Results 91 to 100 of about 778,589 (272)
Early Retinal UCHL1 Dysregulation Coupled With Synaptic Loss Reflects Alzheimer's Disease Severity
Advanced Science, EarlyView.This study identifies synapse‐enriched deubiquitinase UCHL1 as an early Aβ‐responsive regulator of retinal synaptopathy in Alzheimer's disease. Retinal UCHL1 loss accompanies excitatory synapse degeneration, p75NTR activation, and neuroinflammation, and predicts Braak stage and cognitive decline. Aβ42 fibrils trigger synaptic and UCHL1 depletion before
Altan Rentsendorj +25 more
wiley +1 more source
Mesenchymal Stem Cells Mediate Disk Regeneration by Suppression of Fibrosis in Nucleus Pulposus
Global Spine Journal, 2012 Introduction Confluent fibrosis, manifested as over-accumulation of fibrous matrix during tissue repair or remodeling, leads to scar formation and often organ failure.
V. Y. Leung +9 more
doaj +1 more source
Frontiers in Physiology, 2019 Obesity may promote intervertebral disc degeneration (IDD) by non-mechanical means, by influencing levels of free fatty acids which could impair cell metabolism.
Xuyang Zhang +9 more
semanticscholar +1 more source
Advanced Science, EarlyView.Local stress concentration disrupts metabolic homeostasis and induces inflammation in the nucleus pulposus (NP), thereby accelerating intervertebral disc degeneration (IDD). A biomimetic HA/ChS hydrogel millimeter sphere (ChS@HM) is developed to enable synergistic stress dispersion and sustained hydration lubrication.
Ang Li +4 more
wiley +1 more source
THBS1+ Macrophages Exacerbate Modic Changes via SDC4‐Dependent Activation of NLRP3 Inflammasome
Advanced Science, EarlyView.The illustration of THBS1+ macrophages exacerbate MCs via SDC4‐dependent activation of the NLRP3 inflammasome. THBS1+ macrophage subpopulation was identified in MCs through single‐cell RNA sequencing. C. acnes and its metabolites activate THBS1 expression in macrophages via the TLR signaling pathway.
Xiangxi Kong +16 more
wiley +1 more source
Diffusion Tensor Imaging for Quantitative Evaluation of Lumbar Intervertebral Disc Degeneration
Global Spine Journal, 2014 Introduction Pfirrmann classification, T2- and T1ρ mapping using MRI are tools to evaluate intervertebral disc (IVD) degeneration. Diffusion tensor imaging (DTI) and diffuion tensor tractography (DTT) are neuroimaging tools for visualizing highly ...
Y. Oikawa +13 more
doaj +1 more source
Advanced Science, EarlyView.Eligibility flow and real‐world AMD burden in the UKB retinal imaging cohort and TMUEH external‐validation cohort. Overview of the ORBIT‐AMD architecture, integrating retinal representation pretraining, bilateral eye‐graph modeling and concept bottleneck learning to support ordered risk, bilateral context, interpretable lesion concepts, longitudinal ...
Xuehao Cui +3 more
wiley +1 more source
Advances in Mechanical Engineering, 2015 Spinal interbody fusion is the most common surgery for treatment of disk degeneration, but the increased stress on adjacent level has been noted.
Jou-Wen Chen +4 more
doaj +1 more source
Cartilage Endplate and its Role in Disk Degeneration (Analytical Review of the Literature)
Bolʹ, Sustavy, Pozvonočnik, 2012 This review summarizes the current literature data on the structure and function of the cartilage endplate in humans and animals. Age aspect of the cartilage endplate changes and its disturbances in disk degeneration is presented.
L.M. Bengus, N.V. Dedukh
doaj +1 more source
Advanced Science, EarlyView.Electric field‑driven continuous gradient hydrogel GHZF4 achieves spatiotemporal growth factor release, modulates immune microenvironment, angiogenesis and osteochondral differentiation. It realizes cell‑free functional osteochondral repair in rat/rabbit models, offering a promising biomimetic strategy for gradient tissue regeneration.
Xiaolian Niu +7 more
wiley +1 more source