Results 41 to 50 of about 32,635 (169)
Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 7, Page 1403-1426, July 2026.ABSTRACT Snakebite envenomation is a major public health concern, particularly in low‐ and middle‐income regions where access to safe and effective antivenoms is limited. Traditional antivenoms, derived from immunization with crude venom, often trigger adverse reactions and lack specificity against key venom components.
Hanan Maoz, Amir Elalouf
wiley +1 more source
Serum-based inhibition of pitviper venom by eastern indigo snakes (Drymarchon couperi)
Biology Open, 2019 When organisms possess chemical defenses, their predators may eventually evolve resistance to their toxins. Eastern indigo snakes (Drymarchon couperi; EIS) prey on pitvipers and are suspected to possess physiological resistance to their venom.
Scott M. Goetz +6 more
doaj +1 more source
Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health
The FEBS Journal, Volume 293, Issue 13, Page 3881-3898, July 2026.Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin +2 more
wiley +1 more source
Toxins, 2022 Many venomous animals express toxins that show extraordinary levels of variation both within and among species. In snakes, most studies of venom variation focus on front-fanged species in the families Viperidae and Elapidae, even though rear-fanged ...
Peter A. Cerda +5 more
doaj +1 more source
The Role of Endothelin‐1 in Autoimmune Diseases: Mechanistic Insights and Therapeutic Targets
iNew Medicine, Volume 2, Issue 2, June 2026.The Role of Endothelin‐1 in Autoimmune Diseases. NF‐κB: nuclear factor kappa‐B; MAPK: mitogen‐activated protein kinase; PI3K: phosphoinositide 3‐kinase; ROS: reactive oxygen species; CTGF: connective tissue growth factor; TGF‐β: transforming growth factor‐β.
Xun Gong +5 more
wiley +1 more source
Data in Brief, 2016 Initial association of platelets after vascular injury is mediated by glycoprotein (GP)Ib-IX-V binding to von Willebrand factor (vWf) immobilized on exposed collagens and eventually leads to thrombus formation.
Eladio Flores Sanchez +8 more
doaj +1 more source
Toxins, 2023 The cytotoxicity caused by snake venoms is a serious medical problem that greatly contributes to the morbidity observed in snakebite patients. The cytotoxic components found in snake venoms belong to a variety of toxin classes and may cause cytotoxic ...
Eric Wachtel +8 more
doaj +1 more source
VIEW, Volume 7, Issue 3, June 2026.Cancer‐associated fibroblasts exert intricate mechanisms in the progression and metastasis of renal cell carcinoma. Existing studies have validated the relevant mechanisms of three signaling pathways, which hold promising potential as novel therapeutic targets.
Ruiqiang Sun +4 more
wiley +1 more source
Inflammatory pathogenesis of snake venom metalloproteinase‐induced skin necrosis [PDF]
European Journal of Immunology, 2003 AbstractLocal tissue damage, characterized by edema, hemorrhage and necrosis, is a common consequence of envenoming by many vipers. We have investigated the contribution of inflammatory responses induced by the venom metalloproteinase jararhagin (isolated from Bothrops jararaca venom) in the development of these lesions.
Gavin David, Laing +4 more
openaire +2 more sources
Acta Crystallographica Section F, Volume 82, Issue 5, Page 150-159, May 2026.The crystal structure of an Asp49 phospholipase A2 from L. muta is reported, revealing a tetrameric assembly, catalytic conservation and a polarized electrostatic surface potentially linked to membrane targeting.Snake‐venom phospholipases A2 (PLA2s) are small, structurally conserved enzymes that contribute significantly to the pathophysiology of ...
Noelia Erika Neyra Chama +9 more
wiley +1 more source