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Inflammatory effects of snake venom metalloproteinases [PDF]

open access: yesMemorias do Instituto Oswaldo Cruz, 2005
Metalloproteinases are abundant enzymes in crotaline and viperine snake venoms. They are relevant in the pathophysiology of envenomation, being responsible for local and systemic hemorrhage frequently observed in the victims.
Catarina de Fátima Pereira Teixeira   +3 more
doaj   +8 more sources

Processing of Snake Venom Metalloproteinases: Generation of Toxin Diversity and Enzyme Inactivation

open access: yesToxins, 2016
Snake venom metalloproteinases (SVMPs) are abundant in the venoms of vipers and rattlesnakes, playing important roles for the snake adaptation to different environments, and are related to most of the pathological effects of these venoms in human victims.
Richard H Valente   +1 more
exaly   +4 more sources

Understanding the Snake Venom Metalloproteinases: An Interview with Jay Fox and José María Gutiérrez

open access: yesToxins, 2017
Jay W. Fox and José María Gutiérrez recently finished editing a Special Issue on the topic “Snake Venom Metalloproteinases” in Toxins. The Special Issue covers a wide range of topics, including the molecular evolution and structure of snake venom ...
Jay W. Fox, José María Gutiérrez
doaj   +2 more sources

Proteomic Identification and Quantification of Snake Venom Biomarkers in Venom and Plasma Extracellular Vesicles

open access: yesToxins, 2021
The global exploration of snakebites requires the use of quantitative omics approaches to characterize snake venom as it enters into the systemic circulation.
Nicholas Kevin Willard   +11 more
doaj   +2 more sources

A Review of the Proteomic Profiling of African Viperidae and Elapidae Snake Venoms and Their Antivenom Neutralisation

open access: yesToxins, 2022
Snakebite envenoming is a neglected tropical disease (NTD) that results from the injection of snake venom of a venomous snake into animals and humans.
Benedict C. Offor   +2 more
doaj   +1 more source

Analysis of the Composition of Deinagkistrodon acutus Snake Venom Based on Proteomics, and Its Antithrombotic Activity and Toxicity Studies

open access: yesMolecules, 2022
There is a strong correlation between the composition of Deinagkistrodon acutus venom proteins and their potential pharmacological effects. The proteomic analysis revealed 103 proteins identified through label-free proteomics from 30 different snake ...
Jin Huang   +4 more
doaj   +1 more source

Proteomic insight into the venom composition of the largest European rear-fanged snake, Malpolon monspessulanus monspessulanus

open access: yesToxicon: X, 2022
Snake envenomations constitute a worldwide neglected tropical disease, with the vast majority of lethal bites inflicted by front-fanged snakes from the viperid and elapid groups.
Dominique Koua   +6 more
doaj   +1 more source

The Venom Composition of the Snake Tribe Philodryadini: ‘Omic’ Techniques Reveal Intergeneric Variability among South American Racers

open access: yesToxins, 2023
Snakes of the Philodryadini tribe are included in the Dipsadidae family, which is a diverse group of rear-fanged snakes widespread in different ecological conditions, including habitats and diet. However, little is known about the composition and effects
Emilly Campos Tioyama   +9 more
doaj   +1 more source

C5a-C5aR1 Axis Activation Drives Envenomation Immunopathology by the Snake Naja annulifera

open access: yesFrontiers in Immunology, 2021
Systemic complement activation drives a plethora of pathological conditions, but its role in snake envenoming remains obscure. Here, we explored complement’s contribution to the physiopathogenesis of Naja annulifera envenomation.
Felipe Silva de França   +6 more
doaj   +1 more source

Colubrid Venom Composition: An -Omics Perspective

open access: yesToxins, 2016
Snake venoms have been subjected to increasingly sensitive analyses for well over 100 years, but most research has been restricted to front-fanged snakes, which actually represent a relatively small proportion of extant species of advanced snakes ...
Inácio L. M. Junqueira-de-Azevedo   +3 more
doaj   +1 more source

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