Results 11 to 20 of about 32,111 (260)
Current Protocols in Protein Science, 2001 AbstractMetalloproteases (metallopeptidases) are composed of a diverse group of endopeptidases and exopeptidases. Because metalloproteases play key roles in many normal biological processes, their aberrant activities have been implicated in diseases such as arthritis, cancer, cardiovascular diseases, nephritis, disorders in the central nervous system ...
Nagase, H +2 more
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Families of zinc metalloproteases [PDF]
FEBS Letters, 1994 A scheme based on the zinc binding site [1992, FEBS Lett. 312, 110–114] has been extended to classify zinc metalloproteases into distinct families. The gluzincins, defined by the HEXXH motif and a glutamic acid as the third zinc ligand, include the thermolysin, endopeptidase‐24.11, aminopeptidase, angiotensin converting enzyme, endopeptidase‐24.15, and
Hooper, Nigel M., Nigel M. Hooper
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Neuron, 2003 Two families of metalloproteases, the matrix metalloproteases (MMPs) and the A Disintegrin and Metalloproteases (ADAMs), have recently been implicated in the formation of neural connections in the developing central nervous system.
McFarlane, Sarah
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Zinc-Chelating Compounds as Inhibitors of Human and Bacterial Zinc Metalloproteases [PDF]
, 2021 Inhibition of bacterial virulence is believed to be a new treatment option for bacterial infections. In the present study, we tested dipicolylamine (DPA), tripicolylamine (TPA), tris pyridine ethylene diamine (TPED), pyridine and thiophene derivatives as
Pål Rongved +13 more
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Heterologous expression of the astacin protease meprin v in Pichia pastoris [PDF]
, 2022 S.35-45Meprins are zinc-dependent proteases of the metzincin superfamily of metalloproteases. The enzymes are extracellular multi-domain proteins which are stabilized by disulfide bridges, dimerization, and glycosylation.
Schlenzig, D., Schilling, S.
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Age-dependent changes on fractalkine forms and their contribution to neurodegenerative diseases
Frontiers in Molecular Neuroscience, 2023 The chemokine fractalkine (FKN, CX3CL1), a member of the CX3C subfamily, contributes to neuron–glia interaction and the regulation of microglial cell activation.
Jaime Eugenín +2 more
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Dipeptidyl Peptidase IV as a Muscle Myokine
Frontiers in Physiology, 2020 Dipeptidyl peptidase IV (DPP-IV) is a unique serine protease that exists in a membrane bound state and in a soluble state in most tissues in the body.
Heidi A. Kluess
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Toxins, 2021 Snake venom metalloproteinases (SVMP) are involved in local inflammatory reactions observed after snakebites. Based on domain composition, they are classified as PI (pro-domain + proteolytic domain), PII (PI + disintegrin-like domains), or PIII (PII ...
Bianca C. Zychar +6 more
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Activity-Dependent Photoaffinity Labeling of Metalloproteases [PDF]
, 2017 Metalloproteases, notably members of the matrix metalloprotease (MMP) and A Disintegrin And Metalloprotease (ADAM) families play crucial roles in tissue remodeling, the liberation of growth factors and cytokines from cell membranes (shedding) and cell ...
Bischoff, Rainer +7 more
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Selective Hydrolysis of Transferrin Promoted by Zr-Substituted Polyoxometalates
Molecules, 2020 The hydrolysis of the iron-binding blood plasma glycoprotein transferrin (Tf) has been examined at pH = 7.4 in the presence of a series of Zr-substituted polyoxometalates (Zr-POMs) including Keggin (Et2NH2)10[Zr(PW11O39)2]∙7H2O (Zr-K 1:2), (Et2NH2)8[{α ...
Laura S. Van Rompuy +3 more
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