Results 61 to 70 of about 34,979 (216)

Mechanisms underpinning the permanent muscle damage induced by snake venom metalloprotease [PDF]

, 2019
Snakebite is a major neglected tropical health issue that affects over 5 million people worldwide resulting in around 1.8 million envenomations and 100,000 deaths each year.
Bicknell, Andrew, Collins-Hooper, Henry, Layfield, Harry, Matsakas, Antonios, Mellows, Ben, Mitchell, Robert, Patel, Ketan, Salamah, Maryam, Sfyri, Peggy, Vaiyapuri, Raj, Vaiyapuri, Sakthi, Williams, Harry   +11 more
core   +3 more sources

Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health

The FEBS Journal, EarlyView.
Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin, Sumit Bhutada, Suneel S. Apte   +2 more
wiley   +1 more source

Data for a direct fibrinolytic metalloproteinase, barnettlysin-I from Bothrops barnetti (barnett,s pitviper) snake venom with anti-thrombotic effect

Data in Brief, 2016
Initial association of platelets after vascular injury is mediated by glycoprotein (GP)Ib-IX-V binding to von Willebrand factor (vWf) immobilized on exposed collagens and eventually leads to thrombus formation.
Eladio Flores Sanchez, Michael Richardson, Luiza Helena Gremski, Silvio Sanches Veiga, Armando Yarleque, Stephan Niland, Augusto Martins Lima, Maria Inácia Estevao-Costa, Johannes Andreas Eble   +8 more
doaj   +1 more source

The effect of a serum containing acetyl hexapeptide‐8, dipeptide diaminobutyroyl benzylamide diacetate and gluconolactone on skin biomarkers, wrinkles and skin texture: Ex vivo and clinical studies

International Journal of Cosmetic Science, EarlyView.
The novel serum demonstrates significant anti‐skin aging effects, effectively improving static and dynamic wrinkles and skin texture. Therefore, this formulation holds promise as a safe and effective product in the field of anti‐wrinkle skincare products.
Mingjie Zhu, Xiaofeng He, Zailing Zhu, Stephen Lynch, Hequn Wang, Xiaoyin Zhou, Yidong Tu, Andrew Steel, Kung Chi Hsu, Yueqing Niu, Anna Cho, Mutsue Hashimoto, Xi Yan, Maggie Su, Wenna Wang   +14 more
wiley   +1 more source

Anti-inflammatory activity of Blutaparon portulacoides ethanolic extract against the inflammatory reaction induced by Bothrops jararacussu venom and isolated myotoxins BthTX-I and II [PDF]

, 2009
This article reports the anti-inflammatory effect of Blutaparon portulacoides (B. portulacoides), specifically the ethanolic extract of its aerial parts, on the edema formation and leukocyte influx caused by Bothrops jararacussu (B.
BARBOSA, AM, COGO, JC, PEREIRA, IC, RIBEIRO, W, SALVADOR, MJ, SOARES, AM, ZAMUNER, SR   +6 more
core   +2 more sources

Crystal structure and functional characterization of an Asp49 phospholipase A2 from the bushmaster (Lachesis muta)

Acta Crystallographica Section F, Volume 82, Issue 5, Page 150-159, May 2026.
The crystal structure of an Asp49 phospholipase A2 from L. muta is reported, revealing a tetrameric assembly, catalytic conservation and a polarized electrostatic surface potentially linked to membrane targeting.Snake‐venom phospholipases A2 (PLA2s) are small, structurally conserved enzymes that contribute significantly to the pathophysiology of ...
Noelia Erika Neyra Chama, Frey Francisco Romero Vargas, Eloy Condori Mamani, Jhon Antoni Vargas, Adriano Alves Furtado, Humberto D'Muniz Pereira, Ronald Demetrio Navarro Oviedo, Richard Charles Garratt, José Luis Javier Vega Ramírez, Diego Antonio Leonardo   +9 more
wiley   +1 more source

Inflammatory pathogenesis of snake venom metalloproteinase‐induced skin necrosis [PDF]

European Journal of Immunology, 2003
AbstractLocal tissue damage, characterized by edema, hemorrhage and necrosis, is a common consequence of envenoming by many vipers. We have investigated the contribution of inflammatory responses induced by the venom metalloproteinase jararhagin (isolated from Bothrops jararaca venom) in the development of these lesions.
Gavin David, Laing, Patricia Bianca, Clissa, Robert David Geoffrey, Theakston, Ana Maria, Moura-da-Silva, Mark John, Taylor   +4 more
openaire   +2 more sources

Venoms of Rear-Fanged Snakes: New Proteins and Novel Activities

Frontiers in Ecology and Evolution, 2019
Snake venom research has focused on front-fanged venomous snakes because of the high incidence of human morbidity and mortality from envenomations and larger venom yields of these species, while venoms from rear-fanged snakes have been largely neglected.
Cassandra M. Modahl, Stephen P. Mackessy
doaj   +1 more source

High throughput screening and identification of coagulopathic snake venom proteins and peptides using nanofractionation and proteomics approaches.

PLoS Neglected Tropical Diseases, 2020
Snakebite is a neglected tropical disease that results in a variety of systemic and local pathologies in envenomed victims and is responsible for around 138,000 deaths every year.
Julien Slagboom, Marija Mladić, Chunfang Xie, Taline D Kazandjian, Freek Vonk, Govert W Somsen, Nicholas R Casewell, Jeroen Kool   +7 more
doaj   +1 more source

The Genetic Basis of Color Polymorphism in the Orb‐Web Spider Gasteracantha cancriformis

Ecology and Evolution, Volume 16, Issue 3, March 2026.
This study investigates the genetic basis of coloration in the polymorphic spider Gasteracantha cancriformis using RNA‐seq data from different female color morphs. We assembled a reference transcriptome and identified differentially expressed genes associated with known pigmentation pathways, including carotenoids, melanin, ommochromes, and pteridines.
Paula Torres‐Quintero, Carolina Pardo‐Díaz, Fabian Salgado‐Roa, Camilo Salazar   +3 more
wiley   +1 more source