Results 231 to 240 of about 78,401 (264)
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Current Drug Target -Cardiovascular & Hematological Disorders, 2004
The existence of disintegrins, non-enzymatic, small molecular weight proteins from viper venom, has been known for 2 decades, and their impact on cellular research has been substantial and far-reaching. Disintegrins have been the molecular scaffold used in the design of therapeutics for the prevention of thrombosis and cancer.
Mary Ann, McLane +4 more
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The existence of disintegrins, non-enzymatic, small molecular weight proteins from viper venom, has been known for 2 decades, and their impact on cellular research has been substantial and far-reaching. Disintegrins have been the molecular scaffold used in the design of therapeutics for the prevention of thrombosis and cancer.
Mary Ann, McLane +4 more
openaire +2 more sources
Disintegrins in health and disease
Frontiers in Bioscience, 2008Few of the proteins isolated and characterized from snake venom have proven to be more chemically diverse, exquisitely specific or promiscuously active than the family known as disintegrins. These small proteins have shown structural homology with hundreds of cell surface molecules from plants and animals other than snakes, and their precise mimicry of
Mary Ann, McLane +2 more
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Disintegrin Modulates Rat Glomerular Mesangial Cell Behavior
Nephron, 1995Disintegrins are a group of molecules containing Arg-Gly-Asp (RGD) sequence which can interfere with cell-matrix interaction. Rat mesangial cells are known to express an RGD-sensitive integrin receptor. We investigate the effect of a potent disintegrin, triflavin, on rat mesangial cell adhesion and proliferation. While synthetic RGD-containing peptide (
T J, Tsai +5 more
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Anti-Angiogenesis and Disintegrins
2010Angiogenesis is a critical process in tumor and disease progression. A number of features are central to both tumor growth and development, and the recruitment and invasion of a growing vascular network supplying the tumor with nutrients and a mechanism of escape to allow meastatic growth. One class of molecules important to both tumor growth and blood
Stephen Swenson +5 more
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A metalloprotease-disintegrin participating in myoblast fusion
Nature, 1995Skeletal muscle development involves the formation of multi-nucleated myotubes. This is thought to proceed by the induction of differentiation (acquisition of fusion competence) of myoblast cells, their aggregation, and union of their plasma membranes.
T, Yagami-Hiromasa +5 more
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Snake venom disintegrins: evolution of structure and function
Toxicon, 2005Disintegrins represent a family of polypeptides present in the venoms of various vipers that selectively block the function of integrin receptors. Here, we review our current view and hypothesis on the emergence and the structural and functional diversification of disintegrins by accelerated evolution and the selective loss of disulfide bonds of ...
Juan J, Calvete +6 more
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Inhibition of tumor formation by snake venom disintegrin
Toxicon, 2005The metastasis of tumor cells to bone involves migration, invasion and adhesion to bone. Breast and prostate cancer cells have predilection for spreading to bone. Snake venom-derived arginine-glycine-aspartic acid (RGD)-containing disintegrins (e.g. rhodostomin) have been demonstrated to inhibit cell adhesion.
Rong-Sen, Yang +6 more
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The continuing saga of snake venom disintegrins
Toxicon, 2013Disintegrins, a family of polypeptides released in the venoms of viperid snakes (vipers and rattlesnakes) by the proteolytic processing of multidomain metalloproteinases, selectively block the function of β(1) and β(3) integrin receptors. Few of the proteins isolated and characterized from snake venoms have proven to be more structural and functional ...
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Anti-Angiogenesis and RGD-Containing Snake Venom Disintegrins
Current Pharmaceutical Design, 2007Angiogenesis is the fundamental process by which new blood vessels are formed. Extensive research has shown that this event can be co-opted by tumors to ensure their growth, survival and metastasis. The study of tumor angiogenesis therefore represents a promising area of research for development of anti-cancer therapeutics.
Stephen, Swenson +2 more
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