Results 71 to 80 of about 778,589 (272)

Retrograde Vertebral Bone Drilling-How does it Influence Vertebral Endplates and the Course of Disk Degeneration?

Global Spine Journal, 2012
Introduction Retrograde extra-articular bone drilling is a common procedure in orthopaedic surgery and offers good results in the therapy of osteochondral defects.
G. Omlor, F. Huettner, S. Lorenz, J. Holschbach, W. Richter, T. Gühring   +5 more
doaj   +1 more source

Sinapic Acid Inhibits IL-1β-Induced Apoptosis and Catabolism in Nucleus Pulposus Cells and Ameliorates Intervertebral Disk Degeneration

Journal of Inflammation Research, 2020
Background Low back pain (LBP) is a very common condition and leads to serious pain, disability, and price tag all over the world. Intervertebral disk degeneration (IDD) is one of the major reasons that contributed to LBP.
Jin-Feng Huang, Xuan-Qi Zheng, Jia-Liang Lin, Kai Zhang, Haijun Tian, Wen-xian Zhou, Hui Wang, Ze Gao, Hai-Ming Jin, Ai-Min Wu   +9 more
semanticscholar   +1 more source

Bioengineered Interfaces for Peripheral Nerve Sensory Restoration

Advanced Materials, EarlyView.
Half of amputees abandon their prosthetics for lack of feeling. This review charts the full path from peripheral nerve injury to restored sensation, through surgical, regenerative, noninvasive, and implanted approaches, and shows how injury type and interface material properties determine which strategy can deliver naturalistic feedback, and why ...
Sydney Swedick, Salim El Hadwe, Kesi Liang, George G. Malliaras, Damiano G. Barone   +4 more
wiley   +1 more source

Intervertebral Disk Degeneration is not a Direct Cause of Pain Behavior: An Experimental Study Using a Disk Puncture Model in Rats

Global Spine Journal, 2012
Introduction Low back pain (LBP) is a common symptom in patients with lumbar diseases. But the relationship between lumbar intervertebral disk degeneration and LBPis still a controversial issue. Some animal models were used to discuss this issue in prior
Z. Zheng, H. Liu, Z. Li, J. Wang, H. Yang, S. S. Sribastav   +5 more
doaj   +1 more source

Dental Microwear Texture Analysis on Radular Teeth

Advanced Materials Interfaces, EarlyView.
3D microwear textures reveal how gastropod radular teeth respond to controlled abrasive contact. Distinct surface signatures distinguish regular abrasion from fracture‐dominated material removal, showing how mineralized coatings, fibrous cores, and substrate properties jointly shape wear and failure in a biological scraping interface.
Wencke Krings, Stanislav N. Gorb, Ellen Schulz‐Kornas   +2 more
wiley   +1 more source

Phosphorylation‐Facilitated CKB Lactylation At K11 By GCN5 Enhances Creatine Kinase Activity and Mitigates Neuronal Damage After Cerebral Ischemia‐Reperfusion

Advanced Science, EarlyView.
This study uncovers hierarchical coordination between K11 lactylation and S199 phosphorylation of CKB in cerebral ischemia‐reperfusion injury. Such dual modifications potentiate CKB enzymatic function, remodel energy metabolism, alleviate oxidative stress and neuronal damage, and represent a viable therapeutic target for stroke treatment.
Chao Duan, Ruolin Zhang, Shihui Ding, Ying Feng, Tao Shen, Ziwei Wang, Wendai Bao, Ke Shui, Jun Qin, Jun Chen, Min Zhang, Zijing Ren, Dongmei Zhao, Xingrong Guo, Zhibing Ai, Xin Yang, Peiyang Zhou, Zhiqiang Dong   +17 more
wiley   +1 more source

miRNA-141 Induced Pyroptosis in Intervertebral Disk Degeneration by Targeting ROS Generation and Activating TXNIP/NLRP3 Signaling in Nucleus Pulpous Cells

Frontiers in Cell and Developmental Biology, 2020
The role and mechanism of pyroptosis in intervertebral disk (IVD) degeneration are unclear. MicroRNAs (miRNAs) regulate the viability and function of nucleus pulposus cells (NPCs) in IVDs and are related to pyroptosis. We performed microarray analyses of
Qiaolong Xu, Hong-Yuan Xing, Jiaqi Wu, Weishan Chen, Ning Zhang   +4 more
semanticscholar   +1 more source

Co‐Delivery of Sustained Release Chondroitinase ABC‐37 With Human iPSC‐Derived Neural Progenitors Promotes Transplant Survival and Functional Recovery in a Rodent Model of Stroke

Advanced Science, EarlyView.
A regenerative strategy for stroke combines human stem cell–derived neural progenitor cells with sustained release of a matrix‐modifying, thermostable chondroitinase ABC‐37 enzyme. In a rat model of stroke, co‐delivery enhanced transplanted cell survival and neuronal differentiation, degraded inhibitory extracellular matrix components, and improved ...
Nitzan Letko Khait, David Xinzheyang Li, Keyi Guo, Hong Cui, Quinton Sirianni, Dhana Abdo, Cindi M. Morshead, Molly S. Shoichet   +7 more
wiley   +1 more source

Orientation and Osteoarthritis of Lumbar Facet Joints: Association with Degenerative Disk Disease

Global Spine Journal, 2012
Introduction Several studies have shown relationship between sagittal orientation of lumbar facet joint and degenerative spondylolisthesis 1,2,3 ; however, there is no current information on how much the facet orientation and osteoarthritis associate ...
Y. Y. O. Lau, C. L. Y. Chan, K. O. Kwok, J. F. Griffith, S. W. Law, K. Y. Fung   +5 more
doaj   +1 more source

Silencing of Long Non-coding RNA NEAT1 Upregulates miR-195a to Attenuate Intervertebral Disk Degeneration via the BAX/BAK Pathway

Frontiers in Molecular Biosciences, 2020
Background/Aims An increasing body of evidence has demonstrated that long non-coding RNAs (lncRNAs) play a vital regulatory role in intervertebral disk degeneration (IVDD). Nucleus enriched abundant transcript 1 (NEAT1), a novel cancer-related lncRNA, is
Ning Tang, Yu-Lei Dong, Jia-Ming Liu, Hong Zhao   +3 more
semanticscholar   +1 more source