Results 281 to 290 of about 51,218 (319)
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Current Drug Target -Cardiovascular & Hematological Disorders, 2004
The existence of disintegrins, non-enzymatic, small molecular weight proteins from viper venom, has been known for 2 decades, and their impact on cellular research has been substantial and far-reaching. Disintegrins have been the molecular scaffold used in the design of therapeutics for the prevention of thrombosis and cancer.
Mary Ann, McLane +4 more
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The existence of disintegrins, non-enzymatic, small molecular weight proteins from viper venom, has been known for 2 decades, and their impact on cellular research has been substantial and far-reaching. Disintegrins have been the molecular scaffold used in the design of therapeutics for the prevention of thrombosis and cancer.
Mary Ann, McLane +4 more
openaire +2 more sources
Disintegrins in health and disease
Frontiers in Bioscience, 2008Few of the proteins isolated and characterized from snake venom have proven to be more chemically diverse, exquisitely specific or promiscuously active than the family known as disintegrins. These small proteins have shown structural homology with hundreds of cell surface molecules from plants and animals other than snakes, and their precise mimicry of
Alaa Mahmoud +2 more
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Hypertension, 2022
Aortic aneurysm is a complex pathology that can be lethal if not detected in time. Although several molecular mechanisms and pathways have been identified to be involved in aortic aneurysm development and growth, the current lack of an effective pharmacological treatment highlights the need for a more thorough understanding of the factors that regulate
Tolga Kilic +3 more
openaire +2 more sources
Aortic aneurysm is a complex pathology that can be lethal if not detected in time. Although several molecular mechanisms and pathways have been identified to be involved in aortic aneurysm development and growth, the current lack of an effective pharmacological treatment highlights the need for a more thorough understanding of the factors that regulate
Tolga Kilic +3 more
openaire +2 more sources
Current Topics in Medicinal Chemistry, 2019
BACKGROUND Disintegrins from snake venoms bind with high specificity cell surface integrins, which are important pharmacological targets associated with cancer development and progression.
Leonel Montealegre-Sánchez +6 more
semanticscholar +1 more source
BACKGROUND Disintegrins from snake venoms bind with high specificity cell surface integrins, which are important pharmacological targets associated with cancer development and progression.
Leonel Montealegre-Sánchez +6 more
semanticscholar +1 more source
Reduction of the Disintegrin and Metalloprotease ADAM12 in Preeclampsia
Obstetrics & Gynecology, 2005The secreted form of ADAM12 is a metalloprotease that may be involved in placental and fetal growth. We examined whether the concentration of ADAM12 in first-trimester maternal serum could be used as a marker for preeclampsia.We developed a semiautomated, time-resolved, immunofluorometric assay for the quantification of ADAM12 in serum.
Laigaard, Jennie +12 more
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Anti-Angiogenesis and Disintegrins
2010Angiogenesis is a critical process in tumor and disease progression. A number of features are central to both tumor growth and development, and the recruitment and invasion of a growing vascular network supplying the tumor with nutrients and a mechanism of escape to allow meastatic growth. One class of molecules important to both tumor growth and blood
Fritz Costa +5 more
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A-Disintegrin-And-Metalloproteinase (ADAM) 10 Activity on Resting and Activated Platelets.
Biochemistry, 2016The primary platelet collagen receptor, glycoprotein VI (GPVI), plays an important role in platelet activation and thrombosis. The ectodomain of human GPVI (sGPVI) is proteolytically shed from human platelets by a-disintegrin-and-metalloproteinase 10 ...
A. Facey +8 more
semanticscholar +1 more source
A team player: the disintegrin domain of ADAMTS13 [PDF]
Blood, 2009 In this issue of Blood, de Groot and colleagues identify novel interactions between the disintegrin domain of ADAMTS13 and the A2 domain of VWF. This provides another piece in the puzzle of how this domain of ADAMTS13 works in concert with other domains to bind and process VWF.
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Biochemistry, 2002
Disintegrin is a potent platelet aggregation inhibitor isolated from various snake venoms. The cDNA of the snake venom disintegrin family precursor is well-known to encode pre-peptide, metalloprotease, spacer, and disintegrin domains. Recently, new types of disintegrins, dimeric disintegrins, have been isolated, and their amino acid sequences were ...
Hisashi Koike +2 more
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Disintegrin is a potent platelet aggregation inhibitor isolated from various snake venoms. The cDNA of the snake venom disintegrin family precursor is well-known to encode pre-peptide, metalloprotease, spacer, and disintegrin domains. Recently, new types of disintegrins, dimeric disintegrins, have been isolated, and their amino acid sequences were ...
Hisashi Koike +2 more
openaire +3 more sources
A metalloprotease-disintegrin participating in myoblast fusion
Nature, 1995Skeletal muscle development involves the formation of multi-nucleated myotubes. This is thought to proceed by the induction of differentiation (acquisition of fusion competence) of myoblast cells, their aggregation, and union of their plasma membranes.
Tomohiro Kurisaki +5 more
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