Results 101 to 110 of about 34,979 (216)

Novel Catalytically-Inactive PII Metalloproteinases from a Viperid Snake Venom with Substitutions in the Canonical Zinc-Binding Motif

Toxins, 2016
Snake venom metalloproteinases (SVMPs) play key biological roles in prey immobilization and digestion. The majority of these activities depend on the hydrolysis of relevant protein substrates in the tissues.
Erika Camacho, Libia Sanz, Teresa Escalante, Alicia Pérez, Fabián Villalta, Bruno Lomonte, Ana Gisele C. Neves-Ferreira, Andrés Feoli, Juan J. Calvete, José María Gutiérrez, Alexandra Rucavado   +10 more
doaj   +1 more source

Serum Proteinogram in the Free‐Living Brazilian Common Opossum (Didelphis aurita)

ELECTROPHORESIS, Volume 46, Issue 18, Page 1447-1454, September 2025.
ABSTRACT Didelphis aurita is a synanthropic marsupial widely distributed in southeastern Brazil, known for its resistance to venom and its relevance in biomedical research. This study aimed to characterize the serum proteinogram of free‐living D. aurita individuals.
Andrés Mauricio Ortega Orozco, Lucas Drumond Bento, Pollyanna Cordeiro Souto, Fabrícia Modolo Girardi, Verônica Rodrigues Castro, João Vitor Gonçalves de Oliveira, Camilo José Ramirez Lopez, Edvaldo Barros, Artur Kanadani Campos, Leandro Abreu da Fonseca   +9 more
wiley   +1 more source

Transcriptome analysis of Deinagkistrodon acutus venomous gland focusing on cellular structure and functional aspects using expressed sequence tags

BMC Genomics, 2006
Background The snake venom gland is a specialized organ, which synthesizes and secretes the complex and abundant toxin proteins. Though gene expression in the snake venom gland has been extensively studied, the focus has been on the components of the ...
Qiu Pengxin, Luo Yingfeng, Huang Yijun, Zhang Xiaowei, Yin Wei, Liu Qinghua, Zhang Bing, Su Xingwen, Yu Jun, Hu Songnian, Yan Guangmei   +10 more
doaj   +1 more source

Molprint 2D-Based Identification and Synthesis of Novel Chromene Based Small Molecules that Target Pla2: Validation through Chemo-And Bioinformatics Approaches [PDF]

, 2016
Phospholipase A2 (PLA2) is known to regulate inflammation and hence it is considered as a validated drug-target by medicinal chemists. In this report, we have identified and considered a highly ranked ligand from the ZINC-drug-like compounds database ...
Basappa, N., Bender, A., Bharathkumar, H., Bulusu, K.C., Fuchs, J.E., Keerthy, H.K., Mervin, L.H., Priya, B.S., Rangappa, K.S., Rangappa, S., Swamy, A.S., Vivek, H.K.   +11 more
core   +1 more source

Quantum Chemical, Spectroscopic and In Silico (Molecular Docking, Molecular Dynamic and ADME) Studies on Anti‐Aging Pentapeptide‐3 (Vialox)

International Journal of Quantum Chemistry, Volume 125, Issue 15, August 5, 2025.
This study investigates the anti‐aging potential of Pentapeptide‐3 (Vialox) using quantum chemical, spectroscopic, and in silico methods. Molecular docking and dynamics analysis confirm its stable interactions with key aging‐related receptors, highlighting Pentapeptide‐3 as a promising candidate for cosmeceutical applications targeting skin aging ...
Dilan Akhan, Bilge Bicak, Serda Kecel Gunduz, Elif Akalin   +3 more
wiley   +1 more source

A proteomics and transcriptomics investigation of the venom from the Barychelid spider Trittame loki (brush-foot trapdoor) [PDF]

, 2013
Although known for their potent venom and ability to prey upon both invertebrate and vertebrate species, the Barychelidae spider family has been entirely neglected by toxinologists. In striking contrast, the sister family Theraphosidae (commonly known as
Agostino Antunes, Alun Jones, Bryan Fry, Conesa, Dolyce Low, Eivind Undheim, Glenn King, Goldman, Herzig, Kartik Sunagar, Laurence Kely, Nielsen, Nyoman Kurniawan, Posada, Syed Ali, Tim Ruder, Timothy Jackson, Volker Herzig   +17 more
core   +3 more sources

Snakebite drug discovery: high-throughput screening to identify novel snake venom metalloproteinase toxin inhibitors. [PDF]

Front Pharmacol, 2023
Clare RH, Dawson CA, Westhorpe A, Albulescu LO, Woodley CM, Mosallam N, Chong DJW, Kool J, Berry NG, O'Neill PM, Casewell NR.   +10 more
europepmc   +1 more source

Identification of antigenic proteins from the venom of Malaysian snakes using immunoprecipitation assay and tandem mass spectrometry (LC-MS/MS)

Heliyon
Snake envenomation poses a significant risk to Malaysians and country visitors. Malaysia witnesses an estimated 650 snake bites per 100,000 population annually.
Preetha Rajendiran, Rakesh Naidu, Iekhsan Othman, Syafiq Asnawi Zainal Abidin   +3 more
doaj   +1 more source

Transcriptome and venom proteome of the box jellyfish Chironex fleckeri [PDF]

, 2015
Background: The box jellyfish, Chironex fleckeri, is the largest and most dangerous cubozoan jellyfish to humans. It produces potent and rapid-acting venom and its sting causes severe localized and systemic effects that are potentially life-threatening ...
Brinkman, Diane L., Dash, Debasis, Jia, Xinying, Kumar, Dhirendra, Kvaskoff, David, Mulvenna, Jason, Potriquet, Jeremy   +6 more
core   +1 more source

Combination of Rhamnetin and RXP03 Mitigates Venom-Induced Toxicity in Murine Models: Preclinical Insights into Dual-Target Antivenom Therapy

Toxins
Snakebite is a significant global public health challenge, and the limited application of antivenom has driven the exploration of novel therapies. Combination therapy using small-molecule drugs targeting phospholipases A2 (PLA2) and metalloproteinases ...
Jianqi Zhao, Guangyao Liu, Xiao Shi, Chunhong Huang   +3 more
doaj   +1 more source