Results 221 to 230 of about 778,589 (272)

Gene Therapy for Intervertebral Disk Degeneration

Orthopedic Clinics of North America, 2011
Intervertebral disk degeneration is a common and potentially debilitating disease process affecting millions of Americans and other populations each year. Current treatments address resultant symptoms and not the underlying pathophysiology of disease.
Nam Võ, Barrett Woods, Gwendolyn Sowa   +2 more
exaly   +3 more sources

Association Between Osteoarthritis Burden and Intervertebral Disk Degeneration in Patients Undergoing Lumbar Spine Surgery for Degenerative Lumbar Spondylolisthesis

Spine, 2023
Study Design. A retrospective analysis of prospectively collected data. Objective. To assess the association between intervertebral disk degeneration and hip and knee osteoarthritis (OA) in patients with degenerative lumbar spondylolisthesis. Background.
L. Schönnagel, G. Camino-Willhuber, S. Braun, Jia-Qi Zhu, Soji Tani, A. Guven, T. Caffard, E. Chiapparelli, A. Arzani, H. Haffer, Maximilian Muellner, J. Shue, R. Duculan, M. Bendersky, F. Cammisa, F. Girardi, A. Sama, C. Mancuso, A. Hughes   +18 more
semanticscholar   +1 more source

10-year Longitudinal MRI Study of Intervertebral Disk Degeneration in Patients With Lumbar Spinal Canal Stenosis After Posterior Lumbar Decompression Surgery

Spine, 2023
Study Design. A prospective longitudinal magnetic resonance imaging (MRI) study. Objective. The objective of this study was to describe the progression of intervertebral disk (IVD) degeneration in patients who underwent posterior decompression surgery ...
T. Fujii, Kenshi Daimon, Masahiro Ozaki, Satoshi Suzuki, Yohei Takahashi, Osahiko Tsuji, N. Nagoshi, M. Yagi, T. Michikawa, M. Matsumoto, M. Nakamura, Kota Watanabe   +11 more
semanticscholar   +1 more source

Lumbar disk compliance and degeneration

Surgical Neurology, 1989
Comparison between 242 intradiscal pressure/volume recordings and corresponding diskograms (performed at the same occasion) has shown a significant (p less than 0.01) correlation between disk compliance and the degree of diskographic degeneration. Intradiscal pressure/volume testing is a simple, reliable, and risk-free procedure that should precede ...
M, Brock, M, Lutze
openaire   +2 more sources

Update on the Correlation Between Mitochondrial Dysfunction and Intervertebral Disk Degeneration

DNA and Cell Biology, 2022
Low back pain (LBP) is a common disorder in orthopedic outpatients, affecting people of all ages, and some patients may develop chronic LBP. As a complex organelle, mitochondria are not only energy workstations but also regulate cell senescence ...
Cong Zhang, Xinjian Peng, Feng Wang, Zhiyang Xie, Lu Chen, Xiaotao Wu   +5 more
semanticscholar   +1 more source

Interleukin-1β in intervertebral disk degeneration

Clinica Chimica Acta, 2015
Intervertebral disk degeneration (IDD) is the most common diagnosis in patients with low back pain, a main cause of musculoskeletal disability in the world. Interleukin-1 (IL-1) β is the most important member of the IL-1 family, and has a strong pro-inflammatory activity by stimulating the secretion of multiple pro-inflammatory mediators.
Wei, Yang, Xiao-Hua, Yu, Cheng, Wang, Wen-Si, He, Shu-Jun, Zhang, Yi-Guo, Yan, Jian, Zhang, Yong-Xiao, Xiang, Wen-Jun, Wang   +8 more
openaire   +2 more sources

Bacteriology of Degenerated Lumbar Intervertebral Disks

Journal of Spinal Disorders & Techniques, 2012
A prospective microbiological analysis of intervertebral disk material in surgically treated patients presenting lumbar disk degeneration.To determine the prevalence and species of bacteria in degenerated lumbar disks, their eventual role in the pathophysiology, and the possible influence of risk factors.Intervertebral disk degeneration results from ...
Joseph, Arndt, Yann Philippe, Charles, Christelle, Koebel, Ioan, Bogorin, Jean-Paul, Steib   +4 more
openaire   +2 more sources

Lumbar Intervertebral Disk Degeneration in Athletes

The American Journal of Sports Medicine, 2008
Background Several studies have reported that physical loading related to competitive sports activities is associated with lumbar intervertebral disk degeneration. However, the association between types of sports activities and disk degeneration has not been clarified.
Mika, Hangai, Koji, Kaneoka, Shiro, Hinotsu, Ken, Shimizu, Yu, Okubo, Shumpei, Miyakawa, Naoki, Mukai, Masataka, Sakane, Naoyuki, Ochiai   +8 more
openaire   +2 more sources

Auto-immunological Basis of Disk Degeneration

Clinical Orthopaedics and Related Research, 1976
Ninety-four subjects were divided into 5 groups according to symptoms and radiologic findings to devise a test for immunoglobin levels and lymphocyte microstimulation. Cellular immunity to disk antigens can be demonstrated in disk degeneration which may be primary or secondary.
R S, Bisla, P J, Marchisello, M D, Lockshin, D M, Hart, R E, Marcus, J, Granda   +5 more
openaire   +2 more sources

Analysis of the role of PANoptosis in intervertebral disk degeneration via integrated bioinformatics analysis and experimental validation.

International Immunopharmacology
Intervertebral disc degeneration (IVDD) is an age-related orthopedic degenerative disease characterized by recurrent episodes of lower back pain, and death of nucleus pulposus cells (NPCs) has been identified as a key factor in the pathophysiological ...
Daqian Zhou, Jia-Le Lv, Yongliang Mei, Chao Song, Tao Liu, K. Cheng, Weiye Cai, Si-Ting Gao, Yang Zhou, Zhongwei Xiong, Zongchao Liu   +10 more
semanticscholar   +1 more source