Results 201 to 210 of about 778,589 (272)
Acta Ophthalmologica, EarlyView.Abstract Purpose To estimate the real‐world incidence of intraocular inflammation (IOI) following intravitreal faricimab injections at a large, highly specialized tertiary centre. Methods Single‐centre, retrospective cohort study with chart review using an electronic injection database and electronic medical records from November 2023 to August 2024 ...
Miklos Schneider +7 more
wiley +1 more source
Clinical manifestations of dual‐gene variants in retinitis pigmentosa
Acta Ophthalmologica, EarlyView.Abstract Purpose Retinitis pigmentosa (RP) is an inherited retinal disease (IRD), whereby each affected individual typically harbours pathogenic variants in a single causative gene, yet the disorder exhibits marked genetic heterogeneity, with more than 100 genes reported to underlie RP.
Lasse Wolfram +11 more
wiley +1 more source
Retinal dystrophies simulating geographic atrophy: A diagnostic challenge
Acta Ophthalmologica, EarlyView.Abstract Geographic atrophy (GA) is the chronic loss of retinal pigment epithelium, photoreceptors and choriocapillaris, marking the dry late stage of age‐related macular degeneration (AMD). GA prevalence is expected to rise in the upcoming decades. Advanced GA leads to central scotomas, reducing visual acuity and quality of life, potentially resulting
Johanna M. Colijn +3 more
wiley +1 more source
Explainable deep learning self‐supervised vision transformer for fundus‐based myopia classification
Acta Ophthalmologica, EarlyView.Abstract Purpose To develop and validate a self‐supervised vision transformer (ViT) for automated three‐class classification of Normal, High Myopia (HM), and Pathologic Myopia (PM) from colour fundus photographs, with anatomically faithful interpretability. Methods A DINOv2 self‐supervised ViT was fine‐tuned using a two‐stage transfer‐learning protocol
Eirini Maliagkani +6 more
wiley +1 more source
Clinical and molecular features of PRCD‐associated retinopathy
Acta Ophthalmologica, EarlyView.Abstract Purpose To describe the clinical and genetic characteristics of patients with biallelic disease‐causing variants in the PRCD (Progressive Rod‐Cone Degeneration) gene. Methods Multicentre, retrospective cohort study of 19 patients from 13 families across nine reference centres in six countries.
Vasil Kostin +30 more
wiley +1 more source
British Journal of Haematology, EarlyView.Summary Young adults (YA) are particularly affected by comorbid conditions following allogeneic haematopoietic stem cell transplantation (alloHSCT), as they have to live with them for many years. This is the first multicentre prospective study investigating sequelae after alloHSCT in YA in Germany. In total, 107 patients who survived relapse‐free until
Pauline Rocke +9 more
wiley +1 more source
Artificial intelligence–based 3D segmentation of tangle‐associated TDP‐43 in neurodegeneration
Brain Pathology, EarlyView.Multiplex immunostaining of anti‐phosphorylated TDP‐43, tau (AT8, pS396, TauC3, MN423, GT38), and Thioflavin S combined with AI‐based object recognition, reconstruction, and TAT maturation analysis pipeline in limbic regions revealed that distinct aggregation and tangle maturation patterns underscored region‐specific dynamics in the neurodegenerative ...
Gokhan Uruk +6 more
wiley +1 more source
Novel approaches for drug development against chronic primary pain: A systematic review
British Journal of Pharmacology, EarlyView.Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source
Premium Intraocular Lens Selection in Patients With Glaucoma: A Clinical Review
Clinical &Experimental Ophthalmology, EarlyView.ABSTRACT Glaucoma frequently coexists with cataract, but glaucomatous functional loss, ocular‐surface disease, anatomical abnormalities, and treatment‐related refractive variability may reduce tolerance of premium intraocular lenses. This narrative review critically appraises evidence relevant to lens selection in glaucoma. Central visual‐field status,
Zhihao Liu +3 more
wiley +1 more source
Fast Injective Mesh Parameterization via Beltrami Coefficient Prolongation
Computer Graphics Forum, EarlyView.Abstract We present a highly efficient and robust method for free boundary injective parameterization of disk‐like triangle meshes with low isometric distortion. Harmonic function–based approaches, grounded in a strong mathematical framework, are widely employed.
G. Fargion, O. Weber
wiley +1 more source