Results 51 to 60 of about 34,979 (216)

Evaluating the Performance of De Novo Assembly Methods for Venom-Gland Transcriptomics

Toxins, 2018
Venom-gland transcriptomics is a key tool in the study of the evolution, ecology, function, and pharmacology of animal venoms. In particular, gene-expression variation and coding sequences gained through transcriptomics provide key information for ...
Matthew L. Holding, Mark J. Margres, Andrew J. Mason, Christopher L. Parkinson, Darin R. Rokyta   +4 more
doaj   +1 more source

Pictolysin-III, a Hemorrhagic Type-III Metalloproteinase Isolated from Bothrops pictus (Serpentes: Viperidae) Venom, Reduces Mitochondrial Respiration and Induces Cytokine Secretion in Epithelial and Stromal Cell Lines

Pharmaceutics, 2023
From the venom of the Bothrops pictus snake, an endemic species from Peru, we recently have described toxins that inhibited platelet aggregation and cancer cell migration.
Dan E. Vivas-Ruiz, Paola Rosas, Alex Proleón, Daniel Torrejón, Fanny Lazo, Ana Belén Tenorio-Ricca, Francisco Guajardo, Cristopher Almarza, Víctor Andrades, Jessica Astorga, Daniel Oropesa, Jorge Toledo, María Jesús Vera, Jorge Martínez, Ramiro Araya-Maturana, Karen Dubois-Camacho, Marcela A. Hermoso, Valéria G. Alvarenga, Eladio Flores Sanchez, Armando Yarlequé, Luciana Souza Oliveira, Félix A. Urra   +21 more
doaj   +1 more source

Role of accelerated segment switch in exons to alter targeting (ASSET) in the molecular evolution of snake venom proteins [PDF]

, 2009
BACKGROUND: Snake venom toxins evolve more rapidly than other proteins through accelerated changes in the protein coding regions. Previously we have shown that accelerated segment switch in exons to alter targeting (ASSET) might play an important role in
R Manjunatha Kini, Robin Doley, Stephen P Mackessy   +2 more
core   +3 more sources

Venom gland transcriptome analyses of two freshwater stingrays (Myliobatiformes : Potamotrygonidae) from Brazil [PDF]

, 2016
Stingrays commonly cause human envenoming related accidents in populations of the sea, near rivers and lakes. Transcriptomic profiles have been used to elucidate components of animal venom, since they are capable of providing molecular information on the
Alencar, Sérgio Amorim de, Cardoso, Marlon Henrique, Costa, Fabricio Falconi, Cândido, Elizabete de Souza, Fernandes, Gabriel da Rocha, Franco, Octávio Luiz, Garrone Neto, Domingos, Mortari, Márcia Renata, Oliveira Júnior, Nelson Gomes de, Schwartz, Elisabeth Nogueira Ferroni   +9 more
core   +2 more sources

Bioinformatics‐Driven Design and Evaluation of Recombinant Multi‐Epitope Immunogens Derived From Snake Venom Toxins as Potential Antivenom Candidates

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Snakebite envenomation is a major public health concern, particularly in low‐ and middle‐income regions where access to safe and effective antivenoms is limited. Traditional antivenoms, derived from immunization with crude venom, often trigger adverse reactions and lack specificity against key venom components.
Hanan Maoz, Amir Elalouf
wiley   +1 more source

Serum-based inhibition of pitviper venom by eastern indigo snakes (Drymarchon couperi)

Biology Open, 2019
When organisms possess chemical defenses, their predators may eventually evolve resistance to their toxins. Eastern indigo snakes (Drymarchon couperi; EIS) prey on pitvipers and are suspected to possess physiological resistance to their venom.
Scott M. Goetz, Sara Piccolomini, Michelle Hoffman, James Bogan, Matthew L. Holding, Mary T. Mendonça, David A. Steen   +6 more
doaj   +1 more source

Divergent Specialization of Simple Venom Gene Profiles among Rear-Fanged Snake Genera (Helicops and Leptodeira, Dipsadinae, Colubridae)

Toxins, 2022
Many venomous animals express toxins that show extraordinary levels of variation both within and among species. In snakes, most studies of venom variation focus on front-fanged species in the families Viperidae and Elapidae, even though rear-fanged ...
Peter A. Cerda, Jenna M. Crowe-Riddell, Deise J. P. Gonçalves, Drew A. Larson, Thomas F. Duda, Alison R. Davis Rabosky   +5 more
doaj   +1 more source

The urgent need to develop novel strategies for the diagnosis and treatment of snakebites [PDF]

, 2019
Snakebite envenoming (SBE) is a priority neglected tropical disease, which kills over one hundred thousand people per year. However, many millions of survivors also suffer through disabilities and long-term health consequences.
Aagaard-Hansen, Abbas, Bdolah, Bicknell, , Blaylock, Bouazza, Chippaux, CSL, Dhananjaya, Fry, Griffin, Harvey, Kalita, Kardong, Kardong, Kisiel, Kisiel, Layfield, , Litschka-Koen, Mackessy, Modahl, Omidfar, Ottesen, Patel, , Paul, Schetinger, Seth, Shah, Trim, , Vaiyapuri, Vaiyapuri, , Vallance, , Vijeth, Warrell, Warrell, Warrell, Wei, Williams, , Wüster, Zolfagharian   +39 more
core   +1 more source

Potential targets for renal cell carcinoma therapy: Mechanistic research and prospects of CAFs in renal cell carcinoma

VIEW, EarlyView.
Cancer‐associated fibroblasts exert intricate mechanisms in the progression and metastasis of renal cell carcinoma. Existing studies have validated the relevant mechanisms of three signaling pathways, which hold promising potential as novel therapeutic targets.
Ruiqiang Sun, Jiankun Zhang, Meixi Liu, Xiyue Dong, Yuanshan Cui   +4 more
wiley   +1 more source

Application of an Extracellular Matrix-Mimicking Fluorescent Polymer for the Detection of Proteolytic Venom Toxins

Toxins, 2023
The cytotoxicity caused by snake venoms is a serious medical problem that greatly contributes to the morbidity observed in snakebite patients. The cytotoxic components found in snake venoms belong to a variety of toxin classes and may cause cytotoxic ...
Eric Wachtel, Matyas A. Bittenbinder, Bas van de Velde, Julien Slagboom, Axel de Monts de Savasse, Luis L. Alonso, Nicholas R. Casewell, Freek J. Vonk, Jeroen Kool   +8 more
doaj   +1 more source