Results 41 to 50 of about 112,374 (150)

P-I snake venom metalloproteinase is able to activate the complement system by direct cleavage of central components of the cascade. [PDF]

PLoS Neglected Tropical Diseases, 2013
BACKGROUND: Snake Venom Metalloproteinases (SVMPs) are amongst the key enzymes that contribute to the high toxicity of snake venom. We have recently shown that snake venoms from the Bothrops genus activate the Complement system (C) by promoting direct ...
Giselle Pidde-Queiroz, Fábio Carlos Magnoli, Fernanda C V Portaro, Solange M T Serrano, Aline Soriano Lopes, Adriana Franco Paes Leme, Carmen W van den Berg, Denise V Tambourgi   +7 more
doaj   +1 more source

Two-Dimensional Blue Native/SDS Polyacrylamide Gel Electrophoresis for Analysis of Brazilian Bothrops Snake Venoms

Toxins, 2022
Viperidae snakes are the most important agents of snakebites in Brazil. The protein composition of snake venoms has been frequently analyzed by means of electrophoretic techniques, but the interaction of proteins in venoms has barely been addressed.
Natacha Ferreira de Oliveira, Ana Teresa Azevedo Sachetto, Marcelo Larami Santoro   +2 more
doaj   +1 more source

Hemoperfusion as Adjunctive Therapy in Severe Snake Envenomation Refractory to Antivenom: A Case Series

Clinical Case Reports, Volume 14, Issue 9, September 2026.
ABSTRACT Snake envenomation remains a significant cause of morbidity worldwide, with antivenom serving as the cornerstone of treatment. This case series describes outcomes of three male patients (ages 34–63 years) with severe envenomation who demonstrated progressive local swelling and coagulopathy despite receiving at least 15 vials of antivenom.
Sayed Masoud Hosseini, Shahin Shadnia, Babak Mostafazadeh, Mitra Rahimi, Faraz Zandiyeh, Aida Rabiei Nezhad, Peyman Erfan Talab Evini   +6 more
wiley   +1 more source

Histopathological analysis and in situ localisation of Australian tiger snake venom in two clinically envenomed domestic animals [PDF]

, 2011
Objective: To assess histopathological changes in clinically envenomed tiger snake patients and identify tissue specific localisation of venom toxins using immunohistochemistry.
Jacoby-Alner, T.E., Davern, K.M., Swindells, K., Stephens, N., Balmer, L., Brown, S.G.A.   +5 more
core  

Is the South American water snake Helicops Angulatus (Linnaeus, 1758) (Ddipsadidae:Xenodontinae) venomous? [PDF]

, 2012
The dipsadid genus Helicops comprises sixteen species ocurring in all South American countries, with the exception of Chile. Such aquatic snakes inhabit rivers and lagoons of Tropical areas; all species have enlarged rear teeth, although a sulcus is ...
Rodríguez Torres, Alexandra, Serna, Lucía, Rodríguez Acosta, Alexis, Navarrete Sierra, Luis F., Estrella, Amalid   +4 more
core   +1 more source

Snake venomics of Bothrops punctatus, a semiarboreal pitviper species from Antioquia, Colombia [PDF]

PeerJ, 2014
Bothrops punctatus is an endangered, semi-arboreal pitviper species distributed in Panamá, Colombia, and Ecuador, whose venom is poorly characterized.
Maritza Fernández Culma, Jaime Andrés Pereañez, Vitelbina Núñez Rangel, Bruno Lomonte   +3 more
doaj   +2 more sources

Snake Venom Proteomics, Immunoreactivity and Toxicity Neutralization Studies for the Asiatic Mountain Pit Vipers, Ovophis convictus, Ovophis tonkinensis, and Hime Habu, Ovophis okinavensis

Toxins, 2021
Snakebite envenomation is a serious neglected tropical disease, and its management is often complicated by the diversity of snake venoms. In Asia, pit vipers of the Ovophis species complex are medically important venomous snakes whose venom properties ...
Choo Hock Tan, Praneetha Palasuberniam, Kae Yi Tan   +2 more
doaj   +1 more source

Immunological Cross‐Reactivity and Neutralizing Efficacy of Antivenom Against Five Medically Important Iranian Viper Venoms

Veterinary Medicine and Science, Volume 12, Issue 5, September 2026.
Investigating Iranian viper venoms reveals compositional and antigenic diversity impacting antivenom efficacy. The study highlights the need to incorporate both broadly cross‐reactive and specifically under‐represented venoms into immunization mixtures to optimize paraspecific protection strategies.
Sedigheh Khamehchian, Fatemeh Tahoori, Hadi Rabie, Nafiseh Nasri Nasrabadi, Majid Tebianian   +4 more
wiley   +1 more source

Differences in PLA₂ Constitution Distinguish the Venom of Two Endemic Brazilian Mountain Lanceheads, Bothrops cotiara and Bothrops fonsecai

Toxins, 2022
Interspecific differences in snake venom compositions can result from distinct regulatory mechanisms acting in each species. However, comparative analyses focusing on identifying regulatory elements and patterns that led to distinct venom composition are
Pedro G. Nachtigall, Luciana A. Freitas-de-Sousa, Andrew J. Mason, Ana M. Moura-da-Silva, Felipe G. Grazziotin, Inácio L. M. Junqueira-de-Azevedo   +5 more
doaj   +1 more source

The selective degradation of PDE4B shortform, using a PROTAC, leads to inhibition of several hallmarks of cancer in HCT116 cells

British Journal of Pharmacology, Volume 183, Issue 18, Page 5516-5540, September 2026.
Background and Purpose Colorectal cancer is one of the most prevalent cancers worldwide, and novel precision medicine approaches are rapidly improving patient outcomes. Phosphodiesterase 4B (PDE4B) is a member of an enzyme family (PDE4) that hydrolyses intracellular cAMP to control spatial and temporal signalling cues.
Alina Zorn, John Daniel Pediani, Madihah Hussain, Jiayue Ling, Elaine Brown, Igor Belka, Eduardo Torres, Cathy Swindlehurst, Kyle Chan, David Stirling, George S. Baillie, Yuan Yan Sin   +11 more
wiley   +1 more source