraga, Māra Pilmane   +2 more
doaj   +1 more source

SKI-1/S1P Facilitates SARS-CoV-2 Spike Induced Cell-to-Cell Fusion via Activation of SREBP-2 and Metalloproteases, Whereas PCSK9 Enhances the Degradation of ACE2

Viruses, 2023
Proprotein convertases activate various envelope glycoproteins and participate in cellular entry of many viruses. We recently showed that the convertase furin is critical for the infectivity of SARS-CoV-2, which requires cleavage of its spike protein (S)
Rachid Essalmani, Ursula Andréo, Alexandra Evagelidis, Maïlys Le Dévéhat, Oscar Henrique Pereira Ramos, Carole Fruchart Gaillard, Delia Susan-Resiga, Éric A. Cohen, Nabil G. Seidah   +8 more
doaj   +1 more source

Repurposing cancer drugs, batimastat and marimastat, to inhibit the activity of a group I metalloprotease from the venom of the Western Diamondback rattlesnake, Crotalus atrox [PDF]

, 2020
Snakebite envenomation causes over 140,000 deaths every year predominantly in developing countries. As a result, it is one of the most lethal neglected tropical diseases.
Bicknell, Andrew B., Lakshminarayanan, Karthik, Layfield, Harry J., Mehmi, Amita, Patel, Ketan, Ravishankar, Divyashree, Salim, Anika, Sonavane, Medha, Trim, Steven A., Vaiyapuri, Rajendran, Vaiyapuri, Sakthivel, Vallance, Thomas M., Williams, Harry F.   +12 more
core   +1 more source

Characterization of Phenolic Profile in Milk Obtained by Ewes Fed Grape Pomace: Reflection on Antioxidant and Anti-Inflammatory Status

Biomolecules, 2023
The aim of the present work was to evaluate if the use of grape pomace (GP) in the feeding of dairy ewes can improve the content of phenolic compounds (PCs) in the milk and affect the anti-inflammatory and antioxidative status of the milk.
Francesca Bennato, Andrea Ianni, Eleonora Oliva, Nicola Franceschini, Lisa Grotta, Manuel Sergi, Giuseppe Martino   +6 more
doaj   +1 more source

Age-dependent changes on fractalkine forms and their contribution to neurodegenerative diseases

Frontiers in Molecular Neuroscience, 2023
The chemokine fractalkine (FKN, CX3CL1), a member of the CX3C subfamily, contributes to neuron–glia interaction and the regulation of microglial cell activation.
Jaime Eugenín, Laura Eugenín-von Bernhardi, Rommy von Bernhardi   +2 more
doaj   +1 more source

Dipeptidyl Peptidase IV as a Muscle Myokine

Frontiers in Physiology, 2020
Dipeptidyl peptidase IV (DPP-IV) is a unique serine protease that exists in a membrane bound state and in a soluble state in most tissues in the body.
Heidi A. Kluess
doaj   +1 more source