Results 41 to 50 of about 51,708 (269)

Multiple Valence Bands Convergence and Localized Lattice Engineering Lead to Superhigh Thermoelectric Figure of Merit in MnTe

Advanced Science, 2023
MnTe has been considered a promising candidate for lead‐free mid‐temperature range thermoelectric clean energy conversions. However, the widespread use of this technology is constrained by the relatively low‐cost performance of materials.
Shahzada Zulkifal, Zhichao Wang, Xuemei Zhang, Suniya Siddique, Yuan Yu, Chong Wang, Yaru Gong, Shuang Li, Di Li, Yongsheng Zhang, Peng Wang, Guodong Tang   +11 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Acoustic emission and the Portevin-Le Châtelier effect in tensile tested Al alloys processed by ARB technique

Archives of Acoustics, 2014
The paper presents the investigations of the relation between the acoustic emission (AE) and the Portevin-Le Châtelier (PL) phenomena occurring in tensile tested two kinds of aluminium alloys: not-predeformed and predeformed earlier using the technique ...
Andrzej PAWEŁEK, Jan KUŚNIERZ, Joanna BOGUCKA, Zdzisław JASIEŃSKI, Zbigniew RANACHOWSKI, Przemysław RANACHOWSKI, Feliks REJMUND, Tomasz DĘBOWSKI   +7 more
doaj  

Thermoelectric Enhancements in PbTe Alloys Due to Dislocation‐Induced Strains and Converged Bands

Advanced Science, 2020
In‐grain dislocation‐induced lattice strain fluctuations are recently revealed as an effective avenue for minimizing the lattice thermal conductivity. This effect could be integratable with electronic enhancements such as by band convergence, for a great
Yixuan Wu, Pengfei Nan, Zhiwei Chen, Zezhu Zeng, Ruiheng Liu, Hongliang Dong, Li Xie, Youwei Xiao, Zhiqiang Chen, Hongkai Gu, Wen Li, Yue Chen, Binghui Ge, Yanzhong Pei   +13 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

PLASTIC DEFORMATION EVOLUTION AT BLUNT CRACK TIP IN CRYSTAL

Advanced Engineering Research, 2011
The plastic deformation evolution at the crack tip in ?-Fe crystal under the condition of the plane deformation (modes I, II) is calculated. Temporal distributions for the plastic deformation, effective shear stress, stress intensity factor are derived ...
Dmitry N. Karpinskiy, Sergey V. Sannikov, Boris V. Sobol   +2 more
doaj  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source