Results 101 to 110 of about 778,589 (272)

Micromorphological Investigations of Intervertebral Disk Degeneration using Electron Microscopy

Global Spine Journal, 2012
Introduction Intervertebral disk (ID) degeneration can be distinguished by various changes in the tissue structure like delamination and crack formation of the collagenous matrix as well as cellular changes like cell aging and variances in the amount and
A. Friedmann, S. Schwan, F. Goehre, A. Heilmann, H. J. Meisel   +4 more
doaj   +1 more source

Relaxor Ferroelectricity Enables Enhanced Thermoelectric Performance in In2Se3‐Alloyed GeTe

Advanced Science, EarlyView.
A non‐equimolar In3+/Se2− alloying strategy creates Ge vacancies in GeTe, inducing relaxor ferroelectricity that broadens the low thermal conductivity window. Simultaneously, cubic phase stabilization broadens optimal electrical transport, achieving an average zT > 1.0 over 330–625 K.
Yuting Zhang, Yang Li, Jianguo Chen, Kai Guo, Jun Luo, Jiye Zhang   +5 more
wiley   +1 more source

Different Origins of Intervertebral Disk Degeneration in the Upper and Lower Lumbar Spine

Global Spine Journal, 2012
Introduction The “weak link” in the thoracolumbar spine is the vertebral body endplate, which is easily damaged in compression. Vertebral endplate fracture can decompress the adjacent intervertebral disk and allow the annulus to collapse inwards.
M. A. Adams, P. Dolan
doaj   +1 more source

Large‐scale Whole‐Exome Sequencing Defines the Protein‐Coding Architecture of Retinal Structure, Visual Function, and Major Blinding Diseases

Advanced Science, EarlyView.
Large‐scale whole‐exome sequencing in 356,982 UK Biobank participants defines the protein‐coding architecture of retinal structure, visual function, and major blinding diseases. Pleiotropic genes, including CFI, C3, and RIOX1, bridge multiple retinal phenotypes, while experimental validation of FYB2 implicates RPE barrier dysfunction, providing ...
Jianqing Li, Yijun Ge, Jingxiao Du, Liu Yang, Bangsheng Wu, Chenyue Hang, Mengxi Shen, Yimin Mao, Ting Zhang, Qiyu Bo, Tianyuan Zhao, Yutian Jiao, Yazhi Wang, Shunxiang Gao, Jieqiong Chen, Junran Sun, Tong Li, Huixun Jia, Yang Dou, Wei Cheng, Xiaoling Wan, Jintai Yu, Xiaodong Sun, Bai Lu   +23 more
wiley   +1 more source

A Phosphorylation‐Induced Micellization Switch in the Low‐Complexity Domain of TDP‐43

Advanced Science, EarlyView.
Phosphorylation of TAR DNA‐binding protein's 43 kDa (TDP‐43) low‐complexity domain by casein kinase 1 delta (CK1δ) acts as a molecular switch, redirecting its self‐assembly from macroscopic phase separation toward finite‐sized, spherical block‐copolymer micelles of ∼30 nm.
Rodrigo F. Dillenburg, Anastasia Lopatina, Hao Ruan, Tom Scheidt, Simone Mosna, Emre Pekbilir, Julia Bieber, Frank Schäfer‐Depoix, Katharina Landfester, Carla Schmidt, Martin M. Möckel, Svenja Morsbach, Friederike Schmid, Dorothee Dormann, Lukas Stelzl, Martin Girard, Edward A. Lemke   +16 more
wiley   +1 more source

No Difference in Lumbar Disk Height between Operated and Nonoperated Patients at 9-Year Follow-Up

Global Spine Journal, 2012
Introduction Degeneration of the lumbar spine is a common and age-related finding in the normal population (1;2). Several factors may contribute to lumbar disk degeneration, such as ageing, genetic, and fusion (3).
A. Froholdt, J. I. Brox, G. Leivseth, O. Reikerås   +3 more
doaj   +1 more source

Engineered Brain‐Targeted Exosomes Delivering FGF1 for Sustained Glycemic Regulation and Multitarget Neurovascular Protection in Diabetic Stroke

Advanced Science, EarlyView.
ABSTRACT Diabetic stroke is characterized by a hyperglycemic and pro‐inflammatory microenvironment that exacerbates neurovascular dysfunction. However, the blood–brain barrier (BBB) remains a formidable obstacle, restricting the delivery of most therapeutic molecules.
Bixin Shen, Chengxiang Zhang, Junhui Wang, Xichong Zhong, Shihao Chen, Xue Wang, Xiaokun Li, Li Lin   +7 more
wiley   +1 more source

Does disk space degeneration according to Los Angeles and Modic scales have relation with recurrent disk herniation?

Advanced Biomedical Research, 2014
Background: After single disk herniation operation, about 5-20% recurrences may occur. Different etiology may affect the prevalence of recurrence. Disk degeneration according to Modic and Los Angles scales could affect recurrence rate.
Saied Abrishamkar, Mehdi Mahmoudkhani, Bahram Aminmansour, Amir Mahabadi, Shohreh Jafari   +4 more
doaj   +1 more source

A Decoy‐Receptor‐Armed Biomimetic Nanotherapeutic With Inherent Tropism for Conserved Pathogenic Macrophages for Treating Osteoarthritis and Intervertebral Disc Degeneration

Advanced Science, EarlyView.
A biomimetic doppelgänger nanosystem neutralizes extracellular inflammatory cytokines and silences intracellular pyroptosis, reprogramming pathogenic macrophages to attenuate both joint and spine degeneration. ABSTRACT Osteoarthritis (OA) and intervertebral disc degeneration (IVDD) are debilitating musculoskeletal disorders driven by shared ...
Fudong Li, Bin Zhang, Zhiqiu Zhang, Bing Zheng, Linhui Han, Chen Yan, Jialin Li, Kaiqiang Sun, Tianyi Zhao, Jiangang Shi   +9 more
wiley   +1 more source

Baseline MRI Characteristics in Asymptomatic Subjects as Predictors for Future First-Time LBP Episode

Global Spine Journal, 2012
Introduction Previously, it has been noted that there is no predictive value of MRI findings of degenerative changes of the lumbar spine in asymptomatic individuals in the development of first time episodes of low back pain (LBP).
D. Samartzis, J. Karppinen, K. Luk, K. Cheung   +3 more
doaj   +1 more source