Results 41 to 50 of about 386,467 (345)

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

Observation of the Impact of Dislocations on Atomic Polarization and Domain Structures in BaTiO3

Advanced Physics Research
Line defects, dislocations, in ferroelectric materials can facilitate the nucleation of new domains and pin the motion of domain walls, leading to significant electromechanical responses.
Shan Xiang, Yan Zhang, Miao Song, Edoardo Zatterin, Hanyu Gong, Fangping Zhuo, Kechao Zhou, Dou Zhang   +7 more
doaj   +1 more source

Molecular Dynamics Simulation of the Interaction between Dislocations and Iron–Vanadium Precipitates in Alpha Iron: Effect of Chemical Composition

Crystals, 2023
In this study, molecular dynamics simulations were employed to study the interaction between dislocations with Fe-V precipitate with different vanadium concentrations.
Sepehr Yazdani, Mohsen Mesbah, Veronique Vitry   +2 more
doaj   +1 more source

Carpal dislocations

Journal of Hand Surgery (European Volume), 2023
Carpal dislocations result from sequential disruption of the complex relationship between the bones and ligaments of the wrist. Injuries to the carpus occur via predictable mechanisms, an understanding of which is critical to identify and treat these frequently missed patterns of injury and to avoid the sequela of chronic instability.
Nathan, Heineman, Dang-Huy, Do, Ann, Golden   +2 more
openaire   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The 3D Stress Field of a Dislocation Line Outside a Cylindrical Void: A Numerical Collocation Point Method with Verification

Applied Sciences
Material defects resulting from manufacturing and processing can significantly affect material properties. Voids and dislocations are material defects considered in this study, in which a numerical solution of the 3D stress field of a dislocation line ...
Luo Li, Tariq Khraishi
doaj   +1 more source

Statistical aspects of microplasticity: experiments, discrete dislocation simulations and stochastic continuum models

Journal of the Mechanical Behavior of Materials, 2013
The plastic deformation properties of microscale and nanoscale specimens differ from those of their macroscopic counterparts as the discrete nature of the elementary processes governing plastic flow becomes directly visible. In such specimens, details of
Zaiser Michael
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

On the Evidence of Thermodynamic Self-Organization during Fatigue: A Review

Entropy, 2020
In this review paper, the evidence and application of thermodynamic self-organization are reviewed for metals typically with single crystals subjected to cyclic loading. The theory of self-organization in thermodynamic processes far from equilibrium is a
Mehdi Naderi
doaj   +1 more source