Results 201 to 210 of about 77,378 (253)

C-mannosylation promotes ADAMTS1 activation and secretion in human testicular germ cell tumor NEC8 cells. [PDF]

FEBS Lett
Kobayashi T, Suzuki T, Kawahara R, Harai N, Dohmae N, Simizu S.   +5 more
europepmc   +1 more source

The cytoplasmic domain of the pseudoprotease iRhom2 mediates distinct signaling mechanisms to control activation of the cell surface protease ADAM17. [PDF]

J Biol Chem
Lu F, Fournier M, Freeman M.
europepmc   +1 more source

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Disintegrins

Current Drug Target -Cardiovascular & Hematological Disorders, 2004
The existence of disintegrins, non-enzymatic, small molecular weight proteins from viper venom, has been known for 2 decades, and their impact on cellular research has been substantial and far-reaching. Disintegrins have been the molecular scaffold used in the design of therapeutics for the prevention of thrombosis and cancer.
Mary Ann, McLane, Elda E, Sanchez, Alice, Wong, Carrie, Paquette-Straub, John C, Perez   +4 more
openaire   +2 more sources

Disintegrins in health and disease

Frontiers in Bioscience, 2008
Few of the proteins isolated and characterized from snake venom have proven to be more chemically diverse, exquisitely specific or promiscuously active than the family known as disintegrins. These small proteins have shown structural homology with hundreds of cell surface molecules from plants and animals other than snakes, and their precise mimicry of
Mary Ann, McLane, Torsten, Joerger, Alaa, Mahmoud   +2 more
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Disintegrin and Metalloproteinases (ADAMs [A Disintegrin and Metalloproteinase] and ADAMTSs [ADAMs With a Thrombospondin Motif]) in Aortic Aneurysm

Hypertension, 2022
Aortic aneurysm is a complex pathology that can be lethal if not detected in time. Although several molecular mechanisms and pathways have been identified to be involved in aortic aneurysm development and growth, the current lack of an effective pharmacological treatment highlights the need for a more thorough understanding of the factors that regulate
Tolga Kilic, Keisuke Okuno, Satoru Eguchi, Zamaneh Kassiri   +3 more
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Anti-Angiogenesis and Disintegrins

2010
Angiogenesis is a critical process in tumor and disease progression. A number of features are central to both tumor growth and development, and the recruitment and invasion of a growing vascular network supplying the tumor with nutrients and a mechanism of escape to allow meastatic growth. One class of molecules important to both tumor growth and blood
Stephen Swenson, Radu Minea, Samuel Zidovetzki, Corey Helchowski, Fritz Costa, Francis S. Markland   +5 more
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Reduction of the Disintegrin and Metalloprotease ADAM12 in Preeclampsia

Obstetrics & Gynecology, 2005
The secreted form of ADAM12 is a metalloprotease that may be involved in placental and fetal growth. We examined whether the concentration of ADAM12 in first-trimester maternal serum could be used as a marker for preeclampsia.We developed a semiautomated, time-resolved, immunofluorometric assay for the quantification of ADAM12 in serum.
Laigaard, Jennie, Sørensen, Tina, Placing, Sophie, Holck, Peter, Frohlich, Camilla, Wøjdemann, Karen R, Sundberg, Karin, Shalmi, Anne-Cathrine, Tabor, Ann, Nørgaard-Pedersen, Bent, Ottesen, Bent, Christiansen, Michael, Wewer, Ulla M   +12 more
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A metalloprotease-disintegrin participating in myoblast fusion

Nature, 1995
Skeletal muscle development involves the formation of multi-nucleated myotubes. This is thought to proceed by the induction of differentiation (acquisition of fusion competence) of myoblast cells, their aggregation, and union of their plasma membranes.
T, Yagami-Hiromasa, T, Sato, T, Kurisaki, K, Kamijo, Y, Nabeshima, A, Fujisawa-Sehara   +5 more
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The Discovery of Disintegrins

2010
Disintegrins represent a class of low molecular weight, Arg-Gly-Asp(RGD)/Lys-Gly-Asp(KGD)-containing, cysteine-rich polypeptides derived from venoms of various viper snakes. They bind to various integrins (e.g. αIIbβ3, αvβ3, α5β1 and others) expressed on cell membrane surface, with various degrees of affinity and specificity.
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A New Gene Structure of the Disintegrin Family:  A Subunit of Dimeric Disintegrin Has a Short Coding Region

Biochemistry, 2002
Disintegrin is a potent platelet aggregation inhibitor isolated from various snake venoms. The cDNA of the snake venom disintegrin family precursor is well-known to encode pre-peptide, metalloprotease, spacer, and disintegrin domains. Recently, new types of disintegrins, dimeric disintegrins, have been isolated, and their amino acid sequences were ...
Daiju, Okuda, Hisashi, Koike, Takashi, Morita   +2 more
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