Results 61 to 70 of about 112,374 (150)

Potential targets for renal cell carcinoma therapy: Mechanistic research and prospects of CAFs in renal cell carcinoma

VIEW, Volume 7, Issue 3, June 2026.
Cancer‐associated fibroblasts exert intricate mechanisms in the progression and metastasis of renal cell carcinoma. Existing studies have validated the relevant mechanisms of three signaling pathways, which hold promising potential as novel therapeutic targets.
Ruiqiang Sun, Jiankun Zhang, Meixi Liu, Xiyue Dong, Yuanshan Cui   +4 more
wiley   +1 more source

Neurotoxins from Snake Venom [PDF]

, 1998
Found within snake venoms are a variety of toxic and nontoxic proteins. The effects of snake venoms depend on all of the components of that venom. However, the lethal effects are usually related to the most potent toxins found within the venom; the two ...
Tu, Anthony T.
core   +1 more source

The Role of Snake Venom Proteins in Inducing Inflammation Post-Envenomation: An Overview on Mechanistic Insights and Treatment Strategies

Toxins
The intricate combination of organic and inorganic compounds found in snake venom includes proteins, peptides, lipids, carbohydrates, nucleotides, and metal ions.
Sudharshan Rao, Nisha Reghu, Bipin Gopalakrishnan Nair, Muralidharan Vanuopadath   +3 more
doaj   +1 more source

Crystal structure and functional characterization of an Asp49 phospholipase A2 from the bushmaster (Lachesis muta)

Acta Crystallographica Section F, Volume 82, Issue 5, Page 150-159, May 2026.
The crystal structure of an Asp49 phospholipase A2 from L. muta is reported, revealing a tetrameric assembly, catalytic conservation and a polarized electrostatic surface potentially linked to membrane targeting.Snake‐venom phospholipases A2 (PLA2s) are small, structurally conserved enzymes that contribute significantly to the pathophysiology of ...
Noelia Erika Neyra Chama, Frey Francisco Romero Vargas, Eloy Condori Mamani, Jhon Antoni Vargas, Adriano Alves Furtado, Humberto D'Muniz Pereira, Ronald Demetrio Navarro Oviedo, Richard Charles Garratt, José Luis Javier Vega Ramírez, Diego Antonio Leonardo   +9 more
wiley   +1 more source

P-I metalloproteinases and L-amino acid oxidases from Bothrops species inhibit angiogenesis

Journal of Venomous Animals and Toxins including Tropical Diseases, 2021
Background: Snake venoms are composed of pharmacologically active proteins that are evolutionarily diverse, stable and specific to targets. Hence, venoms have been explored as a source of bioactive molecules in treating numerous diseases.
Shreesha K. Bhat, Manjunath B. Joshi, Sampara Vasishta, Rajesh N. Jagadale, Setlur G. Biligiri, Monika A. Coronado, Raghuvir K. Arni, Kapaettu Satyamoorthy   +7 more
doaj   +1 more source

Combination of Rhamnetin and RXP03 Mitigates Venom-Induced Toxicity in Murine Models: Preclinical Insights into Dual-Target Antivenom Therapy

Toxins
Snakebite is a significant global public health challenge, and the limited application of antivenom has driven the exploration of novel therapies. Combination therapy using small-molecule drugs targeting phospholipases A2 (PLA2) and metalloproteinases ...
Jianqi Zhao, Guangyao Liu, Xiao Shi, Chunhong Huang   +3 more
doaj   +1 more source

A transcriptomic view of the proteome variability of newborn and adult Bothrops jararaca snake venoms. [PDF]

PLoS Neglected Tropical Diseases, 2012
BACKGROUND: Snake bite is a neglected public health problem in communities in rural areas of several countries. Bothrops jararaca causes many snake bites in Brazil and previous studies have demonstrated that the pharmacological activities displayed by ...
André Zelanis, Débora Andrade-Silva, Marisa M Rocha, Maria F Furtado, Solange M T Serrano, Inácio L M Junqueira-de-Azevedo, Paulo Lee Ho   +6 more
doaj   +1 more source

Exploring Toxin Genes of Myanmar Russell’s Viper, Daboia siamensis, through De Novo Venom Gland Transcriptomics

Toxins, 2023
The Russell’s viper (Daboia siamensis) is a medically important venomous snake in Myanmar. Next-generation sequencing (NGS) shows potential to investigate the venom complexity, giving deeper insights into snakebite pathogenesis and possible drug ...
Khin Than Yee, Jason Macrander, Olga Vasieva, Ponlapat Rojnuckarin   +3 more
doaj   +1 more source

Estudo clínico-epidemiológico dos acidentes botrópicos atendidos no HU/UFSC em 2005 e 2006. [PDF]

, 2007
Trabalho de Conclusão de Curso - Universidade Federal de Santa Catarina. Curso de Medicina.
Rohr, Jaqueline Flores
core  

Analysis of the venom components of necrotic tissue exudates from Naja atra venom-infected Guangxi Bama miniature pigs

Guangxi Yike Daxue xuebao
Objective To investigate the components of snake venom and the dynamic changes in protein expression in the exudates of necrotic tissues affected by the Naja atra venom in Guangxi Bama miniature pigs.
XIAO Manqi, GUAN Zhezhe, HU Shaocong, LI Yalan, ZHANG Ziyan, JIANG Ningjing, ZHANG Xuerong, LIAO Ming   +7 more
doaj   +1 more source