Results 81 to 90 of about 127,375 (121)

Snake venom gland organoids [PDF]

, 2020
Wnt dependency and Lgr5 expression define multiple mammalian epithelial stem cell types. Under defined growth factor conditions, such adult stem cells (ASCs) grow as 3D organoids that recapitulate essential features of the pertinent epithelium.
Getreuer, W., Kool, J., Iglesias, C.L., Peters, P.J., Ineveld, R.L. van, Richardson, M.K., Bakker, M.A.G. de, Ainsworth, S., Korving, J., Post, Y., Wetering, W.J. van de, Heinz, M.C., Bar-Ephraim, Y.E., Beumer, J., Kerkkamp, H.M., Slagboom, J., Snippert, H.J.G., Rios, A.C., Vonk, F.J., Clevers, H., Kleef, R.G.D.M. van, Barbanson, B. de, Oudenaarden, A. van, Spijkers, X.M., Wevers, N.R., Kazandjian, T.D., Begthel, H., Casewell, N.R., Olivier, T., Westerink, R.H.S., Puschhof, J.   +29 more
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Transcriptome analysis of Deinagkistrodon acutus venomous gland focusing on cellular structure and functional aspects using expressed sequence tags

BMC Genomics, 2006
Background The snake venom gland is a specialized organ, which synthesizes and secretes the complex and abundant toxin proteins. Though gene expression in the snake venom gland has been extensively studied, the focus has been on the components of the ...
Qiu Pengxin, Luo Yingfeng, Huang Yijun, Zhang Xiaowei, Yin Wei, Liu Qinghua, Zhang Bing, Su Xingwen, Yu Jun, Hu Songnian, Yan Guangmei   +10 more
doaj   +1 more source

Inhibition of hemorragic snake venom components: old and new approaches.

, 2010
Snake venoms are complex toxin mixtures. Viperidae and Crotalidae venoms, which are hemotoxic, are responsible for most of the envenomations around the world.
RAVERA, SILVIA, CALZIA, DANIELA, PANFOLI, ISABELLA, MORELLI, ALESSANDRO   +3 more
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Clinical effectiveness of hymenoptera venom immunotherapy [PDF]

, 2013
Treatment failure during venom immunotherapy (VIT) may be associated with a variety of risk factors. Our aim was to evaluate the association of baseline serum tryptase concentration (BTC) and of other parameters with the frequency of VIT failure during ...
Scheipl, Fabian, Darsow, Ulf, Reider, Norbert, Bonifazi, Floriano, Aberer, Werner, Schmid-Grendelmeier, Peter, Ruëff, Franziska, Treudler, Regina, Biló, Maria Beatrice, Sturm, Gunter Johannes, Küchenhoff, Helmut, Severino, Maurizio, Wüthrich, Brunello, Seitz, Michael J., Quercia, Oliviero, Bodzenta-Lukaszyk, Anna, Lang, Roland, Haeberli, Gabrielle, Campi, Paolo, Hawranek, Thomas, Müller, Ulrich, Przybilla, Bernhard   +21 more
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Identification of antigenic proteins from the venom of Malaysian snakes using immunoprecipitation assay and tandem mass spectrometry (LC-MS/MS)

Heliyon
Snake envenomation poses a significant risk to Malaysians and country visitors. Malaysia witnesses an estimated 650 snake bites per 100,000 population annually.
Preetha Rajendiran, Rakesh Naidu, Iekhsan Othman, Syafiq Asnawi Zainal Abidin   +3 more
doaj   +1 more source

Inflammatory pathogenesis of snake venom metalloproteinase-induced skin necrosis

, 2003
Local tissue damage, characterized by edema, hemorrhage and necrosis, is a common consequence of envenoming by many vipers. We have investigated the contribution of inflammatory responses induced by the venom metalloproteinase jararhagin (isolated from ...
Clissa, Patricia Bianca, Theakston, Robert David Geoffrey, Taylor, Mark; id_orcid, Laing, Gavin David, Moura-da-Silva, Ana Maria   +4 more
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Role of carbohydrate chain of a thrombin-like protease isolated from the venom of Agkistrodon halys brevicaudus stejneger snake [PDF]

, 2011
Recently, we determined the primary structure of a thrombin-like protease isolated from the venom of Agkistrodon halys brevicaudus stejneger snake. The protease was found to be a single chain glycoprotein with a molecular weight of 32 kDa, containing 18%
村瀬, 豊, 齋藤, 健治, 竹田, 忠紘, 岡田, 忠, 山本, 親, 酒井, 淳一, 箭頭, 真理子, 中野, 貴博   +7 more
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Combination of Rhamnetin and RXP03 Mitigates Venom-Induced Toxicity in Murine Models: Preclinical Insights into Dual-Target Antivenom Therapy

Toxins
Snakebite is a significant global public health challenge, and the limited application of antivenom has driven the exploration of novel therapies. Combination therapy using small-molecule drugs targeting phospholipases A2 (PLA2) and metalloproteinases ...
Jianqi Zhao, Guangyao Liu, Xiao Shi, Chunhong Huang   +3 more
doaj   +1 more source

Snake Venom Metalloproteinases

, 2017
This special edition of Toxins will cover recent developments in snake venom metalloproteinase structure, function and clinical implications. It will include a historical retrospective of the discovery of Snake Venom Metalloproteinases (SVMPs) and early ...
José María Gutiérrez, Jay Fox
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Suramin inhibits the early effects of PLA(2) neurotoxins at mouse neuromuscular junctions: a twitch tension study [PDF]

, 2011
Several phospholipase A(2) (PLA(2)) neurotoxins from snake venoms can affect acetylcholine release at the neuromuscular junction. In isolated nerve-muscle preparations three distinct phases have been described for this phenomenon: An initial transient ...
Fathi, Behrooz, Rowan, Edward G, Harvey, Alan L   +2 more
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