Results 211 to 220 of about 77,378 (253)
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The continuing saga of snake venom disintegrins
Toxicon, 2013Disintegrins, a family of polypeptides released in the venoms of viperid snakes (vipers and rattlesnakes) by the proteolytic processing of multidomain metalloproteinases, selectively block the function of β(1) and β(3) integrin receptors. Few of the proteins isolated and characterized from snake venoms have proven to be more structural and functional ...
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Toxicon, 2001
The homodimeric disintegrin contortrostatin was compared directly to the monomeric disintegrins echistatin and flavoridin for the ability to affect protein tyrosine phosphorylation in tumor cells. It was observed that contortrostatin had a dramatic effect on the tyrosine phosphorylation status of several proteins in T24 human bladder cancer cells ...
M R, Ritter, F S, Markland
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The homodimeric disintegrin contortrostatin was compared directly to the monomeric disintegrins echistatin and flavoridin for the ability to affect protein tyrosine phosphorylation in tumor cells. It was observed that contortrostatin had a dramatic effect on the tyrosine phosphorylation status of several proteins in T24 human bladder cancer cells ...
M R, Ritter, F S, Markland
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Inhibition of tumor formation by snake venom disintegrin
Toxicon, 2005The metastasis of tumor cells to bone involves migration, invasion and adhesion to bone. Breast and prostate cancer cells have predilection for spreading to bone. Snake venom-derived arginine-glycine-aspartic acid (RGD)-containing disintegrins (e.g. rhodostomin) have been demonstrated to inhibit cell adhesion.
Rong-Sen, Yang +6 more
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A team player: the disintegrin domain of ADAMTS13
Blood, 2009In this issue of Blood, de Groot and colleagues identify novel interactions between the disintegrin domain of ADAMTS13 and the A2 domain of VWF. This provides another piece in the puzzle of how this domain of ADAMTS13 works in concert with other domains to bind and process VWF.
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ADAMs, a disintegrin and metalloproteinases, mediate shedding of oxytocinase
Biochemical and Biophysical Research Communications, 2004Placental leucine aminopeptidase (P-LAP), a type-II transmembrane protease responsible for oxytocin degradation during pregnancy, is converted to a soluble form through proteolytic cleavage. The goal of this study was to determine the nature of the P-LAP secretase activity.
Norio, Ito +7 more
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Regulation of the proteolytic disintegrin metalloproteinases, the ‘Sheddases’
Seminars in Cell & Developmental Biology, 2009The proteolytically functional ADAMs, of which there are 13 in the human, play key roles in the way that many different types of cells respond to their environment. They act as 'signalling scissors' within various membrane environments, including at the cell surface, orchestrating rapid changes in the status of their transmembrane protein substrates ...
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New Insights into Disintegrin Metalloproteases
Inflammation Research, 1999T J, Carty +4 more
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Effect of type 2 diabetes on A disintegrin and metalloprotease 10
Journal of Diabetes, 2022Ying Wong, Kathryn C B Tan
exaly