Results 61 to 70 of about 778,589 (272)

Advances and Prospects in Biomaterials for Intervertebral Disk Regeneration

Frontiers in Bioengineering and Biotechnology, 2021
Low-back and neck-shoulder pains caused by intervertebral disk degeneration are highly prevalent among middle-aged and elderly people globally. The main therapy method for intervertebral disk degeneration is surgical intervention, including interbody ...
Chunxu Li, Qiushi Bai, Yuxiao Lai, Jingjing Tian, Jiahao Li, Xiaodan Sun, Yu Zhao   +6 more
doaj   +1 more source

Cellular Responses to Mechanical Cues Across Scales: From Fundamental Insights to Translational Potential

Advanced Healthcare Materials, EarlyView.
This review examines how cellular behavior is regulated by mechanical cues transmitted through soft biomaterials, from single‐cell mechanosensing to tissue‐level adaptation. It highlights why physiological relevance, rather than model complexity alone, is critical for translational mechanobiology and introduces a scoring framework linking material ...
Mathias Polz, Manuel P. Kainz, Niklas Haider, Theresa Rienmüller, Kerstin Lenk, Rupert Kargl, Michele Terzano, Gerhard Sommer, Gerhard A. Holzapfel, Julia Fuchs   +9 more
wiley   +1 more source

Itaconate-loaded metal–organic framework (MOF) nanomedicine for the sustained treatment of intervertebral disk degeneration

APL Materials
Intervertebral disk degeneration (IVDD) is a major cause of spinal pathology and pain and can lead to disability in adults in severe cases. The medication against disk degeneration is limited due to the lack of therapeutic drugs and ineffective delivery ...
Haixin Song, Jianhua Li, Qibin Zhang, Bingjie Zheng, Changsheng Li, Yiran Wang, Jian Chen, Junhui Liu, Tao Wu, Xiaotian Yang, Xueqian Kong, Fengdong Zhao   +11 more
doaj   +1 more source

Photovoltaic Stimulation of Mouse and Pig Retina With Pyrolytic Carbon Microelectrodes Integrated on High‐Density Silicon Solar Cell Arrays

Advanced Healthcare Materials, EarlyView.
In this study, we fabricate photovoltaic retinal implants with pyrolytic carbon electrodes and test their ability to stimulate mouse and pig retinas when illuminated with near‐infrared light. We find increased spiking activity in both animal models compared to spontaneous activity and TTX controls and analyze the spike amplitude, latency and frequency.
Akihiro Matsumoto, Pratik Kusumanchi, Jesper Guldsmed Madsen, Asbjørn Cortnum Jørgensen, Gisele Alves dos Reis Benatto, Sune Thorsteinsson, Peter Behrensdorff Poulsen, Keisuke Yonehara, Toke Bek, Stephan Sylvest Keller, Rasmus Schmidt Davidsen   +10 more
wiley   +1 more source

Biomimetic Microstructural Materials for Intervertebral Disk Degeneration Repair

Small Structures
The intervertebral disks (IVD) serve as shock absorbers in the spine. As the largest avascular tissue in the human body, it has a limited capacity for regeneration.
Ang Li, Hui Yuan, Feng Cai, Juan Wang, Ze-Hao Chen, Xiaohu Li, Hongze Chang, Wenguo Cui, Xiaodong Liu   +8 more
semanticscholar   +1 more source

Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration

Advanced Healthcare Materials, EarlyView.
This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu, Lorenzo Moroni, Nicolas Lebonvallet, Vincent Flacher, Paul Wieringa   +4 more
wiley   +1 more source

Animal Models of Internal Endplate Injury-Induced Intervertebral Disc Degeneration: A Systematic Review

Journal of Investigative Surgery
Objective To systematically review relevant animal models of disk degeneration induced through the endplate injury pathway and to provide suitable animal models for exploring the intrinsic mechanisms and treatment of disk degeneration.Design PubMed, Web ...
Yukun Ma, Xing Yu, Wenhao Li, Jianbin Guan, Ziye Qiu, Luchun Xu, Ningning Feng, Guozheng Jiang, Xinliang Yue   +8 more
doaj   +1 more source

Is the Morphology and Size of Schmorl's Nodes of the Lumbar Spine Related to Severity of Disk Degeneration?

Global Spine Journal, 2012
Introduction We have recently confirmed that the presence of Schmorl's nodes (SN) was highly associated with disk degeneration in a large population-based cohort study in Southern Chinese.
D. Samartzis, F. Mok, J. Karppinen, K. Luk, K. Cheung   +4 more
doaj   +1 more source

Optical Detection of Cellular Signals at Material Interfaces

Advanced Healthcare Materials, EarlyView.
Emerging functional materials are transforming optical detection of cellular signals. This review highlights optical techniques that exploit the unique optical properties of diverse materials to detect and quantify cellular electrical, chemical, and mechanical signals, and discusses key opportunities and challenges.
Xuchen Ren, Jitong Ren, Zixin Zhang, Koney Eungkon Kim, Francis L. Hong, Yuecheng Peter Zhou   +5 more
wiley   +1 more source

Phase Engineering of Atomically Precise Nanoclusters (APNCs) of Gold and Beyond

Advanced Materials, EarlyView.
Engineering the structural phase of materials is of paramount importance for both fundamental research and practical applications. In this Review, we summarize the recent progress in controlling the phases of atomically precise nanoclusters (APNCs) of gold, silver and copper, as well as bimetallic systems. The phase‐enabled material properties of APNCs
Yitong Wang, Avirup Sardar, Weijie Ji, Zhongyu Liu, Rongchao Jin   +4 more
wiley   +1 more source