Results 51 to 60 of about 112,374 (150)

The genetics of venom ontogeny in the eastern diamondback rattlesnake (Crotalus adamanteus) [PDF]

PeerJ, 2017
The same selective forces that give rise to rapid inter- and intraspecific divergence in snake venoms can also favor differences in venoms across life-history stages.
Darin R. Rokyta, Mark J. Margres, Micaiah J. Ward, Elda E. Sanchez   +3 more
doaj   +2 more sources

Bioinformatics‐Driven Design and Evaluation of Recombinant Multi‐Epitope Immunogens Derived From Snake Venom Toxins as Potential Antivenom Candidates

Proteins: Structure, Function, and Bioinformatics, Volume 94, Issue 7, Page 1403-1426, July 2026.
ABSTRACT Snakebite envenomation is a major public health concern, particularly in low‐ and middle‐income regions where access to safe and effective antivenoms is limited. Traditional antivenoms, derived from immunization with crude venom, often trigger adverse reactions and lack specificity against key venom components.
Hanan Maoz, Amir Elalouf
wiley   +1 more source

Size Matters: An Evaluation of the Molecular Basis of Ontogenetic Modifications in the Composition of Bothrops jararacussu Snake Venom

Toxins, 2020
Ontogenetic changes in venom composition have been described in Bothrops snakes, but only a few studies have attempted to identify the targeted paralogues or the molecular mechanisms involved in modifications of gene expression during ontogeny.
Luciana A. Freitas-de-Sousa, Pedro G. Nachtigall, José A. Portes-Junior, Matthew L. Holding, Gunnar S. Nystrom, Schyler A. Ellsworth, Noranathan C. Guimarães, Emilly Tioyama, Flora Ortiz, Bruno R. Silva, Tobias S. Kunz, Inácio L. M. Junqueira-de-Azevedo, Felipe G. Grazziotin, Darin R. Rokyta, Ana M. Moura-da-Silva   +14 more
doaj   +1 more source

Degradomics for large‐scale mechanistic insights on proteases and proteolysis in human health

The FEBS Journal, Volume 293, Issue 13, Page 3881-3898, July 2026.
Proteolysis has an important role in human disease but remains relatively unexplored. Degradomics, the uncovering of proteolysis in tissues, cells, and proteins, uses mass spectrometry‐based terminomics to identify protein termini occurring therein (forward degradomics) and to define the actions of proteases (reverse degradomics).
Daniel R. Martin, Sumit Bhutada, Suneel S. Apte   +2 more
wiley   +1 more source

Unraveling the Processing and Activation of Snake Venom Metalloproteinases

, 2016
Snake venom metalloproteinases (SVMPs) are zinc-dependent enzymes responsible for most symptoms of human envenoming. Like matrix metalloproteinases (MMPs) and a disintegrin and metalloproteinase (ADAM) proteins, SVMPs are synthesized as zymogens, and ...
José A. Portes-Junior (1784578), Sylvia M. Carneiro (1784587), Gilberto B. Domont (1302003), Ana M. Moura-da-Silva (363584), Sávio S. Sant’Anna (1784581), Norma Yamanouye (363582), Paloma S. Knittel (1784572), Fabio C. S. Nogueira (1784584), Geraldo S. Magalhães (1784575), Magno Junqueira (246638)   +9 more
core   +1 more source

Inflammatory pathogenesis of snake venom metalloproteinase‐induced skin necrosis [PDF]

European Journal of Immunology, 2003
AbstractLocal tissue damage, characterized by edema, hemorrhage and necrosis, is a common consequence of envenoming by many vipers. We have investigated the contribution of inflammatory responses induced by the venom metalloproteinase jararhagin (isolated from Bothrops jararaca venom) in the development of these lesions.
Gavin David, Laing, Patricia Bianca, Clissa, Robert David Geoffrey, Theakston, Ana Maria, Moura-da-Silva, Mark John, Taylor   +4 more
openaire   +2 more sources

The Role of Endothelin‐1 in Autoimmune Diseases: Mechanistic Insights and Therapeutic Targets

iNew Medicine, Volume 2, Issue 2, June 2026.
The Role of Endothelin‐1 in Autoimmune Diseases. NF‐κB: nuclear factor kappa‐B; MAPK: mitogen‐activated protein kinase; PI3K: phosphoinositide 3‐kinase; ROS: reactive oxygen species; CTGF: connective tissue growth factor; TGF‐β: transforming growth factor‐β.
Xun Gong, Zhenyu Wang, Suyin Yang, Kaige Gao, Xin Yang, Min Tang   +5 more
wiley   +1 more source

Structure of carbohydrate chain of a thrombin-like protease from the venom of Agkistrodon halys brevicaudus stejneger snake [PDF]

, 2009
The structure of the carbohydrate chain of kangshuanmei, a thrombin-like serine protease isolated from Agkistrodon halys brevicaudus stejneger snake venom, was determined. The carbohydrate content of the kangshuanmei was 18%.
Saitou, Kenji, Okada, Tadashi, Sakai, Junichi, Murase, Yutaka, Jangprasert, Panchalee, Nakano, Takahiro, Yamamoto, Chikashi, Rojnuckarin, Ponlapat   +7 more
core   +1 more source

Molecular Docking Studies and Anti−Snake Venom Metalloproteinase Activity of Thai Mango Seed Kernel Extract

Molecules, 2009
Snakebite envenomations cause severe local tissue necrosis and the venom metalloproteinases are thought to be the key toxins involved. In this study, the ethanolic extract from seed kernels of Thai mango (Mangifera indica L. cv. ‘Fahlun’) (Anacardiaceae)
Pimolpan Pithayanukul, Jiraporn Leanpolchareanchai, Patchreenart Saparpakorn   +2 more
doaj   +1 more source

First structure of a snake venom metalloproteinase: a prototype for matrix metalloproteinases/collagenases. [PDF]

The EMBO Journal, 1993
Adamalysin II, a 24 kDa zinc endopeptidase from the snake venom of Crotalus adamanteus, is a member of a large family of metalloproteinases isolated as small proteinases or proteolytic domains of mosaic haemorrhagic proteins from various snake venoms. Homologous domains have recently been detected in multimodular mammalian reproductive tract proteins ...
F X, Gomis-Rüth, L F, Kress, W, Bode
openaire   +2 more sources