Results 81 to 90 of about 32,635 (169)

Combination of Rhamnetin and RXP03 Mitigates Venom-Induced Toxicity in Murine Models: Preclinical Insights into Dual-Target Antivenom Therapy

Toxins
Snakebite is a significant global public health challenge, and the limited application of antivenom has driven the exploration of novel therapies. Combination therapy using small-molecule drugs targeting phospholipases A2 (PLA2) and metalloproteinases ...
Jianqi Zhao, Guangyao Liu, Xiao Shi, Chunhong Huang   +3 more
doaj   +1 more source

Isolation, characterization, and expression of the Montivipera raddei (Caucasus viper) venom metalloprotease-like protein

Research in Pharmaceutical Sciences
Background and purpose: Snake venom contains numerous proteolytic enzymes, including metalloproteases. This study aimed to isolate, characterize the metalloproteinase from Montivipera raddei venom and insert its cDNA into a host cell genome for ...
Zohreh Jafari, Behnam Sedaghati, Mohammad Kaboli, Bahram Kazemi, Mojgan Bandehpour   +4 more
doaj   +1 more source

Complement System Inhibition Modulates the Pro-Inflammatory Effects of a Snake Venom Metalloproteinase. [PDF]

Front Immunol, 2019
Luchini LSG, Pidde G, Squaiella-Baptistão CC, Tambourgi DV.   +3 more
europepmc   +1 more source

Corrigendum: Complement System Inhibition Modulates the Pro-Inflammatory Effects of a Snake Venom Metalloproteinase. [PDF]

Front Immunol, 2019
Luchini LSG, Pidde G, Squaiella-Baptistão CC, Tambourgi DV.   +3 more
europepmc   +1 more source

Potential of Matrix Metalloproteinase Inhibitors for the Treatment of Local Tissue Damage Induced by a Type P-I Snake Venom Metalloproteinase. [PDF]

Toxins (Basel), 2019
Preciado LM, Pereañez JA, Comer J.
europepmc   +1 more source

Interactions between Triterpenes and a P-I Type Snake Venom Metalloproteinase: Molecular Simulations and Experiments. [PDF]

Toxins (Basel), 2018
Preciado LM, Pereañez JA, Azhagiya Singam ER, Comer J.   +3 more
europepmc   +1 more source

Comprehensive Study of the Proteome and Transcriptome of the Venom of the Most Venomous European Viper: Discovery of a New Subclass of Ancestral Snake Venom Metalloproteinase Precursor-Derived Proteins. [PDF]

J Proteome Res, 2019
Leonardi A, Sajevic T, Pungerčar J, Križaj I.   +3 more
europepmc   +1 more source

Insights into the Mechanisms Involved in Strong Hemorrhage and Dermonecrosis Induced by Atroxlysin-Ia, a PI-Class Snake Venom Metalloproteinase. [PDF]

Toxins (Basel), 2017
Freitas-de-Sousa LA, Colombini M, Lopes-Ferreira M, Serrano SMT, Moura-da-Silva AM.   +4 more
europepmc   +1 more source

Data on global expression of non-coding RNome in mice gastrocnemius muscle exposed to jararhagin, snake venom metalloproteinase. [PDF]

Data Brief, 2016
Clissa PB, Pessôa R, Ferraz KF, de Souza DR, Sanabani SS.   +4 more
europepmc   +1 more source

Natural inhibitors of snake venom metalloproteinases

Natural inhibitors of snake venom metalloproteinases
Snakebites are a hazard in the tropical world. Although antivenom therapy is effective, it is beset with inherent drawbacks. A better understanding of the major components of snake venoms and their neutralisation will help in improving snakebite treatment.
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